DegronMD

Uniprot ID: Q5U5R9

Source protein: Probable E3 ubiquitin-protein ligase HECTD2

Source gene: HECTD2

Class: DEG_APCC_DBOX_1

Location: 30:38

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9806

ASA_SCORE: 84.8556

COIL: 0.7432

CONS_SCORE: 0.3457

DSS_SCORE: 0.5979

HELIX: 0.1183

FCONS_SCORE: 1.0079

RIG_SCORE: 0.7124

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G47C	TCGA-EE-A2GE	SKCM	TCGA	EREKLPPIV	DEG_APCC_DBOX_1	0.0833
p.G47C	DO38016	SKCM	ICGC	EREKLPPIV	DEG_APCC_DBOX_1	0.0833
p.D29H	DO51886	BLCA	ICGC	EREKLPPIV	DEG_APCC_DBOX_1	0.3056
p.D29Y	DO223588	BLCA	ICGC	EREKLPPIV	DEG_APCC_DBOX_1	0.3056
p.D29Y	DO26467	LUSC	ICGC	EREKLPPIV	DEG_APCC_DBOX_1	0.3056
p.K32N	DO219022	BLCA	ICGC	EREKLPPIV	DEG_APCC_DBOX_1	0.6918
p.R27T	DO49985	CESC	ICGC	EREKLPPIV	DEG_APCC_DBOX_1	0.3611
p.E22D	DO228948	LICA	ICGC	EREKLPPIV	DEG_APCC_DBOX_1	0.1111
p.G43C	DO47607	SKCM	ICGC	EREKLPPIV	DEG_APCC_DBOX_1	0.1944
p.A44V	DO229268	THCA	ICGC	EREKLPPIV	DEG_APCC_DBOX_1	0.1667
p.V38I	ACH-000628	Lung Cancer	CCLE	EREKLPPIV	DEG_APCC_DBOX_1	0.5965
p.A46T	SNU-175	large_intestine	COSMIC	EREKLPPIV	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5U5R9	Probable E3 ubiquitin-protein ligase HECTD2	DEG_APCC_DBOX_1	30:38	EREKLPPIV	APC,CDC20,FZR1	0.9806	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons