DegronMD

Uniprot ID: Q8N1F8

Source protein: Serine/threonine-protein kinase 11-interacting protein

Source gene: STK11IP

Class: DEG_SCF_FBW7_1

Location: 347:354

E3 ligase: FBXW7

DEGRON score: 0.9223

ASA_SCORE: 75.25

COIL: 0.903

CONS_SCORE: 0.2791

DSS_SCORE: 0.6881

HELIX: 0.0258

FCONS_SCORE: 0.9201

RIG_SCORE: 0.6006

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G351D	TCGA-DD-AADL	LIHC	TCGA	VGSTPETS	DEG_SCF_FBW7_1	0.7198
p.G351D	DO52237	LIHC	ICGC	VGSTPETS	DEG_SCF_FBW7_1	0.7198
p.M350L	TCGA-MP-A4T7	LUAD	TCGA	VGSTPETS	DEG_SCF_FBW7_1	0.711
p.M350L	DO45370	LUAD	ICGC	VGSTPETS	DEG_SCF_FBW7_1	0.711
p.D338V	DO230311	COCA	ICGC	VGSTPETS	DEG_SCF_FBW7_1	0.0833
p.S348N	DO232224	PBCA	ICGC	VGSTPETS	DEG_SCF_FBW7_1	0.7069
p.P341L	ACH-000208	Brain Cancer	CCLE	VGSTPETS	DEG_SCF_FBW7_1	0.1667
p.S362N	ACH-001991	Primary	CCLE	VGSTPETS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N1F8	Serine/threonine-protein kinase 11-interacting protein	DEG_SCF_FBW7_1	347:354	VGSTPETS	FBXW7	0.9223	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons