DegronMD

Uniprot ID: Q8TE12

Source protein: LIM homeobox transcription factor 1-alpha

Source gene: LMX1A

Class: DEG_APCC_DBOX_1

Location: 151:159

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9178

ASA_SCORE: 77.0111

COIL: 0.5298

CONS_SCORE: 0.3946

DSS_SCORE: 0.3529

HELIX: 0.4299

FCONS_SCORE: 1.0936

RIG_SCORE: 0.7995

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G166C	TCGA-55-7994	LUAD	TCGA	ERELLSLVS	DEG_APCC_DBOX_1	0.1389
p.G166C	DO45311	LUAD	ICGC	ERELLSLVS	DEG_APCC_DBOX_1	0.1389
p.A161V	TCGA-79-5596	LUSC	TCGA	ERELLSLVS	DEG_APCC_DBOX_1	0.2778
p.A161V	DO27357	LUSC	ICGC	ERELLSLVS	DEG_APCC_DBOX_1	0.2778
p.G146V	TCGA-AA-A03J	COAD	TCGA	ERELLSLVS	DEG_APCC_DBOX_1	0.1944
p.G146V	DO10467	COAD	ICGC	ERELLSLVS	DEG_APCC_DBOX_1	0.1944
p.R152Q	TCGA-AB-2828	LAML	TCGA	ERELLSLVS	DEG_APCC_DBOX_1	0.7329
p.R152Q	DO21571	LAML	ICGC	ERELLSLVS	DEG_APCC_DBOX_1	0.7329
p.P160L	TCGA-B5-A3FA	UCEC	TCGA	ERELLSLVS	DEG_APCC_DBOX_1	0.3056
p.P160L	DO52402	UCEC	ICGC	ERELLSLVS	DEG_APCC_DBOX_1	0.3056
p.S159N	TCGA-CQ-7072	HNSC	TCGA	ERELLSLVS	DEG_APCC_DBOX_1	0.5958
p.S159N	DO52052	HNSC	ICGC	ERELLSLVS	DEG_APCC_DBOX_1	0.5958
p.E149K	TCGA-EE-A2MJ	SKCM	TCGA	ERELLSLVS	DEG_APCC_DBOX_1	0.2778
p.E149K	DO38099	SKCM	ICGC	ERELLSLVS	DEG_APCC_DBOX_1	0.2778
p.Q141K	TCGA-FU-A40J	CESC	TCGA	ERELLSLVS	DEG_APCC_DBOX_1	0.0556
p.Q141K	DO44314	CESC	ICGC	ERELLSLVS	DEG_APCC_DBOX_1	0.0556
p.S168R	TCGA-VQ-AA6J	STAD	TCGA	ERELLSLVS	DEG_APCC_DBOX_1	0.0833
p.S168R	DO233692	GACA	ICGC	ERELLSLVS	DEG_APCC_DBOX_1	0.0833
p.S168R	DO51802	STAD	ICGC	ERELLSLVS	DEG_APCC_DBOX_1	0.0833
p.R152W	DO52668	MALY	ICGC	ERELLSLVS	DEG_APCC_DBOX_1	0.8634
p.G146E	DO222638	MELA	ICGC	ERELLSLVS	DEG_APCC_DBOX_1	0.1944
p.C144S	DO224633	PACA	ICGC	ERELLSLVS	DEG_APCC_DBOX_1	0.1389
p.G166D	DO229264	THCA	ICGC	ERELLSLVS	DEG_APCC_DBOX_1	0.1389
p.L154M	ACH-000774	Lung Cancer	CCLE	ERELLSLVS	DEG_APCC_DBOX_1	0.5999

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TE12	LIM homeobox transcription factor 1-alpha	DEG_APCC_DBOX_1	151:159	ERELLSLVS	APC,CDC20,FZR1	0.9178	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons