DegronMD - Q8TE12(LMX1A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q297L	TCGA-44-5644	LUAD	TCGA	NPYTALP	CBL_PTK	288:294	Mutation rewiring degron network	0.25
p.Q297L	DO25153	LUAD	ICGC	NPYTALP	CBL_PTK	288:294	Mutation rewiring degron network	0.25
p.Y290F	TCGA-44-5644	LUAD	TCGA	NPYTALP	CBL_PTK	288:294	Mutation altering degron motif	0.7528
p.Y290F	DO25153	LUAD	ICGC	NPYTALP	CBL_PTK	288:294	Mutation altering degron motif	0.7528
p.G166C	TCGA-55-7994	LUAD	TCGA	ERELLSLVS	DEG_APCC_DBOX_1	151:159	Mutation rewiring degron network	0.1389
p.G166C	DO45311	LUAD	ICGC	ERELLSLVS	DEG_APCC_DBOX_1	151:159	Mutation rewiring degron network	0.1389
p.A161V	TCGA-79-5596	LUSC	TCGA	ERELLSLVS	DEG_APCC_DBOX_1	151:159	Mutation rewiring degron network	0.2778
p.A161V	DO27357	LUSC	ICGC	ERELLSLVS	DEG_APCC_DBOX_1	151:159	Mutation rewiring degron network	0.2778
p.A292S	TCGA-95-7562	LUAD	TCGA	NPYTALP	CBL_PTK	288:294	Mutation altering degron motif	0.6477
p.A292S	DO51196	LUAD	ICGC	NPYTALP	CBL_PTK	288:294	Mutation altering degron motif	0.6477
p.N288D	TCGA-AA-3667	COAD	TCGA	NPYTALP	CBL_PTK	288:294	Mutation altering degron motif	0.5821
p.N288D	DO7997	COAD	ICGC	NPYTALP	CBL_PTK	288:294	Mutation altering degron motif	0.5821
p.G146V	TCGA-AA-A03J	COAD	TCGA	ERELLSLVS	DEG_APCC_DBOX_1	151:159	Mutation rewiring degron network	0.1944
p.G146V	DO10467	COAD	ICGC	ERELLSLVS	DEG_APCC_DBOX_1	151:159	Mutation rewiring degron network	0.1944
p.R152Q	TCGA-AB-2828	LAML	TCGA	ERELLSLVS	DEG_APCC_DBOX_1	151:159	Mutation altering degron motif	0.7329
p.R152Q	DO21571	LAML	ICGC	ERELLSLVS	DEG_APCC_DBOX_1	151:159	Mutation altering degron motif	0.7329
p.P160L	TCGA-B5-A3FA	UCEC	TCGA	ERELLSLVS	DEG_APCC_DBOX_1	151:159	Mutation rewiring degron network	0.3056
p.P160L	DO52402	UCEC	ICGC	ERELLSLVS	DEG_APCC_DBOX_1	151:159	Mutation rewiring degron network	0.3056
p.P296S	TCGA-B7-5816	STAD	TCGA	NPYTALP	CBL_PTK	288:294	Mutation rewiring degron network	0.2778
p.P296S	DO38599	STAD	ICGC	NPYTALP	CBL_PTK	288:294	Mutation rewiring degron network	0.2778
p.M283I	TCGA-BF-AAP1	SKCM	TCGA	NPYTALP	CBL_PTK	288:294	Mutation rewiring degron network	0.1944
p.M283I	DO219464	SKCM	ICGC	NPYTALP	CBL_PTK	288:294	Mutation rewiring degron network	0.1944
p.S159N	TCGA-CQ-7072	HNSC	TCGA	ERELLSLVS	DEG_APCC_DBOX_1	151:159	Mutation altering degron motif	0.5958
p.S159N	DO52052	HNSC	ICGC	ERELLSLVS	DEG_APCC_DBOX_1	151:159	Mutation altering degron motif	0.5958
p.M287I	TCGA-D1-A16X	UCEC	TCGA	NPYTALP	CBL_PTK	288:294	Mutation rewiring degron network	0.3056
p.M287I	DO222363	MELA	ICGC	NPYTALP	CBL_PTK	288:294	Mutation rewiring degron network	0.3056
p.M287I	DO41799	UCEC	ICGC	NPYTALP	CBL_PTK	288:294	Mutation rewiring degron network	0.3056
p.G282E	TCGA-EE-A2GP	SKCM	TCGA	NPYTALP	CBL_PTK	288:294	Mutation rewiring degron network	0.1667
p.G282E	DO37422	SKCM	ICGC	NPYTALP	CBL_PTK	288:294	Mutation rewiring degron network	0.1667
p.E149K	TCGA-EE-A2MJ	SKCM	TCGA	ERELLSLVS	DEG_APCC_DBOX_1	151:159	Mutation rewiring degron network	0.2778
p.E149K	DO38099	SKCM	ICGC	ERELLSLVS	DEG_APCC_DBOX_1	151:159	Mutation rewiring degron network	0.2778
p.G279V	TCGA-FS-A1ZG	SKCM	TCGA	NPYTALP	CBL_PTK	288:294	Mutation rewiring degron network	0.0833
p.G279V	DO37523	SKCM	ICGC	NPYTALP	CBL_PTK	288:294	Mutation rewiring degron network	0.0833
p.Q141K	TCGA-FU-A40J	CESC	TCGA	ERELLSLVS	DEG_APCC_DBOX_1	151:159	Mutation rewiring degron network	0.0556
p.Q141K	DO44314	CESC	ICGC	ERELLSLVS	DEG_APCC_DBOX_1	151:159	Mutation rewiring degron network	0.0556
p.S168R	TCGA-VQ-AA6J	STAD	TCGA	ERELLSLVS	DEG_APCC_DBOX_1	151:159	Mutation rewiring degron network	0.0833
p.S168R	DO233692	GACA	ICGC	ERELLSLVS	DEG_APCC_DBOX_1	151:159	Mutation rewiring degron network	0.0833
p.S168R	DO51802	STAD	ICGC	ERELLSLVS	DEG_APCC_DBOX_1	151:159	Mutation rewiring degron network	0.0833
p.G285V	DO10809	EOPC	ICGC	NPYTALP	CBL_PTK	288:294	Mutation rewiring degron network	0.25
p.T291K	DO229031	LICA	ICGC	NPYTALP	CBL_PTK	288:294	Mutation altering degron motif	0.7306
p.T295N	DO229009	LICA	ICGC	NPYTALP	CBL_PTK	288:294	Mutation rewiring degron network	0.3056
p.G278C	DO231141	LUSC	ICGC	NPYTALP	CBL_PTK	288:294	Mutation rewiring degron network	0.0556
p.R152W	DO52668	MALY	ICGC	ERELLSLVS	DEG_APCC_DBOX_1	151:159	Mutation altering degron motif	0.8634
p.P289L	DO222420	MELA	ICGC	NPYTALP	CBL_PTK	288:294	Mutation altering degron motif	0.6471
p.G146E	DO222638	MELA	ICGC	ERELLSLVS	DEG_APCC_DBOX_1	151:159	Mutation rewiring degron network	0.1944
p.C144S	DO224633	PACA	ICGC	ERELLSLVS	DEG_APCC_DBOX_1	151:159	Mutation rewiring degron network	0.1389
p.G166D	DO229264	THCA	ICGC	ERELLSLVS	DEG_APCC_DBOX_1	151:159	Mutation rewiring degron network	0.1389
p.L300M	SIDM01265	Plasma Cell Myeloma	GDSC	NPYTALP	CBL_PTK	288:294	Mutation rewiring degron network	0.1667
p.L300M	ACH-000763	Myeloma	CCLE	NPYTALP	CBL_PTK	288:294	Mutation rewiring degron network	0.1667
p.L300M	MM1S	haematopoietic and lymphoid tissue	COSMIC	NPYTALP	CBL_PTK	288:294	Mutation rewiring degron network	0.1667
p.L154M	ACH-000774	Lung Cancer	CCLE	ERELLSLVS	DEG_APCC_DBOX_1	151:159	Mutation altering degron motif	0.5999

Kaplan plot for LMX1A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LMX1A

UniProt ID: Q8TE12

Entrez ID: 4009

Protein name: LIM homeobox transcription factor 1-alpha (LIM/homeobox protein 1.1) (LMX-1.1) (LIM/homeobox protein LMX1A)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LMX1A in