DegronMD

Uniprot ID: P20849

Source protein: Collagen alpha-1

Source gene: COL9A1

Class: DEG_SCF_FBW7_1

Location: 259:264

E3 ligase: FBXW7

DEGRON score: 0.8372

ASA_SCORE: 82.3

COIL: 0.9598

CONS_SCORE: 0.3582

DSS_SCORE: 0.7976

HELIX: 0.01

FCONS_SCORE: 0.6878

RIG_SCORE: 0.6108

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H253N	TCGA-55-7727	LUAD	TCGA	ITPSQT	DEG_SCF_FBW7_1	0.1667
p.H253N	DO24297	LUAD	ICGC	ITPSQT	DEG_SCF_FBW7_1	0.1667
p.E267D	TCGA-CV-7101	HNSC	TCGA	ITPSQT	DEG_SCF_FBW7_1	0.25
p.E267D	DO15310	HNSC	ICGC	ITPSQT	DEG_SCF_FBW7_1	0.25
p.T251I	TCGA-CV-7433	HNSC	TCGA	ITPSQT	DEG_SCF_FBW7_1	0.1111
p.T251I	DO15038	HNSC	ICGC	ITPSQT	DEG_SCF_FBW7_1	0.1111
p.P261H	TCGA-EE-A181	SKCM	TCGA	ITPSQT	DEG_SCF_FBW7_1	0.7694
p.P261H	DO229035	LICA	ICGC	ITPSQT	DEG_SCF_FBW7_1	0.7694
p.P261H	DO37444	SKCM	ICGC	ITPSQT	DEG_SCF_FBW7_1	0.7694
p.R249I	TCGA-EE-A3AA	SKCM	TCGA	ITPSQT	DEG_SCF_FBW7_1	0.0556
p.R249I	DO37571	SKCM	ICGC	ITPSQT	DEG_SCF_FBW7_1	0.0556
p.G253S	DO223732	CESC	ICGC	ITPSQT	DEG_SCF_FBW7_1	0.1667
p.T264I	DO11854	GBM	ICGC	ITPSQT	DEG_SCF_FBW7_1	0.7078
p.T264I	DO50955	LICA	ICGC	ITPSQT	DEG_SCF_FBW7_1	0.7078
p.T260K	DO229019	LICA	ICGC	ITPSQT	DEG_SCF_FBW7_1	0.7306
p.Q274K	DO229037	LICA	ICGC	ITPSQT	DEG_SCF_FBW7_1	0.0556
p.E254D	DO231797	LINC	ICGC	ITPSQT	DEG_SCF_FBW7_1	0.1944
p.G253R	DO45051	LINC	ICGC	ITPSQT	DEG_SCF_FBW7_1	0.1667
p.P255S	DO220886	MELA	ICGC	ITPSQT	DEG_SCF_FBW7_1	0.2222
p.P255S	DO38069	SKCM	ICGC	ITPSQT	DEG_SCF_FBW7_1	0.2222
p.P255S	DO38063	SKCM	ICGC	ITPSQT	DEG_SCF_FBW7_1	0.2222
p.P255S	KYSE-180	oesophagus	COSMIC	ITPSQT	DEG_SCF_FBW7_1	0.2222
p.P255S	LOXIMVI	skin	COSMIC	ITPSQT	DEG_SCF_FBW7_1	0.2222
p.T260A	DO222702	MELA	ICGC	ITPSQT	DEG_SCF_FBW7_1	0.7139
p.G265E	DO222875	MELA	ICGC	ITPSQT	DEG_SCF_FBW7_1	0.3056
p.D260N	DO50300	SKCM	ICGC	ITPSQT	DEG_SCF_FBW7_1	0.6932
p.P272T	DO229259	THCA	ICGC	ITPSQT	DEG_SCF_FBW7_1	0.1111
p.P271L	SIDM00625	Other Sarcomas	GDSC	ITPSQT	DEG_SCF_FBW7_1	0.1389
p.P271L	ACH-000449	Sarcoma	CCLE	ITPSQT	DEG_SCF_FBW7_1	0.1389
p.P271L	MES-SA	soft_tissue	COSMIC	ITPSQT	DEG_SCF_FBW7_1	0.1389
p.G268A	SLVL	haematopoietic_and_lymphoid_tissue	COSMIC	ITPSQT	DEG_SCF_FBW7_1	0.2222
p.P251T	COR-L32	lung	COSMIC	ITPSQT	DEG_SCF_FBW7_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ITPSQT

Degron related mutations and impact score

Drug responses associated with COL9A1 mutations

All proteins holding degron of ITPSQT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20849	Collagen alpha-1	DEG_SCF_FBW7_1	259:264	ITPSQT	FBXW7	0.8372	More...