DegronMD

Uniprot ID: Q8N1F8

Source protein: Serine/threonine-protein kinase 11-interacting protein

Source gene: STK11IP

Class: LIG_APCC_ABBA_1

Location: 798:803

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8244

ASA_SCORE: 48

COIL: 0.361

CONS_SCORE: 0.5015

DSS_SCORE: 0.0412

HELIX: 0.01

FCONS_SCORE: 1.2622

RIG_SCORE: 0.8846

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E810V	TCGA-D8-A1X7	BRCA	TCGA	VEVFSD	LIG_APCC_ABBA_1	0.1389
p.E810V	DO1303	BRCA	ICGC	VEVFSD	LIG_APCC_ABBA_1	0.1389
p.R804Q	DO48232	ESCA	ICGC	VEVFSD	LIG_APCC_ABBA_1	0.3056
p.S802R	SIDM00330	Neuroblastoma	GDSC	VEVFSD	LIG_APCC_ABBA_1	0.6316
p.S802R	SIDM00352	Ovarian Carcinoma	GDSC	VEVFSD	LIG_APCC_ABBA_1	0.6316
p.S802R	SIDM00296	Small Cell Lung Carcinoma	GDSC	VEVFSD	LIG_APCC_ABBA_1	0.6316
p.S802R	SIDM01093	Cervical Carcinoma	GDSC	VEVFSD	LIG_APCC_ABBA_1	0.6316
p.S802R	SIDM01247	Burkitt's Lymphoma	GDSC	VEVFSD	LIG_APCC_ABBA_1	0.6316
p.S802R	SIDM01680	Non-Cancerous	GDSC	VEVFSD	LIG_APCC_ABBA_1	0.6316
p.S802R	SIDM00576	Acute Myeloid Leukemia	GDSC	VEVFSD	LIG_APCC_ABBA_1	0.6316
p.S802R	SIDM00397	Acute Myeloid Leukemia	GDSC	VEVFSD	LIG_APCC_ABBA_1	0.6316
p.S802R	SIDM00850	Gastric Carcinoma	GDSC	VEVFSD	LIG_APCC_ABBA_1	0.6316
p.S802R	SIDM01447	Glioblastoma	GDSC	VEVFSD	LIG_APCC_ABBA_1	0.6316
p.L792V	SIDM01322	Oral Cavity Carcinoma	GDSC	VEVFSD	LIG_APCC_ABBA_1	0.1667
p.L792V	ACH-000735	Head and Neck Cancer	CCLE	VEVFSD	LIG_APCC_ABBA_1	0.1667
p.F808L	ACH-000667	Lung Cancer	CCLE	VEVFSD	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N1F8	Serine/threonine-protein kinase 11-interacting protein	LIG_APCC_ABBA_1	798:803	VEVFSD	APC,CDC20,FZR1	0.8244	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons