DegronMD

Uniprot ID: Q96PY6

Source protein: Serine/threonine-protein kinase Nek1

Source gene: NEK1

Class: DEG_APCC_DBOX_1

Location: 476:484

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5176

ASA_SCORE: 88.6222

COIL: 0.8818

CONS_SCORE: 0.2281

DSS_SCORE: 0.4218

HELIX: 0.0474

FCONS_SCORE: 0.7315

RIG_SCORE: 0.6869

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R484H	TCGA-13-0890	OV	TCGA	ERGILPGVR	DEG_APCC_DBOX_1	0.7133
p.R484H	TCGA-TM-A84M	LGG	TCGA	ERGILPGVR	DEG_APCC_DBOX_1	0.7133
p.R484H	DO50238	LGG	ICGC	ERGILPGVR	DEG_APCC_DBOX_1	0.7133
p.R484H	DO28273	OV	ICGC	ERGILPGVR	DEG_APCC_DBOX_1	0.7133
p.L480M	TCGA-B5-A0JY	UCEC	TCGA	ERGILPGVR	DEG_APCC_DBOX_1	0.711
p.L480M	DO43041	UCEC	ICGC	ERGILPGVR	DEG_APCC_DBOX_1	0.711
p.A492T	TCGA-BK-A13B	UCEC	TCGA	ERGILPGVR	DEG_APCC_DBOX_1	0.1111
p.A492T	DO40825	UCEC	ICGC	ERGILPGVR	DEG_APCC_DBOX_1	0.1111
p.G490E	TCGA-P5-A77X	LGG	TCGA	ERGILPGVR	DEG_APCC_DBOX_1	0.1667
p.G490E	DO218769	GACA	ICGC	ERGILPGVR	DEG_APCC_DBOX_1	0.1667
p.G490E	DO223681	LGG	ICGC	ERGILPGVR	DEG_APCC_DBOX_1	0.1667
p.E483K	DO233944	GACA	ICGC	ERGILPGVR	DEG_APCC_DBOX_1	0.7022
p.E483K	DO43987	UCEC	ICGC	ERGILPGVR	DEG_APCC_DBOX_1	0.7022
p.A491D	DO229009	LICA	ICGC	ERGILPGVR	DEG_APCC_DBOX_1	0.1389
p.K472Q	DO41235	UCEC	ICGC	ERGILPGVR	DEG_APCC_DBOX_1	0.2222
p.R484C	SIDM00267	Biliary Tract Carcinoma	GDSC	ERGILPGVR	DEG_APCC_DBOX_1	0.719
p.R484C	ACH-002312	Gallbladder Cancer	CCLE	ERGILPGVR	DEG_APCC_DBOX_1	0.719
p.R484C	TGBC24TKB	biliary_tract	COSMIC	ERGILPGVR	DEG_APCC_DBOX_1	0.719
p.Y470H	ACH-001206	Bone Cancer	CCLE	ERGILPGVR	DEG_APCC_DBOX_1	0.6111
p.R473Q	SNU-175	large_intestine	COSMIC	ERGILPGVR	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96PY6	Serine/threonine-protein kinase Nek1	DEG_APCC_DBOX_1	476:484	ERGILPGVR	APC,CDC20,FZR1	0.5176	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons