DegronMD

Uniprot ID: Q9BSJ8

Source protein: Extended synaptotagmin-1

Source gene: ESYT1

Class: DEG_APCC_DBOX_1

Location: 1069:1077

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8721

ASA_SCORE: 68.9111

COIL: 0.4486

CONS_SCORE: 0.3925

DSS_SCORE: 0.2936

HELIX: 0.0243

FCONS_SCORE: 1.1454

RIG_SCORE: 0.7973

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1071F	TCGA-B5-A11E	UCEC	TCGA	ERELLGKVQ	DEG_APCC_DBOX_1	0.7982
p.R1070H	DO10858	ESAD	ICGC	ERELLGKVQ	DEG_APCC_DBOX_1	0.8244
p.S1061F	DO41644	UCEC	ICGC	ERELLGKVQ	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BSJ8	Extended synaptotagmin-1	DEG_APCC_DBOX_1	1069:1077	ERELLGKVQ	APC,CDC20,FZR1	0.8721	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons