DegronMD - Q8N1F8(STK11IP)

FUNCTION: May regulate STK11/LKB1 function by controlling its subcellular localization. {ECO:0000269|PubMed:11741830}.

GO - Biological processes (BP): protein localization [GO:0008104]

GO - Molecular function (MF): protein kinase binding [GO:0019901]

GO - Cellular component (CC): azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D781Y	DO229038	LICA	ICGC	ERCGLRSVD	DEG_APCC_DBOX_1	781:789	Mutation altering degron motif	0.7325
p.G351D	TCGA-DD-AADL	LIHC	TCGA	VGSTPETS	DEG_SCF_FBW7_1	347:354	Mutation altering degron motif	0.7198
p.G351D	DO52237	LIHC	ICGC	VGSTPETS	DEG_SCF_FBW7_1	347:354	Mutation altering degron motif	0.7198
p.M350L	TCGA-MP-A4T7	LUAD	TCGA	VGSTPETS	DEG_SCF_FBW7_1	347:354	Mutation altering degron motif	0.711
p.M350L	DO45370	LUAD	ICGC	VGSTPETS	DEG_SCF_FBW7_1	347:354	Mutation altering degron motif	0.711
p.S348N	DO232224	PBCA	ICGC	VGSTPETS	DEG_SCF_FBW7_1	347:354	Mutation altering degron motif	0.7069
p.P448T	ACH-000985	Colon/Colorectal Cancer	CCLE	LPATPTTS	DEG_SCF_FBW7_1	444:451	Mutation altering degron motif	0.7031
p.P777L	TCGA-D9-A6EC	SKCM	TCGA	ERCGLRSVD	DEG_APCC_DBOX_1	781:789	Mutation blocking phosphorylation signal	0.6667
p.P777L	DO50291	SKCM	ICGC	ERCGLRSVD	DEG_APCC_DBOX_1	781:789	Mutation blocking phosphorylation signal	0.6667
p.S777R	SIDM01179	Other Sarcomas	GDSC	ERCGLRSVD	DEG_APCC_DBOX_1	781:789	Mutation blocking phosphorylation signal	0.6667
p.S777R	ACH-001702	Sarcoma	CCLE	ERCGLRSVD	DEG_APCC_DBOX_1	781:789	Mutation blocking phosphorylation signal	0.6667
p.S777R	VA-ES-BJ	bone	COSMIC	ERCGLRSVD	DEG_APCC_DBOX_1	781:789	Mutation blocking phosphorylation signal	0.6667
p.S802R	SIDM00330	Neuroblastoma	GDSC	VEVFSD	LIG_APCC_ABBA_1	798:803	Mutation altering degron motif	0.6316
p.S802R	SIDM00352	Ovarian Carcinoma	GDSC	VEVFSD	LIG_APCC_ABBA_1	798:803	Mutation altering degron motif	0.6316
p.S802R	SIDM00296	Small Cell Lung Carcinoma	GDSC	VEVFSD	LIG_APCC_ABBA_1	798:803	Mutation altering degron motif	0.6316
p.S802R	SIDM01093	Cervical Carcinoma	GDSC	VEVFSD	LIG_APCC_ABBA_1	798:803	Mutation altering degron motif	0.6316
p.S802R	SIDM01247	Burkitt's Lymphoma	GDSC	VEVFSD	LIG_APCC_ABBA_1	798:803	Mutation altering degron motif	0.6316
p.S802R	SIDM01680	Non-Cancerous	GDSC	VEVFSD	LIG_APCC_ABBA_1	798:803	Mutation altering degron motif	0.6316
p.S802R	SIDM00576	Acute Myeloid Leukemia	GDSC	VEVFSD	LIG_APCC_ABBA_1	798:803	Mutation altering degron motif	0.6316
p.S802R	SIDM00397	Acute Myeloid Leukemia	GDSC	VEVFSD	LIG_APCC_ABBA_1	798:803	Mutation altering degron motif	0.6316

Showing 1 to 20 of 49 entries

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Kaplan plot for STK11IP in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

STK11IP

UniProt ID: Q8N1F8

Entrez ID: 114790

Protein name: Serine/threonine-protein kinase 11-interacting protein (LKB1-interacting protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for STK11IP in