DegronMD

Uniprot ID: Q8N1F8

Source protein: Serine/threonine-protein kinase 11-interacting protein

Source gene: STK11IP

Class: DEG_SCF_FBW7_1

Location: 444:451

E3 ligase: FBXW7

DEGRON score: 0.9233

ASA_SCORE: 84.325

COIL: 0.9394

CONS_SCORE: 0.2766

DSS_SCORE: 0.7937

HELIX: 0.0191

FCONS_SCORE: 0.7255

RIG_SCORE: 0.5502

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R434L	TCGA-DA-A1I1	SKCM	TCGA	LPATPTTS	DEG_SCF_FBW7_1	0.0556
p.R434L	DO37966	SKCM	ICGC	LPATPTTS	DEG_SCF_FBW7_1	0.0556
p.L455R	TCGA-ZF-AA56	BLCA	TCGA	LPATPTTS	DEG_SCF_FBW7_1	0.2222
p.L455R	DO219099	BLCA	ICGC	LPATPTTS	DEG_SCF_FBW7_1	0.2222
p.R439C	DO231075	LUSC	ICGC	LPATPTTS	DEG_SCF_FBW7_1	0.1944
p.R434W	DO222363	MELA	ICGC	LPATPTTS	DEG_SCF_FBW7_1	0.0556
p.R434W	DO222494	MELA	ICGC	LPATPTTS	DEG_SCF_FBW7_1	0.0556
p.G438S	DO232224	PBCA	ICGC	LPATPTTS	DEG_SCF_FBW7_1	0.1667
p.P448T	ACH-000985	Colon/Colorectal Cancer	CCLE	LPATPTTS	DEG_SCF_FBW7_1	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N1F8	Serine/threonine-protein kinase 11-interacting protein	DEG_SCF_FBW7_1	444:451	LPATPTTS	FBXW7	0.9233	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons