DegronMD

Uniprot ID: Q9C0E4

Source protein: Glutamate receptor-interacting protein 2

Source gene: GRIP2

Class: DEG_SCF_FBW7_1

Location: 387:394

E3 ligase: FBXW7

DEGRON score: 0.978

ASA_SCORE: 74.1375

COIL: 0.9173

CONS_SCORE: 0.2773

DSS_SCORE: 0.622

HELIX: 0.0284

FCONS_SCORE: 1.0034

RIG_SCORE: 0.5985

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I397V	SIDM02039	Colorectal Carcinoma	GDSC	LSSTPFSS	DEG_SCF_FBW7_1	0.25
p.P391L	SIDM01156	Small Cell Lung Carcinoma	GDSC	LSSTPFSS	DEG_SCF_FBW7_1	0.7582
p.P391L	SW1271	lung	COSMIC	LSSTPFSS	DEG_SCF_FBW7_1	0.7582
p.S394L	SIDM00429	B-Lymphoblastic Leukemia	GDSC	LSSTPFSS	DEG_SCF_FBW7_1	0.7667
p.S394L	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	LSSTPFSS	DEG_SCF_FBW7_1	0.7667
p.V381M	RPMI-8226	haematopoietic_and_lymphoid_tissue	COSMIC	LSSTPFSS	DEG_SCF_FBW7_1	0.1667
p.S399L	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	LSSTPFSS	DEG_SCF_FBW7_1	0.1944
p.P396L	SW1271	lung	COSMIC	LSSTPFSS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0E4	Glutamate receptor-interacting protein 2	DEG_SCF_FBW7_1	387:394	LSSTPFSS	FBXW7	0.978	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons