DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
INVHED
Uniprot ID:
Q96PY6
Source protein:
Serine/threonine-protein kinase Nek1
Source gene:
NEK1
Class:
LIG_APCC_ABBA_1
Location:
738:743
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9617
ASA_SCORE:
98.5833
COIL:
0.5498
CONS_SCORE:
0.4208
DSS_SCORE:
0.5614
HELIX:
0.4303
FCONS_SCORE:
1.0127
RIG_SCORE:
0.743
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.D753Y
TCGA-CA-6717
COAD
TCGA
INVHED
LIG_APCC_ABBA_1
0.0556
p.R742C
TCGA-YG-AA3O
SKCM
TCGA
INVHED
LIG_APCC_ABBA_1
0.8301
p.R741C
DO51734
COAD
ICGC
INVHED
LIG_APCC_ABBA_1
0.8301
p.R741C
DO43186
UCEC
ICGC
INVHED
LIG_APCC_ABBA_1
0.8301
p.E752G
DO229013
COCA
ICGC
INVHED
LIG_APCC_ABBA_1
0.0833
p.E752G
DO229003
COCA
ICGC
INVHED
LIG_APCC_ABBA_1
0.0833
p.E752G
DO229005
COCA
ICGC
INVHED
LIG_APCC_ABBA_1
0.0833
p.E752G
DO228941
LICA
ICGC
INVHED
LIG_APCC_ABBA_1
0.0833
p.N747D
SIDM01619
Endometrial Carcinoma
GDSC
INVHED
LIG_APCC_ABBA_1
0.2222
p.R742H
ACH-000520
Ovarian Cancer
CCLE
INVHED
LIG_APCC_ABBA_1
0.8244
p.R741H
PF-382
haematopoietic_and_lymphoid_tissue
COSMIC
INVHED
LIG_APCC_ABBA_1
0.8244
p.L751I
COR-L95
lung
COSMIC
INVHED
LIG_APCC_ABBA_1
0.2222
p.L753R
DOHH-2
haematopoietic_and_lymphoid_tissue
COSMIC
INVHED
LIG_APCC_ABBA_1
0.0556
p.S739F
HCC2998
large_intestine
COSMIC
INVHED
LIG_APCC_ABBA_1
0.7982
p.E728D
GAK
skin
COSMIC
INVHED
LIG_APCC_ABBA_1
0.0556
Drug responses associated with NEK1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of INVHED
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96PY6
Serine/threonine-protein kinase Nek1
LIG_APCC_ABBA_1
738:743
INVHED
APC,CDC20,FZR1
0.9617
More...