DegronMD - P20849(COL9A1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G700D	TCGA-05-4382	LUAD	TCGA	ERGELGDIG	DEG_APCC_DBOX_1	689:697	Mutation rewiring degron network	0.25
p.H253N	TCGA-55-7727	LUAD	TCGA	ITPSQT	DEG_SCF_FBW7_1	259:264	Mutation rewiring degron network	0.1667
p.H253N	DO24297	LUAD	ICGC	ITPSQT	DEG_SCF_FBW7_1	259:264	Mutation rewiring degron network	0.1667
p.I696K	TCGA-A7-A26H	BRCA	TCGA	ERGELGDIG	DEG_APCC_DBOX_1	689:697	Mutation altering degron motif	0.7531
p.E629V	TCGA-CR-7364	HNSC	TCGA	SRGELGPVG	DEG_APCC_DBOX_1	626:634	Mutation altering degron motif	0.6582
p.E267D	TCGA-CV-7101	HNSC	TCGA	ITPSQT	DEG_SCF_FBW7_1	259:264	Mutation rewiring degron network	0.25
p.E267D	DO15310	HNSC	ICGC	ITPSQT	DEG_SCF_FBW7_1	259:264	Mutation rewiring degron network	0.25
p.T251I	TCGA-CV-7433	HNSC	TCGA	ITPSQT	DEG_SCF_FBW7_1	259:264	Mutation rewiring degron network	0.1111
p.T251I	DO15038	HNSC	ICGC	ITPSQT	DEG_SCF_FBW7_1	259:264	Mutation rewiring degron network	0.1111
p.S681F	TCGA-D3-A8GL	SKCM	TCGA	ERGELGDIG	DEG_APCC_DBOX_1	689:697	Mutation rewiring degron network	0.1111
p.G697E	TCGA-EB-A6QY	SKCM	TCGA	ERGELGDIG	DEG_APCC_DBOX_1	689:697	Mutation altering degron motif	0.6087
p.P261H	TCGA-EE-A181	SKCM	TCGA	ITPSQT	DEG_SCF_FBW7_1	259:264	Mutation altering degron motif	0.7694
p.P261H	DO229035	LICA	ICGC	ITPSQT	DEG_SCF_FBW7_1	259:264	Mutation altering degron motif	0.7694
p.P261H	DO37444	SKCM	ICGC	ITPSQT	DEG_SCF_FBW7_1	259:264	Mutation altering degron motif	0.7694
p.D695N	TCGA-EE-A3AA	SKCM	TCGA	ERGELGDIG	DEG_APCC_DBOX_1	689:697	Mutation altering degron motif	0.5821
p.R249I	TCGA-EE-A3AA	SKCM	TCGA	ITPSQT	DEG_SCF_FBW7_1	259:264	Mutation rewiring degron network	0.0556
p.R249I	DO37571	SKCM	ICGC	ITPSQT	DEG_SCF_FBW7_1	259:264	Mutation rewiring degron network	0.0556
p.A680T	TCGA-EI-6507	READ	TCGA	ERGELGDIG	DEG_APCC_DBOX_1	689:697	Mutation rewiring degron network	0.0833
p.R618Q	TCGA-EY-A1GD	UCEC	TCGA	SRGELGPVG	DEG_APCC_DBOX_1	626:634	Mutation rewiring degron network	0.1111
p.R618Q	ACH-001568	Skin Cancer	CCLE	SRGELGPVG	DEG_APCC_DBOX_1	626:634	Mutation rewiring degron network	0.1111
p.K702Q	TCGA-F5-6814	READ	TCGA	ERGELGDIG	DEG_APCC_DBOX_1	689:697	Mutation substituting flanking lysine	0.3056
p.P624S	TCGA-FS-A4F5	SKCM	TCGA	SRGELGPVG	DEG_APCC_DBOX_1	626:634	Mutation rewiring degron network	0.2778
p.P624S	TCGA-FW-A3R5	SKCM	TCGA	SRGELGPVG	DEG_APCC_DBOX_1	626:634	Mutation rewiring degron network	0.2778
p.S704C	TCGA-NK-A5CT	LUSC	TCGA	ERGELGDIG	DEG_APCC_DBOX_1	689:697	Mutation rewiring degron network	0.1389
p.E692K	TCGA-QQ-A5VD	SARC	TCGA	ERGELGDIG	DEG_APCC_DBOX_1	689:697	Mutation altering degron motif	0.591
p.E692K	SIDM00653	Small Cell Lung Carcinoma	GDSC	ERGELGDIG	DEG_APCC_DBOX_1	689:697	Mutation altering degron motif	0.591
p.E692K	ACH-000514	Lung Cancer	CCLE	ERGELGDIG	DEG_APCC_DBOX_1	689:697	Mutation altering degron motif	0.591
p.E692K	NCI-H1092	lung	COSMIC	ERGELGDIG	DEG_APCC_DBOX_1	689:697	Mutation altering degron motif	0.591
p.L623R	TCGA-RD-A7BT	STAD	TCGA	SRGELGPVG	DEG_APCC_DBOX_1	626:634	Mutation rewiring degron network	0.25
p.S635T	TCGA-T3-A92M	HNSC	TCGA	SRGELGPVG	DEG_APCC_DBOX_1	626:634	Mutation rewiring degron network	0.3056
p.E684D	TCGA-VQ-AA6D	STAD	TCGA	ERGELGDIG	DEG_APCC_DBOX_1	689:697	Mutation rewiring degron network	0.1944
p.G253S	DO223732	CESC	ICGC	ITPSQT	DEG_SCF_FBW7_1	259:264	Mutation rewiring degron network	0.1667
p.G629D	DO7801	COAD	ICGC	SRGELGPVG	DEG_APCC_DBOX_1	626:634	Mutation altering degron motif	0.7198
p.T264I	DO11854	GBM	ICGC	ITPSQT	DEG_SCF_FBW7_1	259:264	Mutation altering degron motif	0.7078
p.T264I	DO50955	LICA	ICGC	ITPSQT	DEG_SCF_FBW7_1	259:264	Mutation altering degron motif	0.7078
p.T260K	DO229019	LICA	ICGC	ITPSQT	DEG_SCF_FBW7_1	259:264	Mutation altering degron motif	0.7306
p.Q274K	DO229037	LICA	ICGC	ITPSQT	DEG_SCF_FBW7_1	259:264	Mutation rewiring degron network	0.0556
p.E254D	DO231797	LINC	ICGC	ITPSQT	DEG_SCF_FBW7_1	259:264	Mutation rewiring degron network	0.1944
p.G253R	DO45051	LINC	ICGC	ITPSQT	DEG_SCF_FBW7_1	259:264	Mutation rewiring degron network	0.1667
p.D619A	DO24665	LUAD	ICGC	SRGELGPVG	DEG_APCC_DBOX_1	626:634	Mutation rewiring degron network	0.1389
p.P636L	DO220875	MELA	ICGC	SRGELGPVG	DEG_APCC_DBOX_1	626:634	Mutation rewiring degron network	0.2778
p.P255S	DO220886	MELA	ICGC	ITPSQT	DEG_SCF_FBW7_1	259:264	Mutation rewiring degron network	0.2222
p.P255S	DO38069	SKCM	ICGC	ITPSQT	DEG_SCF_FBW7_1	259:264	Mutation rewiring degron network	0.2222
p.P255S	DO38063	SKCM	ICGC	ITPSQT	DEG_SCF_FBW7_1	259:264	Mutation rewiring degron network	0.2222
p.P255S	KYSE-180	oesophagus	COSMIC	ITPSQT	DEG_SCF_FBW7_1	259:264	Mutation rewiring degron network	0.2222
p.P255S	LOXIMVI	skin	COSMIC	ITPSQT	DEG_SCF_FBW7_1	259:264	Mutation rewiring degron network	0.2222
p.G641E	DO222775	MELA	ICGC	SRGELGPVG	DEG_APCC_DBOX_1	626:634	Mutation substituting flanking lysine	0.25
p.G641E	DO47665	SKCM	ICGC	SRGELGPVG	DEG_APCC_DBOX_1	626:634	Mutation substituting flanking lysine	0.25
p.T260A	DO222702	MELA	ICGC	ITPSQT	DEG_SCF_FBW7_1	259:264	Mutation altering degron motif	0.7139
p.G638E	DO222708	MELA	ICGC	SRGELGPVG	DEG_APCC_DBOX_1	626:634	Mutation rewiring degron network	0.2222
p.G265E	DO222875	MELA	ICGC	ITPSQT	DEG_SCF_FBW7_1	259:264	Mutation rewiring degron network	0.3056
p.D260N	DO50300	SKCM	ICGC	ITPSQT	DEG_SCF_FBW7_1	259:264	Mutation altering degron motif	0.6932
p.P643S	DO50298	SKCM	ICGC	SRGELGPVG	DEG_APCC_DBOX_1	626:634	Mutation rewiring degron network	0.0833
p.P643S	DO38099	SKCM	ICGC	SRGELGPVG	DEG_APCC_DBOX_1	626:634	Mutation rewiring degron network	0.0833
p.P272T	DO229259	THCA	ICGC	ITPSQT	DEG_SCF_FBW7_1	259:264	Mutation rewiring degron network	0.1111
p.G644V	DO42793	UCEC	ICGC	SRGELGPVG	DEG_APCC_DBOX_1	626:634	Mutation rewiring degron network	0.0556
p.P271L	SIDM00625	Other Sarcomas	GDSC	ITPSQT	DEG_SCF_FBW7_1	259:264	Mutation rewiring degron network	0.1389
p.P271L	ACH-000449	Sarcoma	CCLE	ITPSQT	DEG_SCF_FBW7_1	259:264	Mutation rewiring degron network	0.1389
p.P271L	MES-SA	soft tissue	COSMIC	ITPSQT	DEG_SCF_FBW7_1	259:264	Mutation rewiring degron network	0.1389
p.S635F	SIDM00562	Breast Carcinoma	GDSC	SRGELGPVG	DEG_APCC_DBOX_1	626:634	Mutation rewiring degron network	0.3056
p.S635F	ACH-002163	Breast Cancer	CCLE	SRGELGPVG	DEG_APCC_DBOX_1	626:634	Mutation rewiring degron network	0.3056
p.S635F	MRK-nu-1	breast	COSMIC	SRGELGPVG	DEG_APCC_DBOX_1	626:634	Mutation rewiring degron network	0.3056
p.G619R	ACH-001568	Skin Cancer	CCLE	SRGELGPVG	DEG_APCC_DBOX_1	626:634	Mutation rewiring degron network	0.1389
p.G268A	SLVL	haematopoietic and lymphoid tissue	COSMIC	ITPSQT	DEG_SCF_FBW7_1	259:264	Mutation rewiring degron network	0.2222
p.P251T	COR-L32	lung	COSMIC	ITPSQT	DEG_SCF_FBW7_1	259:264	Mutation rewiring degron network	0.1111
p.G632S	RS4-11	haematopoietic and lymphoid tissue	COSMIC	SRGELGPVG	DEG_APCC_DBOX_1	626:634	Mutation altering degron motif	0.6993

DegronMD: protein-targeted degradation, mutation and drug response to degrons

COL9A1

UniProt ID: P20849

Entrez ID: 1297

Protein name: Collagen alpha-1(IX) chain

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for COL9A1 in