DegronMD

Uniprot ID: Q9H4L5

Source protein: Oxysterol-binding protein-related protein 3

Source gene: OSBPL3

Class: DEG_APCC_DBOX_1

Location: 357:365

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.559

ASA_SCORE: 92.4667

COIL: 0.0508

CONS_SCORE: 0.3483

DSS_SCORE: 0.3875

HELIX: 0.9498

FCONS_SCORE: 1.1126

RIG_SCORE: 0.8128

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E359K	TCGA-50-6590	LUAD	TCGA	EREKLKQLM	DEG_APCC_DBOX_1	0.591
p.R348S	TCGA-86-8056	LUAD	TCGA	EREKLKQLM	DEG_APCC_DBOX_1	0.0833
p.A356V	TCGA-A5-A1OF	UCEC	TCGA	EREKLKQLM	DEG_APCC_DBOX_1	0.3056
p.A356V	DO42568	UCEC	ICGC	EREKLKQLM	DEG_APCC_DBOX_1	0.3056
p.R358I	TCGA-AG-A002	READ	TCGA	EREKLKQLM	DEG_APCC_DBOX_1	0.8102
p.P373R	TCGA-BR-A4PE	STAD	TCGA	EREKLKQLM	DEG_APCC_DBOX_1	0.1111
p.P373R	DO47773	STAD	ICGC	EREKLKQLM	DEG_APCC_DBOX_1	0.1111
p.E357K	TCGA-HU-8604	STAD	TCGA	EREKLKQLM	DEG_APCC_DBOX_1	0.591
p.E357K	DO47907	STAD	ICGC	EREKLKQLM	DEG_APCC_DBOX_1	0.591
p.S349L	TCGA-VS-A9UZ	CESC	TCGA	EREKLKQLM	DEG_APCC_DBOX_1	0.1111
p.R366C	DO222905	BTCA	ICGC	EREKLKQLM	DEG_APCC_DBOX_1	0.3056
p.R368H	DO52450	COCA	ICGC	EREKLKQLM	DEG_APCC_DBOX_1	0.25
p.R368H	DO41235	UCEC	ICGC	EREKLKQLM	DEG_APCC_DBOX_1	0.25
p.R366H	DO228949	LICA	ICGC	EREKLKQLM	DEG_APCC_DBOX_1	0.3056
p.T361K	DO228952	LICA	ICGC	EREKLKQLM	DEG_APCC_DBOX_1	0.7306
p.A356D	DO229031	LICA	ICGC	EREKLKQLM	DEG_APCC_DBOX_1	0.3056
p.P373S	DO220884	MELA	ICGC	EREKLKQLM	DEG_APCC_DBOX_1	0.1111
p.Q359K	DO47303	SKCM	ICGC	EREKLKQLM	DEG_APCC_DBOX_1	0.6944
p.A372T	DO41999	UCEC	ICGC	EREKLKQLM	DEG_APCC_DBOX_1	0.5833
p.S374P	SIDM01020	Plasma Cell Myeloma	GDSC	EREKLKQLM	DEG_APCC_DBOX_1	0.5278
p.S374P	SIDM00434	Plasma Cell Myeloma	GDSC	EREKLKQLM	DEG_APCC_DBOX_1	0.5278
p.S374P	SIDM00577	Neuroblastoma	GDSC	EREKLKQLM	DEG_APCC_DBOX_1	0.5278
p.S374P	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	EREKLKQLM	DEG_APCC_DBOX_1	0.5278
p.S374P	SIDM00302	Other Solid Cancers	GDSC	EREKLKQLM	DEG_APCC_DBOX_1	0.5278
p.S374P	SIDM01368	Gastric Carcinoma	GDSC	EREKLKQLM	DEG_APCC_DBOX_1	0.5278
p.S374P	SIDM01776	Plasma Cell Myeloma	GDSC	EREKLKQLM	DEG_APCC_DBOX_1	0.5278
p.S374P	KYSE-510	oesophagus	COSMIC	EREKLKQLM	DEG_APCC_DBOX_1	0.5278
p.S374P	MOLP-8	haematopoietic_and_lymphoid_tissue	COSMIC	EREKLKQLM	DEG_APCC_DBOX_1	0.5278
p.S374P	KMS-12-BM	haematopoietic_and_lymphoid_tissue	COSMIC	EREKLKQLM	DEG_APCC_DBOX_1	0.5278
p.S374P	KGN	ovary	COSMIC	EREKLKQLM	DEG_APCC_DBOX_1	0.5278
p.S374P	NH-12	autonomic_ganglia	COSMIC	EREKLKQLM	DEG_APCC_DBOX_1	0.5278
p.P373L	ACH-002508	Skin Cancer	CCLE	EREKLKQLM	DEG_APCC_DBOX_1	0.1111
p.L365V	SF295	central_nervous_system	COSMIC	EREKLKQLM	DEG_APCC_DBOX_1	0.6765

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: EREKLKQLM

Degron related mutations and impact score

Drug responses associated with OSBPL3 mutations

All proteins holding degron of EREKLKQLM

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H4L5	Oxysterol-binding protein-related protein 3	DEG_APCC_DBOX_1	357:365	EREKLKQLM	APC,CDC20,FZR1	0.559	More...