DegronMD

Uniprot ID: Q8TE12

Source protein: LIM homeobox transcription factor 1-alpha

Source gene: LMX1A

Class: CBL_PTK

Location: 288:294

E3 ligase: CBL

DEGRON score: 0.971

ASA_SCORE: 77.5143

COIL: 0.9021

CONS_SCORE: 0.4211

DSS_SCORE: 0.5237

HELIX: 0.0387

FCONS_SCORE: 1.0077

RIG_SCORE: 0.7608

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q297L	TCGA-44-5644	LUAD	TCGA	NPYTALP	CBL_PTK	0.25
p.Q297L	DO25153	LUAD	ICGC	NPYTALP	CBL_PTK	0.25
p.Y290F	TCGA-44-5644	LUAD	TCGA	NPYTALP	CBL_PTK	0.7528
p.Y290F	DO25153	LUAD	ICGC	NPYTALP	CBL_PTK	0.7528
p.A292S	TCGA-95-7562	LUAD	TCGA	NPYTALP	CBL_PTK	0.6477
p.A292S	DO51196	LUAD	ICGC	NPYTALP	CBL_PTK	0.6477
p.N288D	TCGA-AA-3667	COAD	TCGA	NPYTALP	CBL_PTK	0.5821
p.N288D	DO7997	COAD	ICGC	NPYTALP	CBL_PTK	0.5821
p.P296S	TCGA-B7-5816	STAD	TCGA	NPYTALP	CBL_PTK	0.2778
p.P296S	DO38599	STAD	ICGC	NPYTALP	CBL_PTK	0.2778
p.M283I	TCGA-BF-AAP1	SKCM	TCGA	NPYTALP	CBL_PTK	0.1944
p.M283I	DO219464	SKCM	ICGC	NPYTALP	CBL_PTK	0.1944
p.M287I	TCGA-D1-A16X	UCEC	TCGA	NPYTALP	CBL_PTK	0.3056
p.M287I	DO222363	MELA	ICGC	NPYTALP	CBL_PTK	0.3056
p.M287I	DO41799	UCEC	ICGC	NPYTALP	CBL_PTK	0.3056
p.G282E	TCGA-EE-A2GP	SKCM	TCGA	NPYTALP	CBL_PTK	0.1667
p.G282E	DO37422	SKCM	ICGC	NPYTALP	CBL_PTK	0.1667
p.G279V	TCGA-FS-A1ZG	SKCM	TCGA	NPYTALP	CBL_PTK	0.0833
p.G279V	DO37523	SKCM	ICGC	NPYTALP	CBL_PTK	0.0833
p.G285V	DO10809	EOPC	ICGC	NPYTALP	CBL_PTK	0.25
p.T291K	DO229031	LICA	ICGC	NPYTALP	CBL_PTK	0.7306
p.T295N	DO229009	LICA	ICGC	NPYTALP	CBL_PTK	0.3056
p.G278C	DO231141	LUSC	ICGC	NPYTALP	CBL_PTK	0.0556
p.P289L	DO222420	MELA	ICGC	NPYTALP	CBL_PTK	0.6471
p.L300M	SIDM01265	Plasma Cell Myeloma	GDSC	NPYTALP	CBL_PTK	0.1667
p.L300M	ACH-000763	Myeloma	CCLE	NPYTALP	CBL_PTK	0.1667
p.L300M	MM1S	haematopoietic_and_lymphoid_tissue	COSMIC	NPYTALP	CBL_PTK	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TE12	LIM homeobox transcription factor 1-alpha	CBL_PTK	288:294	NPYTALP	CBL	0.971	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons