DegronMD

Uniprot ID: P20849

Source protein: Collagen alpha-1

Source gene: COL9A1

Class: DEG_APCC_DBOX_1

Location: 689:697

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9828

ASA_SCORE: 80.7556

COIL: 0.932

CONS_SCORE: 0.6895

DSS_SCORE: 0.7937

HELIX: 0.0158

FCONS_SCORE: 1.0316

RIG_SCORE: 0.6268

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G700D	TCGA-05-4382	LUAD	TCGA	ERGELGDIG	DEG_APCC_DBOX_1	0.25
p.I696K	TCGA-A7-A26H	BRCA	TCGA	ERGELGDIG	DEG_APCC_DBOX_1	0.7531
p.S681F	TCGA-D3-A8GL	SKCM	TCGA	ERGELGDIG	DEG_APCC_DBOX_1	0.1111
p.G697E	TCGA-EB-A6QY	SKCM	TCGA	ERGELGDIG	DEG_APCC_DBOX_1	0.6087
p.D695N	TCGA-EE-A3AA	SKCM	TCGA	ERGELGDIG	DEG_APCC_DBOX_1	0.5821
p.A680T	TCGA-EI-6507	READ	TCGA	ERGELGDIG	DEG_APCC_DBOX_1	0.0833
p.K702Q	TCGA-F5-6814	READ	TCGA	ERGELGDIG	DEG_APCC_DBOX_1	0.3056
p.S704C	TCGA-NK-A5CT	LUSC	TCGA	ERGELGDIG	DEG_APCC_DBOX_1	0.1389
p.E692K	TCGA-QQ-A5VD	SARC	TCGA	ERGELGDIG	DEG_APCC_DBOX_1	0.591
p.E692K	SIDM00653	Small Cell Lung Carcinoma	GDSC	ERGELGDIG	DEG_APCC_DBOX_1	0.591
p.E692K	ACH-000514	Lung Cancer	CCLE	ERGELGDIG	DEG_APCC_DBOX_1	0.591
p.E692K	NCI-H1092	lung	COSMIC	ERGELGDIG	DEG_APCC_DBOX_1	0.591
p.E684D	TCGA-VQ-AA6D	STAD	TCGA	ERGELGDIG	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20849	Collagen alpha-1	DEG_APCC_DBOX_1	689:697	ERGELGDIG	APC,CDC20,FZR1	0.9828	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons