DegronMD

Uniprot ID: Q9UKL0

Source protein: REST corepressor 1

Source gene: RCOR1

Class: DEG_APCC_DBOX_1

Location: 129:137

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9871

ASA_SCORE: 71.1111

COIL: 0.5648

CONS_SCORE: 0.4757

DSS_SCORE: 0.4209

HELIX: 0.2451

FCONS_SCORE: 1.0614

RIG_SCORE: 0.7681

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R126H	TCGA-HU-8602	STAD	TCGA	ERDNLGMLV	DEG_APCC_DBOX_1	0.25
p.R126H	DO233641	GACA	ICGC	ERDNLGMLV	DEG_APCC_DBOX_1	0.25
p.R126H	DO228138	PBCA	ICGC	ERDNLGMLV	DEG_APCC_DBOX_1	0.25
p.R126H	DO47829	STAD	ICGC	ERDNLGMLV	DEG_APCC_DBOX_1	0.25
p.R130W	DO10806	EOPC	ICGC	ERDNLGMLV	DEG_APCC_DBOX_1	0.8634
p.W138L	DO228978	LICA	ICGC	ERDNLGMLV	DEG_APCC_DBOX_1	0.3056
p.G134V	DO229045	LICA	ICGC	ERDNLGMLV	DEG_APCC_DBOX_1	0.6421
p.D119Y	DO229009	LICA	ICGC	ERDNLGMLV	DEG_APCC_DBOX_1	0.0556
p.Q142E	DO27879	ORCA	ICGC	ERDNLGMLV	DEG_APCC_DBOX_1	0.1944
p.L133F	DO229456	SKCA	ICGC	ERDNLGMLV	DEG_APCC_DBOX_1	0.6981
p.R125I	SIDM01611	Endometrial Carcinoma	GDSC	ERDNLGMLV	DEG_APCC_DBOX_1	0.2222
p.R125I	ACH-000996	Endometrial/Uterine Cancer	CCLE	ERDNLGMLV	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKL0	REST corepressor 1	DEG_APCC_DBOX_1	129:137	ERDNLGMLV	APC,CDC20,FZR1	0.9871	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons