DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
ERGGLPVIE
Uniprot ID:
O95153
Source protein:
Peripheral-type benzodiazepine receptor-associated protein 1
Source gene:
TSPOAP1
Class:
DEG_APCC_DBOX_1
Location:
1448:1456
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9805
ASA_SCORE:
85.9889
COIL:
0.7959
CONS_SCORE:
0.4235
DSS_SCORE:
0.6781
HELIX:
0.0549
FCONS_SCORE:
1.0329
RIG_SCORE:
0.6535
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G1466R
SIDM01619
Endometrial Carcinoma
GDSC
ERGGLPVIE
DEG_APCC_DBOX_1
0.0556
p.I1439N
GP5d
large_intestine
COSMIC
ERGGLPVIE
DEG_APCC_DBOX_1
0.0833
Drug responses associated with TSPOAP1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ERGGLPVIE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O95153
Peripheral-type benzodiazepine receptor-associated protein 1
DEG_APCC_DBOX_1
1448:1456
ERGGLPVIE
APC,CDC20,FZR1
0.9805
More...