DegronMD

Uniprot ID: Q8N1F8

Source protein: Serine/threonine-protein kinase 11-interacting protein

Source gene: STK11IP

Class: DEG_APCC_DBOX_1

Location: 781:789

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8788

ASA_SCORE: 60.9222

COIL: 0.671

CONS_SCORE: 0.3287

DSS_SCORE: 0.3122

HELIX: 0.2003

FCONS_SCORE: 0.9808

RIG_SCORE: 0.7112

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T779S	TCGA-78-7155	LUAD	TCGA	ERCGLRSVD	DEG_APCC_DBOX_1	0.2778
p.T779S	DO23590	LUAD	ICGC	ERCGLRSVD	DEG_APCC_DBOX_1	0.2778
p.P777L	TCGA-D9-A6EC	SKCM	TCGA	ERCGLRSVD	DEG_APCC_DBOX_1	0.6667
p.P777L	DO50291	SKCM	ICGC	ERCGLRSVD	DEG_APCC_DBOX_1	0.6667
p.Q775E	TCGA-FD-A6TC	BLCA	TCGA	ERCGLRSVD	DEG_APCC_DBOX_1	0.6111
p.Q775E	DO49755	BLCA	ICGC	ERCGLRSVD	DEG_APCC_DBOX_1	0.6111
p.N771K	DO228819	LICA	ICGC	ERCGLRSVD	DEG_APCC_DBOX_1	0.0556
p.D781Y	DO229038	LICA	ICGC	ERCGLRSVD	DEG_APCC_DBOX_1	0.7325
p.S777R	SIDM01179	Other Sarcomas	GDSC	ERCGLRSVD	DEG_APCC_DBOX_1	0.6667
p.S777R	ACH-001702	Sarcoma	CCLE	ERCGLRSVD	DEG_APCC_DBOX_1	0.6667
p.S777R	VA-ES-BJ	bone	COSMIC	ERCGLRSVD	DEG_APCC_DBOX_1	0.6667
p.P779S	SIDM00188	Kidney Carcinoma	GDSC	ERCGLRSVD	DEG_APCC_DBOX_1	0.2778
p.P779S	SIDM01218	Other Solid Cancers	GDSC	ERCGLRSVD	DEG_APCC_DBOX_1	0.2778
p.P779S	SIDM01711	Non-Cancerous	GDSC	ERCGLRSVD	DEG_APCC_DBOX_1	0.2778
p.L792V	SIDM01322	Oral Cavity Carcinoma	GDSC	ERCGLRSVD	DEG_APCC_DBOX_1	0.25
p.L792V	ACH-000735	Head and Neck Cancer	CCLE	ERCGLRSVD	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N1F8	Serine/threonine-protein kinase 11-interacting protein	DEG_APCC_DBOX_1	781:789	ERCGLRSVD	APC,CDC20,FZR1	0.8788	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons