DegronMD - Q8N1F8(STK11IP)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T779S	TCGA-78-7155	LUAD	TCGA	ERCGLRSVD	DEG_APCC_DBOX_1	781:789	Mutation rewiring degron network	0.2778
p.T779S	DO23590	LUAD	ICGC	ERCGLRSVD	DEG_APCC_DBOX_1	781:789	Mutation rewiring degron network	0.2778
p.E810V	TCGA-D8-A1X7	BRCA	TCGA	VEVFSD	LIG_APCC_ABBA_1	798:803	Mutation rewiring degron network	0.1389
p.E810V	DO1303	BRCA	ICGC	VEVFSD	LIG_APCC_ABBA_1	798:803	Mutation rewiring degron network	0.1389
p.P777L	TCGA-D9-A6EC	SKCM	TCGA	ERCGLRSVD	DEG_APCC_DBOX_1	781:789	Mutation blocking phosphorylation signal	0.6667
p.P777L	DO50291	SKCM	ICGC	ERCGLRSVD	DEG_APCC_DBOX_1	781:789	Mutation blocking phosphorylation signal	0.6667
p.R434L	TCGA-DA-A1I1	SKCM	TCGA	LPATPTTS	DEG_SCF_FBW7_1	444:451	Mutation rewiring degron network	0.0556
p.R434L	DO37966	SKCM	ICGC	LPATPTTS	DEG_SCF_FBW7_1	444:451	Mutation rewiring degron network	0.0556
p.G351D	TCGA-DD-AADL	LIHC	TCGA	VGSTPETS	DEG_SCF_FBW7_1	347:354	Mutation altering degron motif	0.7198
p.G351D	DO52237	LIHC	ICGC	VGSTPETS	DEG_SCF_FBW7_1	347:354	Mutation altering degron motif	0.7198
p.Q775E	TCGA-FD-A6TC	BLCA	TCGA	ERCGLRSVD	DEG_APCC_DBOX_1	781:789	Mutation blocking phosphorylation signal	0.6111
p.Q775E	DO49755	BLCA	ICGC	ERCGLRSVD	DEG_APCC_DBOX_1	781:789	Mutation blocking phosphorylation signal	0.6111
p.M350L	TCGA-MP-A4T7	LUAD	TCGA	VGSTPETS	DEG_SCF_FBW7_1	347:354	Mutation altering degron motif	0.711
p.M350L	DO45370	LUAD	ICGC	VGSTPETS	DEG_SCF_FBW7_1	347:354	Mutation altering degron motif	0.711
p.L455R	TCGA-ZF-AA56	BLCA	TCGA	LPATPTTS	DEG_SCF_FBW7_1	444:451	Mutation rewiring degron network	0.2222
p.L455R	DO219099	BLCA	ICGC	LPATPTTS	DEG_SCF_FBW7_1	444:451	Mutation rewiring degron network	0.2222
p.D338V	DO230311	COCA	ICGC	VGSTPETS	DEG_SCF_FBW7_1	347:354	Mutation rewiring degron network	0.0833
p.R804Q	DO48232	ESCA	ICGC	VEVFSD	LIG_APCC_ABBA_1	798:803	Mutation rewiring degron network	0.3056
p.N771K	DO228819	LICA	ICGC	ERCGLRSVD	DEG_APCC_DBOX_1	781:789	Mutation rewiring degron network	0.0556
p.D781Y	DO229038	LICA	ICGC	ERCGLRSVD	DEG_APCC_DBOX_1	781:789	Mutation altering degron motif	0.7325
p.R439C	DO231075	LUSC	ICGC	LPATPTTS	DEG_SCF_FBW7_1	444:451	Mutation rewiring degron network	0.1944
p.R434W	DO222363	MELA	ICGC	LPATPTTS	DEG_SCF_FBW7_1	444:451	Mutation rewiring degron network	0.0556
p.R434W	DO222494	MELA	ICGC	LPATPTTS	DEG_SCF_FBW7_1	444:451	Mutation rewiring degron network	0.0556
p.S348N	DO232224	PBCA	ICGC	VGSTPETS	DEG_SCF_FBW7_1	347:354	Mutation altering degron motif	0.7069
p.G438S	DO232224	PBCA	ICGC	LPATPTTS	DEG_SCF_FBW7_1	444:451	Mutation rewiring degron network	0.1667
p.S802R	SIDM00330	Neuroblastoma	GDSC	VEVFSD	LIG_APCC_ABBA_1	798:803	Mutation altering degron motif	0.6316
p.S802R	SIDM00352	Ovarian Carcinoma	GDSC	VEVFSD	LIG_APCC_ABBA_1	798:803	Mutation altering degron motif	0.6316
p.S802R	SIDM00296	Small Cell Lung Carcinoma	GDSC	VEVFSD	LIG_APCC_ABBA_1	798:803	Mutation altering degron motif	0.6316
p.S802R	SIDM01093	Cervical Carcinoma	GDSC	VEVFSD	LIG_APCC_ABBA_1	798:803	Mutation altering degron motif	0.6316
p.S802R	SIDM01247	Burkitt's Lymphoma	GDSC	VEVFSD	LIG_APCC_ABBA_1	798:803	Mutation altering degron motif	0.6316
p.S802R	SIDM01680	Non-Cancerous	GDSC	VEVFSD	LIG_APCC_ABBA_1	798:803	Mutation altering degron motif	0.6316
p.S802R	SIDM00576	Acute Myeloid Leukemia	GDSC	VEVFSD	LIG_APCC_ABBA_1	798:803	Mutation altering degron motif	0.6316
p.S802R	SIDM00397	Acute Myeloid Leukemia	GDSC	VEVFSD	LIG_APCC_ABBA_1	798:803	Mutation altering degron motif	0.6316
p.S802R	SIDM00850	Gastric Carcinoma	GDSC	VEVFSD	LIG_APCC_ABBA_1	798:803	Mutation altering degron motif	0.6316
p.S802R	SIDM01447	Glioblastoma	GDSC	VEVFSD	LIG_APCC_ABBA_1	798:803	Mutation altering degron motif	0.6316
p.S777R	SIDM01179	Other Sarcomas	GDSC	ERCGLRSVD	DEG_APCC_DBOX_1	781:789	Mutation blocking phosphorylation signal	0.6667
p.S777R	ACH-001702	Sarcoma	CCLE	ERCGLRSVD	DEG_APCC_DBOX_1	781:789	Mutation blocking phosphorylation signal	0.6667
p.S777R	VA-ES-BJ	bone	COSMIC	ERCGLRSVD	DEG_APCC_DBOX_1	781:789	Mutation blocking phosphorylation signal	0.6667
p.P779S	SIDM00188	Kidney Carcinoma	GDSC	ERCGLRSVD	DEG_APCC_DBOX_1	781:789	Mutation rewiring degron network	0.2778
p.P779S	SIDM01218	Other Solid Cancers	GDSC	ERCGLRSVD	DEG_APCC_DBOX_1	781:789	Mutation rewiring degron network	0.2778
p.P779S	SIDM01711	Non-Cancerous	GDSC	ERCGLRSVD	DEG_APCC_DBOX_1	781:789	Mutation rewiring degron network	0.2778
p.L792V	SIDM01322	Oral Cavity Carcinoma	GDSC	ERCGLRSVD	DEG_APCC_DBOX_1	781:789	Mutation rewiring degron network	0.25
p.L792V	SIDM01322	Oral Cavity Carcinoma	GDSC	VEVFSD	LIG_APCC_ABBA_1	798:803	Mutation rewiring degron network	0.1667
p.L792V	ACH-000735	Head and Neck Cancer	CCLE	ERCGLRSVD	DEG_APCC_DBOX_1	781:789	Mutation rewiring degron network	0.25
p.L792V	ACH-000735	Head and Neck Cancer	CCLE	VEVFSD	LIG_APCC_ABBA_1	798:803	Mutation rewiring degron network	0.1667
p.P341L	ACH-000208	Brain Cancer	CCLE	VGSTPETS	DEG_SCF_FBW7_1	347:354	Mutation rewiring degron network	0.1667
p.F808L	ACH-000667	Lung Cancer	CCLE	VEVFSD	LIG_APCC_ABBA_1	798:803	Mutation rewiring degron network	0.1944
p.P448T	ACH-000985	Colon/Colorectal Cancer	CCLE	LPATPTTS	DEG_SCF_FBW7_1	444:451	Mutation altering degron motif	0.7031
p.S362N	ACH-001991	Primary	CCLE	VGSTPETS	DEG_SCF_FBW7_1	347:354	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

STK11IP

UniProt ID: Q8N1F8

Entrez ID: 114790

Protein name: Serine/threonine-protein kinase 11-interacting protein (LKB1-interacting protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for STK11IP in