DegronMD - Q9H4L5(OSBPL3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E359K	TCGA-50-6590	LUAD	TCGA	EREKLKQLM	DEG_APCC_DBOX_1	357:365	Mutation altering degron motif	0.591
p.R348S	TCGA-86-8056	LUAD	TCGA	EREKLKQLM	DEG_APCC_DBOX_1	357:365	Mutation rewiring degron network	0.0833
p.A508V	TCGA-A5-A0G2	UCEC	TCGA	ERQTLGPVL	DEG_APCC_DBOX_1	494:502	Mutation rewiring degron network	0.1667
p.A356V	TCGA-A5-A1OF	UCEC	TCGA	EREKLKQLM	DEG_APCC_DBOX_1	357:365	Mutation rewiring degron network	0.3056
p.A356V	DO42568	UCEC	ICGC	EREKLKQLM	DEG_APCC_DBOX_1	357:365	Mutation rewiring degron network	0.3056
p.R358I	TCGA-AG-A002	READ	TCGA	EREKLKQLM	DEG_APCC_DBOX_1	357:365	Mutation altering degron motif	0.8102
p.R495I	TCGA-AP-A1DV	UCEC	TCGA	ERQTLGPVL	DEG_APCC_DBOX_1	494:502	Mutation altering degron motif	0.8102
p.E507K	TCGA-AX-A2HC	UCEC	TCGA	ERQTLGPVL	DEG_APCC_DBOX_1	494:502	Mutation rewiring degron network	0.1944
p.P373R	TCGA-BR-A4PE	STAD	TCGA	EREKLKQLM	DEG_APCC_DBOX_1	357:365	Mutation rewiring degron network	0.1111
p.P373R	DO47773	STAD	ICGC	EREKLKQLM	DEG_APCC_DBOX_1	357:365	Mutation rewiring degron network	0.1111
p.E357K	TCGA-HU-8604	STAD	TCGA	EREKLKQLM	DEG_APCC_DBOX_1	357:365	Mutation altering degron motif	0.591
p.E357K	DO47907	STAD	ICGC	EREKLKQLM	DEG_APCC_DBOX_1	357:365	Mutation altering degron motif	0.591
p.S349L	TCGA-VS-A9UZ	CESC	TCGA	EREKLKQLM	DEG_APCC_DBOX_1	357:365	Mutation rewiring degron network	0.1111
p.D508N	DO222871	BTCA	ICGC	ERQTLGPVL	DEG_APCC_DBOX_1	494:502	Mutation rewiring degron network	0.1667
p.R366C	DO222905	BTCA	ICGC	EREKLKQLM	DEG_APCC_DBOX_1	357:365	Mutation rewiring degron network	0.3056
p.R368H	DO52450	COCA	ICGC	EREKLKQLM	DEG_APCC_DBOX_1	357:365	Mutation rewiring degron network	0.25
p.R368H	DO41235	UCEC	ICGC	EREKLKQLM	DEG_APCC_DBOX_1	357:365	Mutation rewiring degron network	0.25
p.N504D	DO233918	GACA	ICGC	ERQTLGPVL	DEG_APCC_DBOX_1	494:502	Mutation blocking phosphorylation signal	0.7222
p.K502N	DO10880	GBM	ICGC	ERQTLGPVL	DEG_APCC_DBOX_1	494:502	Mutation altering degron motif	0.6918
p.R366H	DO228949	LICA	ICGC	EREKLKQLM	DEG_APCC_DBOX_1	357:365	Mutation rewiring degron network	0.3056
p.T361K	DO228952	LICA	ICGC	EREKLKQLM	DEG_APCC_DBOX_1	357:365	Mutation altering degron motif	0.7306
p.A356D	DO229031	LICA	ICGC	EREKLKQLM	DEG_APCC_DBOX_1	357:365	Mutation rewiring degron network	0.3056
p.V507L	DO27128	LUSC	ICGC	ERQTLGPVL	DEG_APCC_DBOX_1	494:502	Mutation rewiring degron network	0.1944
p.P373S	DO220884	MELA	ICGC	EREKLKQLM	DEG_APCC_DBOX_1	357:365	Mutation rewiring degron network	0.1111
p.Q359K	DO47303	SKCM	ICGC	EREKLKQLM	DEG_APCC_DBOX_1	357:365	Mutation altering degron motif	0.6944
p.S505F	DO47362	SKCM	ICGC	ERQTLGPVL	DEG_APCC_DBOX_1	494:502	Mutation rewiring degron network	0.25
p.S505F	DO51267	SKCM	ICGC	ERQTLGPVL	DEG_APCC_DBOX_1	494:502	Mutation rewiring degron network	0.25
p.L492M	DO219774	UCEC	ICGC	ERQTLGPVL	DEG_APCC_DBOX_1	494:502	Mutation rewiring degron network	0.2778
p.G506R	DO48170	UCEC	ICGC	ERQTLGPVL	DEG_APCC_DBOX_1	494:502	Mutation rewiring degron network	0.2222
p.L496P	DO40889	UCEC	ICGC	ERQTLGPVL	DEG_APCC_DBOX_1	494:502	Mutation altering degron motif	0.7582
p.A372T	DO41999	UCEC	ICGC	EREKLKQLM	DEG_APCC_DBOX_1	357:365	Mutation blocking phosphorylation signal	0.5833
p.S374P	SIDM01020	Plasma Cell Myeloma	GDSC	EREKLKQLM	DEG_APCC_DBOX_1	357:365	Mutation blocking phosphorylation signal	0.5278
p.S374P	SIDM00434	Plasma Cell Myeloma	GDSC	EREKLKQLM	DEG_APCC_DBOX_1	357:365	Mutation blocking phosphorylation signal	0.5278
p.S374P	SIDM00577	Neuroblastoma	GDSC	EREKLKQLM	DEG_APCC_DBOX_1	357:365	Mutation blocking phosphorylation signal	0.5278
p.S374P	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	EREKLKQLM	DEG_APCC_DBOX_1	357:365	Mutation blocking phosphorylation signal	0.5278
p.S374P	SIDM00302	Other Solid Cancers	GDSC	EREKLKQLM	DEG_APCC_DBOX_1	357:365	Mutation blocking phosphorylation signal	0.5278
p.S374P	SIDM01368	Gastric Carcinoma	GDSC	EREKLKQLM	DEG_APCC_DBOX_1	357:365	Mutation blocking phosphorylation signal	0.5278
p.S374P	SIDM01776	Plasma Cell Myeloma	GDSC	EREKLKQLM	DEG_APCC_DBOX_1	357:365	Mutation blocking phosphorylation signal	0.5278
p.S374P	KYSE-510	oesophagus	COSMIC	EREKLKQLM	DEG_APCC_DBOX_1	357:365	Mutation blocking phosphorylation signal	0.5278
p.S374P	MOLP-8	haematopoietic and lymphoid tissue	COSMIC	EREKLKQLM	DEG_APCC_DBOX_1	357:365	Mutation blocking phosphorylation signal	0.5278
p.S374P	KMS-12-BM	haematopoietic and lymphoid tissue	COSMIC	EREKLKQLM	DEG_APCC_DBOX_1	357:365	Mutation blocking phosphorylation signal	0.5278
p.S374P	KGN	ovary	COSMIC	EREKLKQLM	DEG_APCC_DBOX_1	357:365	Mutation blocking phosphorylation signal	0.5278
p.S374P	NH-12	autonomic ganglia	COSMIC	EREKLKQLM	DEG_APCC_DBOX_1	357:365	Mutation blocking phosphorylation signal	0.5278
p.P373L	ACH-002508	Skin Cancer	CCLE	EREKLKQLM	DEG_APCC_DBOX_1	357:365	Mutation rewiring degron network	0.1111
p.L365V	SF295	central nervous system	COSMIC	EREKLKQLM	DEG_APCC_DBOX_1	357:365	Mutation altering degron motif	0.6765
p.K511E	SNU-81	large intestine	COSMIC	ERQTLGPVL	DEG_APCC_DBOX_1	494:502	Mutation rewiring degron network	0.0833
p.A506T	SKN	soft tissue	COSMIC	ERQTLGPVL	DEG_APCC_DBOX_1	494:502	Mutation rewiring degron network	0.2222
p.K506E	SNU-81	large intestine	COSMIC	ERQTLGPVL	DEG_APCC_DBOX_1	494:502	Mutation rewiring degron network	0.2222
p.A487T	BFTC-905	urinary tract	COSMIC	ERQTLGPVL	DEG_APCC_DBOX_1	494:502	Mutation rewiring degron network	0.1389

Kaplan plot for OSBPL3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

OSBPL3

UniProt ID: Q9H4L5

Entrez ID: 26031

Protein name: Oxysterol-binding protein-related protein 3 (ORP-3) (OSBP-related protein 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for OSBPL3 in