DegronMD - Q5U5R9(HECTD2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G47C	TCGA-EE-A2GE	SKCM	TCGA	EREKLPPIV	DEG_APCC_DBOX_1	30:38	Mutation rewiring degron network	0.0833
p.G47C	DO38016	SKCM	ICGC	EREKLPPIV	DEG_APCC_DBOX_1	30:38	Mutation rewiring degron network	0.0833
p.D29H	DO51886	BLCA	ICGC	EREKLPPIV	DEG_APCC_DBOX_1	30:38	Mutation rewiring degron network	0.3056
p.D29Y	DO223588	BLCA	ICGC	EREKLPPIV	DEG_APCC_DBOX_1	30:38	Mutation rewiring degron network	0.3056
p.D29Y	DO26467	LUSC	ICGC	EREKLPPIV	DEG_APCC_DBOX_1	30:38	Mutation rewiring degron network	0.3056
p.K32N	DO219022	BLCA	ICGC	EREKLPPIV	DEG_APCC_DBOX_1	30:38	Mutation altering degron motif	0.6918
p.R27T	DO49985	CESC	ICGC	EREKLPPIV	DEG_APCC_DBOX_1	30:38	Mutation substituting flanking lysine	0.3611
p.P19A	DO229010	COCA	ICGC	SEAVRVPSP	DEG_COP1_1	2:10	Mutation rewiring degron network	0.0833
p.P19A	DO229013	COCA	ICGC	SEAVRVPSP	DEG_COP1_1	2:10	Mutation rewiring degron network	0.0833
p.P19A	DO229016	COCA	ICGC	SEAVRVPSP	DEG_COP1_1	2:10	Mutation rewiring degron network	0.0833
p.P19A	DO229003	COCA	ICGC	SEAVRVPSP	DEG_COP1_1	2:10	Mutation rewiring degron network	0.0833
p.P19A	DO229005	COCA	ICGC	SEAVRVPSP	DEG_COP1_1	2:10	Mutation rewiring degron network	0.0833
p.E22D	DO228948	LICA	ICGC	EREKLPPIV	DEG_APCC_DBOX_1	30:38	Mutation rewiring degron network	0.1111
p.S17I	DO228986	LICA	ICGC	SEAVRVPSP	DEG_COP1_1	2:10	Mutation rewiring degron network	0.1389
p.G43C	DO47607	SKCM	ICGC	EREKLPPIV	DEG_APCC_DBOX_1	30:38	Mutation rewiring degron network	0.1944
p.A44V	DO229268	THCA	ICGC	EREKLPPIV	DEG_APCC_DBOX_1	30:38	Mutation rewiring degron network	0.1667
p.R12W	DO41235	UCEC	ICGC	SEAVRVPSP	DEG_COP1_1	2:10	Mutation rewiring degron network	0.2778
p.L6I	DO41488	UCEC	ICGC	SEAVRVPSP	DEG_COP1_1	2:10	Mutation altering degron motif	0.7174
p.V38I	ACH-000628	Lung Cancer	CCLE	EREKLPPIV	DEG_APCC_DBOX_1	30:38	Mutation altering degron motif	0.5965
p.H14N	ES-2	ovary	COSMIC	SEAVRVPSP	DEG_COP1_1	2:10	Mutation rewiring degron network	0.2222
p.A46T	SNU-175	large intestine	COSMIC	EREKLPPIV	DEG_APCC_DBOX_1	30:38	Mutation rewiring degron network	0.1111

Kaplan plot for HECTD2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HECTD2

UniProt ID: Q5U5R9

Entrez ID: 143279

Protein name: Probable E3 ubiquitin-protein ligase HECTD2 (EC 2.3.2.26) (HECT domain-containing protein 2) (HECT-type E3 ubiquitin transferase HECTD2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HECTD2 in