DegronMD

Uniprot ID: Q9C0E4

Source protein: Glutamate receptor-interacting protein 2

Source gene: GRIP2

Class: DEG_APCC_DBOX_1

Location: 497:505

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6291

ASA_SCORE: 65.1778

COIL: 0.7004

CONS_SCORE: 0.6317

DSS_SCORE: 0.2662

HELIX: 0.2478

FCONS_SCORE: 1.0862

RIG_SCORE: 0.8099

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I511V	SIDM01154	T-Lymphoblastic Leukemia	GDSC	ERCGLLQVG	DEG_APCC_DBOX_1	0.1667
p.I511V	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	ERCGLLQVG	DEG_APCC_DBOX_1	0.1667
p.V508A	SIDM00878	Breast Carcinoma	GDSC	ERCGLLQVG	DEG_APCC_DBOX_1	0.25
p.V508A	HCC1569	breast	COSMIC	ERCGLLQVG	DEG_APCC_DBOX_1	0.25
p.G505R	SIDM00150	Colorectal Carcinoma	GDSC	ERCGLLQVG	DEG_APCC_DBOX_1	0.6457
p.G505R	KM12	large_intestine	COSMIC	ERCGLLQVG	DEG_APCC_DBOX_1	0.6457
p.S491L	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	ERCGLLQVG	DEG_APCC_DBOX_1	0.1667
p.P488L	SW1271	lung	COSMIC	ERCGLLQVG	DEG_APCC_DBOX_1	0.0833
p.G510R	KM12	large_intestine	COSMIC	ERCGLLQVG	DEG_APCC_DBOX_1	0.1944
p.V513A	HCC1569	breast	COSMIC	ERCGLLQVG	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0E4	Glutamate receptor-interacting protein 2	DEG_APCC_DBOX_1	497:505	ERCGLLQVG	APC,CDC20,FZR1	0.6291	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons