DegronMD

Uniprot ID: Q562E7

Source protein: WD repeat-containing protein 81

Source gene: WDR81

Class: DEG_APCC_DBOX_1

Location: 838:846

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7766

ASA_SCORE: 77.8778

COIL: 0.5992

CONS_SCORE: 0.4088

DSS_SCORE: 0.4509

HELIX: 0.3064

FCONS_SCORE: 1.0784

RIG_SCORE: 0.7464

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E832K	TCGA-2W-A8YY	CESC	TCGA	ERGKLDQLF	DEG_APCC_DBOX_1	0.1667
p.E832K	TCGA-B5-A3FC	UCEC	TCGA	ERGKLDQLF	DEG_APCC_DBOX_1	0.1667
p.E832K	DO223732	CESC	ICGC	ERGKLDQLF	DEG_APCC_DBOX_1	0.1667
p.E832K	DO41871	UCEC	ICGC	ERGKLDQLF	DEG_APCC_DBOX_1	0.1667
p.P850H	TCGA-AD-5900	COAD	TCGA	ERGKLDQLF	DEG_APCC_DBOX_1	0.2222
p.P850H	DO8514	COAD	ICGC	ERGKLDQLF	DEG_APCC_DBOX_1	0.2222
p.L855M	TCGA-BS-A0UF	UCEC	TCGA	ERGKLDQLF	DEG_APCC_DBOX_1	0.0833
p.L855M	DO41488	UCEC	ICGC	ERGKLDQLF	DEG_APCC_DBOX_1	0.0833
p.S829R	SIDM02039	Colorectal Carcinoma	GDSC	ERGKLDQLF	DEG_APCC_DBOX_1	0.0833
p.S850L	NCI-H1436	lung	COSMIC	ERGKLDQLF	DEG_APCC_DBOX_1	0.2222
p.E830K	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	ERGKLDQLF	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q562E7	WD repeat-containing protein 81	DEG_APCC_DBOX_1	838:846	ERGKLDQLF	APC,CDC20,FZR1	0.7766	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons