DegronMD - Q9C0E4(GRIP2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I397V	SIDM02039	Colorectal Carcinoma	GDSC	LSSTPFSS	DEG_SCF_FBW7_1	387:394	Mutation rewiring degron network	0.25
p.P391L	SIDM01156	Small Cell Lung Carcinoma	GDSC	LSSTPFSS	DEG_SCF_FBW7_1	387:394	Mutation altering degron motif	0.7582
p.P391L	SW1271	lung	COSMIC	LSSTPFSS	DEG_SCF_FBW7_1	387:394	Mutation altering degron motif	0.7582
p.I511V	SIDM01154	T-Lymphoblastic Leukemia	GDSC	ERCGLLQVG	DEG_APCC_DBOX_1	497:505	Mutation rewiring degron network	0.1667
p.I511V	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	ERCGLLQVG	DEG_APCC_DBOX_1	497:505	Mutation rewiring degron network	0.1667
p.V508A	SIDM00878	Breast Carcinoma	GDSC	ERCGLLQVG	DEG_APCC_DBOX_1	497:505	Mutation rewiring degron network	0.25
p.V508A	HCC1569	breast	COSMIC	ERCGLLQVG	DEG_APCC_DBOX_1	497:505	Mutation rewiring degron network	0.25
p.S394L	SIDM00429	B-Lymphoblastic Leukemia	GDSC	LSSTPFSS	DEG_SCF_FBW7_1	387:394	Mutation altering degron motif	0.7667
p.S394L	NALM-6	haematopoietic and lymphoid tissue	COSMIC	LSSTPFSS	DEG_SCF_FBW7_1	387:394	Mutation altering degron motif	0.7667
p.G505R	SIDM00150	Colorectal Carcinoma	GDSC	ERCGLLQVG	DEG_APCC_DBOX_1	497:505	Mutation altering degron motif	0.6457
p.G505R	KM12	large intestine	COSMIC	ERCGLLQVG	DEG_APCC_DBOX_1	497:505	Mutation altering degron motif	0.6457
p.V381M	RPMI-8226	haematopoietic and lymphoid tissue	COSMIC	LSSTPFSS	DEG_SCF_FBW7_1	387:394	Mutation rewiring degron network	0.1667
p.S491L	NALM-6	haematopoietic and lymphoid tissue	COSMIC	ERCGLLQVG	DEG_APCC_DBOX_1	497:505	Mutation rewiring degron network	0.1667
p.P488L	SW1271	lung	COSMIC	ERCGLLQVG	DEG_APCC_DBOX_1	497:505	Mutation rewiring degron network	0.0833
p.G510R	KM12	large intestine	COSMIC	ERCGLLQVG	DEG_APCC_DBOX_1	497:505	Mutation rewiring degron network	0.1944
p.S399L	NALM-6	haematopoietic and lymphoid tissue	COSMIC	LSSTPFSS	DEG_SCF_FBW7_1	387:394	Mutation rewiring degron network	0.1944
p.V513A	HCC1569	breast	COSMIC	ERCGLLQVG	DEG_APCC_DBOX_1	497:505	Mutation rewiring degron network	0.1111
p.K832T	YT	haematopoietic and lymphoid tissue	COSMIC	PTPADE	DEG_SCF_FBW7_2	837:842	Mutation rewiring degron network	0.1944
p.P396L	SW1271	lung	COSMIC	LSSTPFSS	DEG_SCF_FBW7_1	387:394	Mutation rewiring degron network	0.2778

Kaplan plot for GRIP2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GRIP2

UniProt ID: Q9C0E4

Entrez ID: 80852

Protein name: Glutamate receptor-interacting protein 2 (GRIP-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GRIP2 in