DegronMD - Q8TE12(LMX1A)

FUNCTION: Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae (By similarity). {ECO:0000250}.

GO - Biological processes (BP): axon guidance [GO:0007411]; central nervous system neuron differentiation [GO:0021953]; cerebellum development [GO:0021549]; dentate gyrus development [GO:0021542]; dopaminergic neuron differentiation [GO:0071542]; locomotory behavior [GO:0007626]; memory [GO:0007613]; midbrain dopaminergic neuron d... View more >>

GO - Molecular function (MF): DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; seq... View more >>

GO - Cellular component (CC): chromatin [GO:0000785]; nucleus [GO:0005634]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R152W	DO52668	MALY	ICGC	ERELLSLVS	DEG_APCC_DBOX_1	151:159	Mutation altering degron motif	0.8634
p.Y290F	TCGA-44-5644	LUAD	TCGA	NPYTALP	CBL_PTK	288:294	Mutation altering degron motif	0.7528
p.Y290F	DO25153	LUAD	ICGC	NPYTALP	CBL_PTK	288:294	Mutation altering degron motif	0.7528
p.R152Q	TCGA-AB-2828	LAML	TCGA	ERELLSLVS	DEG_APCC_DBOX_1	151:159	Mutation altering degron motif	0.7329
p.R152Q	DO21571	LAML	ICGC	ERELLSLVS	DEG_APCC_DBOX_1	151:159	Mutation altering degron motif	0.7329
p.T291K	DO229031	LICA	ICGC	NPYTALP	CBL_PTK	288:294	Mutation altering degron motif	0.7306
p.A292S	TCGA-95-7562	LUAD	TCGA	NPYTALP	CBL_PTK	288:294	Mutation altering degron motif	0.6477
p.A292S	DO51196	LUAD	ICGC	NPYTALP	CBL_PTK	288:294	Mutation altering degron motif	0.6477
p.P289L	DO222420	MELA	ICGC	NPYTALP	CBL_PTK	288:294	Mutation altering degron motif	0.6471
p.L154M	ACH-000774	Lung Cancer	CCLE	ERELLSLVS	DEG_APCC_DBOX_1	151:159	Mutation altering degron motif	0.5999
p.S159N	TCGA-CQ-7072	HNSC	TCGA	ERELLSLVS	DEG_APCC_DBOX_1	151:159	Mutation altering degron motif	0.5958
p.S159N	DO52052	HNSC	ICGC	ERELLSLVS	DEG_APCC_DBOX_1	151:159	Mutation altering degron motif	0.5958
p.N288D	TCGA-AA-3667	COAD	TCGA	NPYTALP	CBL_PTK	288:294	Mutation altering degron motif	0.5821
p.N288D	DO7997	COAD	ICGC	NPYTALP	CBL_PTK	288:294	Mutation altering degron motif	0.5821
p.P160L	TCGA-B5-A3FA	UCEC	TCGA	ERELLSLVS	DEG_APCC_DBOX_1	151:159	Mutation rewiring degron network	0.3056
p.P160L	DO52402	UCEC	ICGC	ERELLSLVS	DEG_APCC_DBOX_1	151:159	Mutation rewiring degron network	0.3056
p.M287I	TCGA-D1-A16X	UCEC	TCGA	NPYTALP	CBL_PTK	288:294	Mutation rewiring degron network	0.3056
p.M287I	DO222363	MELA	ICGC	NPYTALP	CBL_PTK	288:294	Mutation rewiring degron network	0.3056
p.M287I	DO41799	UCEC	ICGC	NPYTALP	CBL_PTK	288:294	Mutation rewiring degron network	0.3056
p.T295N	DO229009	LICA	ICGC	NPYTALP	CBL_PTK	288:294	Mutation rewiring degron network	0.3056

Showing 1 to 20 of 51 entries

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Kaplan plot for LMX1A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LMX1A

UniProt ID: Q8TE12

Entrez ID: 4009

Protein name: LIM homeobox transcription factor 1-alpha (LIM/homeobox protein 1.1) (LMX-1.1) (LIM/homeobox protein LMX1A)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LMX1A in