DegronMD

Uniprot ID: Q9H4L5

Source protein: Oxysterol-binding protein-related protein 3

Source gene: OSBPL3

Class: DEG_APCC_DBOX_1

Location: 494:502

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9976

ASA_SCORE: 80.9444

COIL: 0.7533

CONS_SCORE: 0.3057

DSS_SCORE: 0.5692

HELIX: 0.1539

FCONS_SCORE: 0.991

RIG_SCORE: 0.7118

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A508V	TCGA-A5-A0G2	UCEC	TCGA	ERQTLGPVL	DEG_APCC_DBOX_1	0.1667
p.R495I	TCGA-AP-A1DV	UCEC	TCGA	ERQTLGPVL	DEG_APCC_DBOX_1	0.8102
p.E507K	TCGA-AX-A2HC	UCEC	TCGA	ERQTLGPVL	DEG_APCC_DBOX_1	0.1944
p.D508N	DO222871	BTCA	ICGC	ERQTLGPVL	DEG_APCC_DBOX_1	0.1667
p.N504D	DO233918	GACA	ICGC	ERQTLGPVL	DEG_APCC_DBOX_1	0.7222
p.K502N	DO10880	GBM	ICGC	ERQTLGPVL	DEG_APCC_DBOX_1	0.6918
p.V507L	DO27128	LUSC	ICGC	ERQTLGPVL	DEG_APCC_DBOX_1	0.1944
p.S505F	DO47362	SKCM	ICGC	ERQTLGPVL	DEG_APCC_DBOX_1	0.25
p.S505F	DO51267	SKCM	ICGC	ERQTLGPVL	DEG_APCC_DBOX_1	0.25
p.L492M	DO219774	UCEC	ICGC	ERQTLGPVL	DEG_APCC_DBOX_1	0.2778
p.G506R	DO48170	UCEC	ICGC	ERQTLGPVL	DEG_APCC_DBOX_1	0.2222
p.L496P	DO40889	UCEC	ICGC	ERQTLGPVL	DEG_APCC_DBOX_1	0.7582
p.K511E	SNU-81	large_intestine	COSMIC	ERQTLGPVL	DEG_APCC_DBOX_1	0.0833
p.A506T	SKN	soft_tissue	COSMIC	ERQTLGPVL	DEG_APCC_DBOX_1	0.2222
p.K506E	SNU-81	large_intestine	COSMIC	ERQTLGPVL	DEG_APCC_DBOX_1	0.2222
p.A487T	BFTC-905	urinary_tract	COSMIC	ERQTLGPVL	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H4L5	Oxysterol-binding protein-related protein 3	DEG_APCC_DBOX_1	494:502	ERQTLGPVL	APC,CDC20,FZR1	0.9976	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons