DegronMD

Uniprot ID: Q9BSJ8

Source protein: Extended synaptotagmin-1

Source gene: ESYT1

Class: DEG_APCC_DBOX_1

Location: 954:962

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5336

ASA_SCORE: 77.8222

COIL: 0.5018

CONS_SCORE: 0.267

DSS_SCORE: 0.5647

HELIX: 0.4437

FCONS_SCORE: 0.9129

RIG_SCORE: 0.7087

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P962T	TCGA-MP-A4TK	LUAD	TCGA	LRQRLTHVD	DEG_APCC_DBOX_1	0.7031
p.P968L	DO225294	BRCA	ICGC	LRQRLTHVD	DEG_APCC_DBOX_1	0.1667
p.P968L	DO227830	BRCA	ICGC	LRQRLTHVD	DEG_APCC_DBOX_1	0.1667
p.A967V	DO22237	LGG	ICGC	LRQRLTHVD	DEG_APCC_DBOX_1	0.1944
p.R955L	DO229041	LICA	ICGC	LRQRLTHVD	DEG_APCC_DBOX_1	0.8428
p.A969V	DO24527	LUAD	ICGC	LRQRLTHVD	DEG_APCC_DBOX_1	0.1389
p.P952T	DO45384	LUAD	ICGC	LRQRLTHVD	DEG_APCC_DBOX_1	0.2778
p.D962N	DO50723	ORCA	ICGC	LRQRLTHVD	DEG_APCC_DBOX_1	0.5821
p.G970E	DO41199	UCEC	ICGC	LRQRLTHVD	DEG_APCC_DBOX_1	0.1111
p.S951L	SIDM00789	Colorectal Carcinoma	GDSC	LRQRLTHVD	DEG_APCC_DBOX_1	0.25
p.S951L	SIDM00329	Hodgkin's Lymphoma	GDSC	LRQRLTHVD	DEG_APCC_DBOX_1	0.25
p.R967H	SIDM00789	Colorectal Carcinoma	GDSC	LRQRLTHVD	DEG_APCC_DBOX_1	0.1944
p.R967H	ACH-000954	Endometrial/Uterine Cancer	CCLE	LRQRLTHVD	DEG_APCC_DBOX_1	0.1944
p.R967H	ACH-000997	Colon/Colorectal Cancer	CCLE	LRQRLTHVD	DEG_APCC_DBOX_1	0.1944
p.R967H	ACH-001061	Colon/Colorectal Cancer	CCLE	LRQRLTHVD	DEG_APCC_DBOX_1	0.1944
p.R967H	HCT-15	large_intestine	COSMIC	LRQRLTHVD	DEG_APCC_DBOX_1	0.1944
p.S945R	SIDM01146	Gastric Carcinoma	GDSC	LRQRLTHVD	DEG_APCC_DBOX_1	0.0833
p.S945R	ACH-000932	Gastric Cancer	CCLE	LRQRLTHVD	DEG_APCC_DBOX_1	0.0833
p.S945R	NCI-SNU-1	stomach	COSMIC	LRQRLTHVD	DEG_APCC_DBOX_1	0.0833
p.L965I	CHSA8926	bone	COSMIC	LRQRLTHVD	DEG_APCC_DBOX_1	0.25
p.R957H	HCT-15	large_intestine	COSMIC	LRQRLTHVD	DEG_APCC_DBOX_1	0.7133

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BSJ8	Extended synaptotagmin-1	DEG_APCC_DBOX_1	954:962	LRQRLTHVD	APC,CDC20,FZR1	0.5336	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons