DegronMD

Uniprot ID: Q5U5R9

Source protein: Probable E3 ubiquitin-protein ligase HECTD2

Source gene: HECTD2

Class: DEG_COP1_1

Location: 2:10

E3 ligase: COP1

DEGRON score: 0.7482

ASA_SCORE: 91.1556

COIL: 0.9104

CONS_SCORE: 0.3491

DSS_SCORE: 0.7198

HELIX: 0.0483

FCONS_SCORE: 1.0398

RIG_SCORE: 0.6772

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P19A	DO229010	COCA	ICGC	SEAVRVPSP	DEG_COP1_1	0.0833
p.P19A	DO229013	COCA	ICGC	SEAVRVPSP	DEG_COP1_1	0.0833
p.P19A	DO229016	COCA	ICGC	SEAVRVPSP	DEG_COP1_1	0.0833
p.P19A	DO229003	COCA	ICGC	SEAVRVPSP	DEG_COP1_1	0.0833
p.P19A	DO229005	COCA	ICGC	SEAVRVPSP	DEG_COP1_1	0.0833
p.S17I	DO228986	LICA	ICGC	SEAVRVPSP	DEG_COP1_1	0.1389
p.R12W	DO41235	UCEC	ICGC	SEAVRVPSP	DEG_COP1_1	0.2778
p.L6I	DO41488	UCEC	ICGC	SEAVRVPSP	DEG_COP1_1	0.7174
p.H14N	ES-2	ovary	COSMIC	SEAVRVPSP	DEG_COP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5U5R9	Probable E3 ubiquitin-protein ligase HECTD2	DEG_COP1_1	2:10	SEAVRVPSP	COP1	0.7482	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons