DegronMD

Uniprot ID: Q96PY6

Source protein: Serine/threonine-protein kinase Nek1

Source gene: NEK1

Class: LIG_APCC_ABBA_1

Location: 738:743

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9617

ASA_SCORE: 98.5833

COIL: 0.5498

CONS_SCORE: 0.4208

DSS_SCORE: 0.5614

HELIX: 0.4303

FCONS_SCORE: 1.0127

RIG_SCORE: 0.743

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R742C	TCGA-YG-AA3O	SKCM	TCGA	INVHED	LIG_APCC_ABBA_1	0.8301
p.R741C	DO51734	COAD	ICGC	INVHED	LIG_APCC_ABBA_1	0.8301
p.R741C	DO43186	UCEC	ICGC	INVHED	LIG_APCC_ABBA_1	0.8301
p.R742H	ACH-000520	Ovarian Cancer	CCLE	INVHED	LIG_APCC_ABBA_1	0.8244
p.R741H	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	INVHED	LIG_APCC_ABBA_1	0.8244
p.S739F	HCC2998	large_intestine	COSMIC	INVHED	LIG_APCC_ABBA_1	0.7982
p.N747D	SIDM01619	Endometrial Carcinoma	GDSC	INVHED	LIG_APCC_ABBA_1	0.2222
p.L751I	COR-L95	lung	COSMIC	INVHED	LIG_APCC_ABBA_1	0.2222
p.E752G	DO229013	COCA	ICGC	INVHED	LIG_APCC_ABBA_1	0.0833
p.E752G	DO229003	COCA	ICGC	INVHED	LIG_APCC_ABBA_1	0.0833
p.E752G	DO229005	COCA	ICGC	INVHED	LIG_APCC_ABBA_1	0.0833
p.E752G	DO228941	LICA	ICGC	INVHED	LIG_APCC_ABBA_1	0.0833
p.D753Y	TCGA-CA-6717	COAD	TCGA	INVHED	LIG_APCC_ABBA_1	0.0556
p.L753R	DOHH-2	haematopoietic_and_lymphoid_tissue	COSMIC	INVHED	LIG_APCC_ABBA_1	0.0556
p.E728D	GAK	skin	COSMIC	INVHED	LIG_APCC_ABBA_1	0.0556

Showing 1 to 15 of 15 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96PY6	Serine/threonine-protein kinase Nek1	LIG_APCC_ABBA_1	738:743	INVHED	APC,CDC20,FZR1	0.9617	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons