DegronMD - Q9BSJ8(ESYT1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1071F	TCGA-B5-A11E	UCEC	TCGA	ERELLGKVQ	DEG_APCC_DBOX_1	1069:1077	Mutation altering degron motif	0.7982
p.P962T	TCGA-MP-A4TK	LUAD	TCGA	LRQRLTHVD	DEG_APCC_DBOX_1	954:962	Mutation altering degron motif	0.7031
p.P968L	DO225294	BRCA	ICGC	LRQRLTHVD	DEG_APCC_DBOX_1	954:962	Mutation rewiring degron network	0.1667
p.P968L	DO227830	BRCA	ICGC	LRQRLTHVD	DEG_APCC_DBOX_1	954:962	Mutation rewiring degron network	0.1667
p.R1070H	DO10858	ESAD	ICGC	ERELLGKVQ	DEG_APCC_DBOX_1	1069:1077	Mutation altering degron motif	0.8244
p.A967V	DO22237	LGG	ICGC	LRQRLTHVD	DEG_APCC_DBOX_1	954:962	Mutation rewiring degron network	0.1944
p.R955L	DO229041	LICA	ICGC	LRQRLTHVD	DEG_APCC_DBOX_1	954:962	Mutation altering degron motif	0.8428
p.A969V	DO24527	LUAD	ICGC	LRQRLTHVD	DEG_APCC_DBOX_1	954:962	Mutation rewiring degron network	0.1389
p.P952T	DO45384	LUAD	ICGC	LRQRLTHVD	DEG_APCC_DBOX_1	954:962	Mutation rewiring degron network	0.2778
p.D962N	DO50723	ORCA	ICGC	LRQRLTHVD	DEG_APCC_DBOX_1	954:962	Mutation altering degron motif	0.5821
p.S1061F	DO41644	UCEC	ICGC	ERELLGKVQ	DEG_APCC_DBOX_1	1069:1077	Mutation rewiring degron network	0.1111
p.G970E	DO41199	UCEC	ICGC	LRQRLTHVD	DEG_APCC_DBOX_1	954:962	Mutation rewiring degron network	0.1111
p.S951L	SIDM00789	Colorectal Carcinoma	GDSC	LRQRLTHVD	DEG_APCC_DBOX_1	954:962	Mutation rewiring degron network	0.25
p.S951L	SIDM00329	Hodgkin's Lymphoma	GDSC	LRQRLTHVD	DEG_APCC_DBOX_1	954:962	Mutation rewiring degron network	0.25
p.R967H	SIDM00789	Colorectal Carcinoma	GDSC	LRQRLTHVD	DEG_APCC_DBOX_1	954:962	Mutation rewiring degron network	0.1944
p.R967H	ACH-000954	Endometrial/Uterine Cancer	CCLE	LRQRLTHVD	DEG_APCC_DBOX_1	954:962	Mutation rewiring degron network	0.1944
p.R967H	ACH-000997	Colon/Colorectal Cancer	CCLE	LRQRLTHVD	DEG_APCC_DBOX_1	954:962	Mutation rewiring degron network	0.1944
p.R967H	ACH-001061	Colon/Colorectal Cancer	CCLE	LRQRLTHVD	DEG_APCC_DBOX_1	954:962	Mutation rewiring degron network	0.1944
p.R967H	HCT-15	large intestine	COSMIC	LRQRLTHVD	DEG_APCC_DBOX_1	954:962	Mutation rewiring degron network	0.1944
p.S945R	SIDM01146	Gastric Carcinoma	GDSC	LRQRLTHVD	DEG_APCC_DBOX_1	954:962	Mutation rewiring degron network	0.0833
p.S945R	ACH-000932	Gastric Cancer	CCLE	LRQRLTHVD	DEG_APCC_DBOX_1	954:962	Mutation rewiring degron network	0.0833
p.S945R	NCI-SNU-1	stomach	COSMIC	LRQRLTHVD	DEG_APCC_DBOX_1	954:962	Mutation rewiring degron network	0.0833
p.L965I	CHSA8926	bone	COSMIC	LRQRLTHVD	DEG_APCC_DBOX_1	954:962	Mutation rewiring degron network	0.25
p.R957H	HCT-15	large intestine	COSMIC	LRQRLTHVD	DEG_APCC_DBOX_1	954:962	Mutation altering degron motif	0.7133

Kaplan plot for ESYT1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ESYT1

UniProt ID: Q9BSJ8

Entrez ID: 23344

Protein name: Extended synaptotagmin-1 (E-Syt1) (Membrane-bound C2 domain-containing protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ESYT1 in