DegronMD

Uniprot ID: Q9H4Q3

Source protein: PR domain zinc finger protein 13

Source gene: PRDM13

Class: LIG_APCC_ABBA_1

Location: 607:612

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7685

ASA_SCORE: 74.25

COIL: 0.8077

CONS_SCORE: 0.72

DSS_SCORE: 0.1538

HELIX: 0.0052

FCONS_SCORE: 0.9765

RIG_SCORE: 0.7768

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L607M	TCGA-06-5416	GBM	TCGA	LRPFGD	LIG_APCC_ABBA_1	0.5999
p.L607M	DO10880	GBM	ICGC	LRPFGD	LIG_APCC_ABBA_1	0.5999
p.F610L	TCGA-60-2698	LUSC	TCGA	LRPFGD	LIG_APCC_ABBA_1	0.6981
p.F610L	DO228460	BRCA	ICGC	LRPFGD	LIG_APCC_ABBA_1	0.6981
p.F610L	DO26469	LUSC	ICGC	LRPFGD	LIG_APCC_ABBA_1	0.6981
p.K599T	TCGA-AJ-A5DW	UCEC	TCGA	LRPFGD	LIG_APCC_ABBA_1	0.2222
p.K599T	DO50075	UCEC	ICGC	LRPFGD	LIG_APCC_ABBA_1	0.2222
p.D612G	TCGA-CG-5721	STAD	TCGA	LRPFGD	LIG_APCC_ABBA_1	0.7198
p.D612G	DO38192	STAD	ICGC	LRPFGD	LIG_APCC_ABBA_1	0.7198
p.D612N	DO234378	ESAD	ICGC	LRPFGD	LIG_APCC_ABBA_1	0.6932
p.L616P	DO234457	ESAD	ICGC	LRPFGD	LIG_APCC_ABBA_1	0.2222
p.R621W	DO233867	GACA	ICGC	LRPFGD	LIG_APCC_ABBA_1	0.0833
p.D612Y	DO228976	LICA	ICGC	LRPFGD	LIG_APCC_ABBA_1	0.7325
p.C606F	DO229034	LICA	ICGC	LRPFGD	LIG_APCC_ABBA_1	0.3056
p.P600L	SIDM01148	Plasma Cell Myeloma	GDSC	LRPFGD	LIG_APCC_ABBA_1	0.1389
p.P600L	ACH-000050	Myeloma	CCLE	LRPFGD	LIG_APCC_ABBA_1	0.1389
p.P600L	NCI-H929	haematopoietic_and_lymphoid_tissue	COSMIC	LRPFGD	LIG_APCC_ABBA_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H4Q3	PR domain zinc finger protein 13	LIG_APCC_ABBA_1	607:612	LRPFGD	APC,CDC20,FZR1	0.7685	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons