DegronMD

Uniprot ID: P20849

Source protein: Collagen alpha-1

Source gene: COL9A1

Class: DEG_APCC_DBOX_1

Location: 626:634

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9881

ASA_SCORE: 76.3222

COIL: 0.9413

CONS_SCORE: 0.705

DSS_SCORE: 0.7771

HELIX: 0.0186

FCONS_SCORE: 1.0387

RIG_SCORE: 0.5613

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E629V	TCGA-CR-7364	HNSC	TCGA	SRGELGPVG	DEG_APCC_DBOX_1	0.6582
p.R618Q	TCGA-EY-A1GD	UCEC	TCGA	SRGELGPVG	DEG_APCC_DBOX_1	0.1111
p.R618Q	ACH-001568	Skin Cancer	CCLE	SRGELGPVG	DEG_APCC_DBOX_1	0.1111
p.P624S	TCGA-FS-A4F5	SKCM	TCGA	SRGELGPVG	DEG_APCC_DBOX_1	0.2778
p.P624S	TCGA-FW-A3R5	SKCM	TCGA	SRGELGPVG	DEG_APCC_DBOX_1	0.2778
p.L623R	TCGA-RD-A7BT	STAD	TCGA	SRGELGPVG	DEG_APCC_DBOX_1	0.25
p.S635T	TCGA-T3-A92M	HNSC	TCGA	SRGELGPVG	DEG_APCC_DBOX_1	0.3056
p.G629D	DO7801	COAD	ICGC	SRGELGPVG	DEG_APCC_DBOX_1	0.7198
p.D619A	DO24665	LUAD	ICGC	SRGELGPVG	DEG_APCC_DBOX_1	0.1389
p.P636L	DO220875	MELA	ICGC	SRGELGPVG	DEG_APCC_DBOX_1	0.2778
p.G641E	DO222775	MELA	ICGC	SRGELGPVG	DEG_APCC_DBOX_1	0.25
p.G641E	DO47665	SKCM	ICGC	SRGELGPVG	DEG_APCC_DBOX_1	0.25
p.G638E	DO222708	MELA	ICGC	SRGELGPVG	DEG_APCC_DBOX_1	0.2222
p.P643S	DO50298	SKCM	ICGC	SRGELGPVG	DEG_APCC_DBOX_1	0.0833
p.P643S	DO38099	SKCM	ICGC	SRGELGPVG	DEG_APCC_DBOX_1	0.0833
p.G644V	DO42793	UCEC	ICGC	SRGELGPVG	DEG_APCC_DBOX_1	0.0556
p.S635F	SIDM00562	Breast Carcinoma	GDSC	SRGELGPVG	DEG_APCC_DBOX_1	0.3056
p.S635F	ACH-002163	Breast Cancer	CCLE	SRGELGPVG	DEG_APCC_DBOX_1	0.3056
p.S635F	MRK-nu-1	breast	COSMIC	SRGELGPVG	DEG_APCC_DBOX_1	0.3056
p.G619R	ACH-001568	Skin Cancer	CCLE	SRGELGPVG	DEG_APCC_DBOX_1	0.1389
p.G632S	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	SRGELGPVG	DEG_APCC_DBOX_1	0.6993

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20849	Collagen alpha-1	DEG_APCC_DBOX_1	626:634	SRGELGPVG	APC,CDC20,FZR1	0.9881	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons