DegronMD - Q96PY6(NEK1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R484H	TCGA-13-0890	OV	TCGA	ERGILPGVR	DEG_APCC_DBOX_1	476:484	Mutation altering degron motif	0.7133
p.R484H	TCGA-TM-A84M	LGG	TCGA	ERGILPGVR	DEG_APCC_DBOX_1	476:484	Mutation altering degron motif	0.7133
p.R484H	DO50238	LGG	ICGC	ERGILPGVR	DEG_APCC_DBOX_1	476:484	Mutation altering degron motif	0.7133
p.R484H	DO28273	OV	ICGC	ERGILPGVR	DEG_APCC_DBOX_1	476:484	Mutation altering degron motif	0.7133
p.L480M	TCGA-B5-A0JY	UCEC	TCGA	ERGILPGVR	DEG_APCC_DBOX_1	476:484	Mutation altering degron motif	0.711
p.L480M	DO43041	UCEC	ICGC	ERGILPGVR	DEG_APCC_DBOX_1	476:484	Mutation altering degron motif	0.711
p.A492T	TCGA-BK-A13B	UCEC	TCGA	ERGILPGVR	DEG_APCC_DBOX_1	476:484	Mutation rewiring degron network	0.1111
p.A492T	DO40825	UCEC	ICGC	ERGILPGVR	DEG_APCC_DBOX_1	476:484	Mutation rewiring degron network	0.1111
p.D753Y	TCGA-CA-6717	COAD	TCGA	INVHED	LIG_APCC_ABBA_1	738:743	Mutation rewiring degron network	0.0556
p.G490E	TCGA-P5-A77X	LGG	TCGA	ERGILPGVR	DEG_APCC_DBOX_1	476:484	Mutation rewiring degron network	0.1667
p.G490E	DO218769	GACA	ICGC	ERGILPGVR	DEG_APCC_DBOX_1	476:484	Mutation rewiring degron network	0.1667
p.G490E	DO223681	LGG	ICGC	ERGILPGVR	DEG_APCC_DBOX_1	476:484	Mutation rewiring degron network	0.1667
p.R742C	TCGA-YG-AA3O	SKCM	TCGA	INVHED	LIG_APCC_ABBA_1	738:743	Mutation altering degron motif	0.8301
p.R741C	DO51734	COAD	ICGC	INVHED	LIG_APCC_ABBA_1	738:743	Mutation altering degron motif	0.8301
p.R741C	DO43186	UCEC	ICGC	INVHED	LIG_APCC_ABBA_1	738:743	Mutation altering degron motif	0.8301
p.E752G	DO229013	COCA	ICGC	INVHED	LIG_APCC_ABBA_1	738:743	Mutation rewiring degron network	0.0833
p.E752G	DO229003	COCA	ICGC	INVHED	LIG_APCC_ABBA_1	738:743	Mutation rewiring degron network	0.0833
p.E752G	DO229005	COCA	ICGC	INVHED	LIG_APCC_ABBA_1	738:743	Mutation rewiring degron network	0.0833
p.E752G	DO228941	LICA	ICGC	INVHED	LIG_APCC_ABBA_1	738:743	Mutation rewiring degron network	0.0833
p.E483K	DO233944	GACA	ICGC	ERGILPGVR	DEG_APCC_DBOX_1	476:484	Mutation altering degron motif	0.7022
p.E483K	DO43987	UCEC	ICGC	ERGILPGVR	DEG_APCC_DBOX_1	476:484	Mutation altering degron motif	0.7022
p.A491D	DO229009	LICA	ICGC	ERGILPGVR	DEG_APCC_DBOX_1	476:484	Mutation rewiring degron network	0.1389
p.K472Q	DO41235	UCEC	ICGC	ERGILPGVR	DEG_APCC_DBOX_1	476:484	Mutation rewiring degron network	0.2222
p.R484C	SIDM00267	Biliary Tract Carcinoma	GDSC	ERGILPGVR	DEG_APCC_DBOX_1	476:484	Mutation altering degron motif	0.719
p.R484C	ACH-002312	Gallbladder Cancer	CCLE	ERGILPGVR	DEG_APCC_DBOX_1	476:484	Mutation altering degron motif	0.719
p.R484C	TGBC24TKB	biliary tract	COSMIC	ERGILPGVR	DEG_APCC_DBOX_1	476:484	Mutation altering degron motif	0.719
p.N747D	SIDM01619	Endometrial Carcinoma	GDSC	INVHED	LIG_APCC_ABBA_1	738:743	Mutation rewiring degron network	0.2222
p.R742H	ACH-000520	Ovarian Cancer	CCLE	INVHED	LIG_APCC_ABBA_1	738:743	Mutation altering degron motif	0.8244
p.Y470H	ACH-001206	Bone Cancer	CCLE	ERGILPGVR	DEG_APCC_DBOX_1	476:484	Mutation blocking phosphorylation signal	0.6111
p.R741H	PF-382	haematopoietic and lymphoid tissue	COSMIC	INVHED	LIG_APCC_ABBA_1	738:743	Mutation altering degron motif	0.8244
p.L751I	COR-L95	lung	COSMIC	INVHED	LIG_APCC_ABBA_1	738:743	Mutation substituting flanking lysine	0.2222
p.L753R	DOHH-2	haematopoietic and lymphoid tissue	COSMIC	INVHED	LIG_APCC_ABBA_1	738:743	Mutation rewiring degron network	0.0556
p.S739F	HCC2998	large intestine	COSMIC	INVHED	LIG_APCC_ABBA_1	738:743	Mutation altering degron motif	0.7982
p.R473Q	SNU-175	large intestine	COSMIC	ERGILPGVR	DEG_APCC_DBOX_1	476:484	Mutation rewiring degron network	0.25
p.E728D	GAK	skin	COSMIC	INVHED	LIG_APCC_ABBA_1	738:743	Mutation rewiring degron network	0.0556

Kaplan plot for NEK1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NEK1

UniProt ID: Q96PY6

Entrez ID: 4750

Protein name: Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NEK1 in