DegronMD - Q562E7(WDR81)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E832K	TCGA-2W-A8YY	CESC	TCGA	ERGKLDQLF	DEG_APCC_DBOX_1	838:846	Mutation rewiring degron network	0.1667
p.E832K	TCGA-B5-A3FC	UCEC	TCGA	ERGKLDQLF	DEG_APCC_DBOX_1	838:846	Mutation rewiring degron network	0.1667
p.E832K	DO223732	CESC	ICGC	ERGKLDQLF	DEG_APCC_DBOX_1	838:846	Mutation rewiring degron network	0.1667
p.E832K	DO41871	UCEC	ICGC	ERGKLDQLF	DEG_APCC_DBOX_1	838:846	Mutation rewiring degron network	0.1667
p.R1913C	TCGA-2W-A8YY	CESC	TCGA	FRGTLTSLA	DEG_APCC_DBOX_1	1912:1920	Mutation altering degron motif	0.8301
p.R1913C	TCGA-FI-A2D5	UCEC	TCGA	FRGTLTSLA	DEG_APCC_DBOX_1	1912:1920	Mutation altering degron motif	0.8301
p.R1913C	DO223732	CESC	ICGC	FRGTLTSLA	DEG_APCC_DBOX_1	1912:1920	Mutation altering degron motif	0.8301
p.R1913C	DO41331	UCEC	ICGC	FRGTLTSLA	DEG_APCC_DBOX_1	1912:1920	Mutation altering degron motif	0.8301
p.R1926H	TCGA-2W-A8YY	CESC	TCGA	FRGTLTSLA	DEG_APCC_DBOX_1	1912:1920	Mutation rewiring degron network	0.1667
p.R1926H	DO223732	CESC	ICGC	FRGTLTSLA	DEG_APCC_DBOX_1	1912:1920	Mutation rewiring degron network	0.1667
p.P850H	TCGA-AD-5900	COAD	TCGA	ERGKLDQLF	DEG_APCC_DBOX_1	838:846	Mutation rewiring degron network	0.2222
p.P850H	DO8514	COAD	ICGC	ERGKLDQLF	DEG_APCC_DBOX_1	838:846	Mutation rewiring degron network	0.2222
p.P600L	TCGA-B1-A47N	KIRP	TCGA	LAPEPPLIPKLLV	DEG_ODPH_VHL_1	598:610	Mutation altering degron motif	0.7582
p.P600L	DO49738	KIRP	ICGC	LAPEPPLIPKLLV	DEG_ODPH_VHL_1	598:610	Mutation altering degron motif	0.7582
p.G1914D	TCGA-BR-6452	STAD	TCGA	FRGTLTSLA	DEG_APCC_DBOX_1	1912:1920	Mutation altering degron motif	0.6087
p.G1914D	DO38404	STAD	ICGC	FRGTLTSLA	DEG_APCC_DBOX_1	1912:1920	Mutation altering degron motif	0.6087
p.L855M	TCGA-BS-A0UF	UCEC	TCGA	ERGKLDQLF	DEG_APCC_DBOX_1	838:846	Mutation rewiring degron network	0.0833
p.L855M	DO41488	UCEC	ICGC	ERGKLDQLF	DEG_APCC_DBOX_1	838:846	Mutation rewiring degron network	0.0833
p.E620D	TCGA-D5-6530	COAD	TCGA	LAPEPPLIPKLLV	DEG_ODPH_VHL_1	598:610	Mutation rewiring degron network	0.0556
p.E620D	DO8312	COAD	ICGC	LAPEPPLIPKLLV	DEG_ODPH_VHL_1	598:610	Mutation rewiring degron network	0.0556
p.G1914S	TCGA-DK-A3WW	BLCA	TCGA	FRGTLTSLA	DEG_APCC_DBOX_1	1912:1920	Mutation altering degron motif	0.5882
p.G1914S	DO481	BLCA	ICGC	FRGTLTSLA	DEG_APCC_DBOX_1	1912:1920	Mutation altering degron motif	0.5882
p.G1914S	DO47817	STAD	ICGC	FRGTLTSLA	DEG_APCC_DBOX_1	1912:1920	Mutation altering degron motif	0.5882
p.R1913S	TCGA-EE-A2A1	SKCM	TCGA	FRGTLTSLA	DEG_APCC_DBOX_1	1912:1920	Mutation altering degron motif	0.7427
p.R1913S	DO38045	SKCM	ICGC	FRGTLTSLA	DEG_APCC_DBOX_1	1912:1920	Mutation altering degron motif	0.7427
p.A1903V	TCGA-EY-A215	UCEC	TCGA	FRGTLTSLA	DEG_APCC_DBOX_1	1912:1920	Mutation rewiring degron network	0.0833
p.A1903V	DO42665	UCEC	ICGC	FRGTLTSLA	DEG_APCC_DBOX_1	1912:1920	Mutation rewiring degron network	0.0833
p.G618S	DO222816	COCA	ICGC	LAPEPPLIPKLLV	DEG_ODPH_VHL_1	598:610	Mutation rewiring degron network	0.1111
p.Q1902H	DO228377	LICA	ICGC	FRGTLTSLA	DEG_APCC_DBOX_1	1912:1920	Mutation rewiring degron network	0.0556
p.A595S	DO23508	LIRI	ICGC	LAPEPPLIPKLLV	DEG_ODPH_VHL_1	598:610	Mutation rewiring degron network	0.25
p.T1915M	DO227822	PBCA	ICGC	FRGTLTSLA	DEG_APCC_DBOX_1	1912:1920	Mutation altering degron motif	0.7423
p.S829R	SIDM02039	Colorectal Carcinoma	GDSC	ERGKLDQLF	DEG_APCC_DBOX_1	838:846	Mutation rewiring degron network	0.0833
p.R591C	SIDM02019	Colorectal Carcinoma	GDSC	LAPEPPLIPKLLV	DEG_ODPH_VHL_1	598:610	Mutation rewiring degron network	0.1389
p.E1910D	SIDM00683	Prostate Carcinoma	GDSC	FRGTLTSLA	DEG_APCC_DBOX_1	1912:1920	Mutation rewiring degron network	0.2778
p.E1910D	ACH-000977	lymph node	CCLE	FRGTLTSLA	DEG_APCC_DBOX_1	1912:1920	Mutation rewiring degron network	0.2778
p.E1910D	LNCaP-Clone-FGC	prostate	COSMIC	FRGTLTSLA	DEG_APCC_DBOX_1	1912:1920	Mutation rewiring degron network	0.2778
p.S1909Y	SIDM00789	Colorectal Carcinoma	GDSC	FRGTLTSLA	DEG_APCC_DBOX_1	1912:1920	Mutation rewiring degron network	0.25
p.S1909Y	ACH-000997	Colon/Colorectal Cancer	CCLE	FRGTLTSLA	DEG_APCC_DBOX_1	1912:1920	Mutation rewiring degron network	0.25
p.S1909Y	ACH-001061	Colon/Colorectal Cancer	CCLE	FRGTLTSLA	DEG_APCC_DBOX_1	1912:1920	Mutation rewiring degron network	0.25
p.S1909Y	HCT-15	large intestine	COSMIC	FRGTLTSLA	DEG_APCC_DBOX_1	1912:1920	Mutation rewiring degron network	0.25
p.R619Q	SIDM00449	B-Lymphoblastic Leukemia	GDSC	LAPEPPLIPKLLV	DEG_ODPH_VHL_1	598:610	Mutation rewiring degron network	0.0833
p.R619Q	ACH-000922	Leukemia	CCLE	LAPEPPLIPKLLV	DEG_ODPH_VHL_1	598:610	Mutation rewiring degron network	0.0833
p.R619Q	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	LAPEPPLIPKLLV	DEG_ODPH_VHL_1	598:610	Mutation rewiring degron network	0.0833
p.R619W	SIDM00596	Endometrial Carcinoma	GDSC	LAPEPPLIPKLLV	DEG_ODPH_VHL_1	598:610	Mutation rewiring degron network	0.0833
p.R619W	ACH-000941	Endometrial/Uterine Cancer	CCLE	LAPEPPLIPKLLV	DEG_ODPH_VHL_1	598:610	Mutation rewiring degron network	0.0833
p.R619W	ACH-000954	Endometrial/Uterine Cancer	CCLE	LAPEPPLIPKLLV	DEG_ODPH_VHL_1	598:610	Mutation rewiring degron network	0.0833
p.R619W	ACH-001517	Endometrial/Uterine Cancer	CCLE	LAPEPPLIPKLLV	DEG_ODPH_VHL_1	598:610	Mutation rewiring degron network	0.0833
p.R619W	HEC-1	endometrium	COSMIC	LAPEPPLIPKLLV	DEG_ODPH_VHL_1	598:610	Mutation rewiring degron network	0.0833
p.V603M	SCC-25	upper aerodigestive tract	COSMIC	LAPEPPLIPKLLV	DEG_ODPH_VHL_1	598:610	Mutation altering degron motif	0.7208
p.S613N	KM12	large intestine	COSMIC	LAPEPPLIPKLLV	DEG_ODPH_VHL_1	598:610	Mutation rewiring degron network	0.25
p.T590I	Jurkat	haematopoietic and lymphoid tissue	COSMIC	LAPEPPLIPKLLV	DEG_ODPH_VHL_1	598:610	Mutation rewiring degron network	0.1111
p.S850L	NCI-H1436	lung	COSMIC	ERGKLDQLF	DEG_APCC_DBOX_1	838:846	Mutation rewiring degron network	0.2222
p.E830K	PF-382	haematopoietic and lymphoid tissue	COSMIC	ERGKLDQLF	DEG_APCC_DBOX_1	838:846	Mutation rewiring degron network	0.1111
p.A599T	JHH-7	liver	COSMIC	LAPEPPLIPKLLV	DEG_ODPH_VHL_1	598:610	Mutation altering degron motif	0.7139
p.R619C	MZ7-mel	skin	COSMIC	LAPEPPLIPKLLV	DEG_ODPH_VHL_1	598:610	Mutation rewiring degron network	0.0833
p.R619H	SNU-283	large intestine	COSMIC	LAPEPPLIPKLLV	DEG_ODPH_VHL_1	598:610	Mutation rewiring degron network	0.0833
p.T614I	Jurkat	haematopoietic and lymphoid tissue	COSMIC	LAPEPPLIPKLLV	DEG_ODPH_VHL_1	598:610	Mutation rewiring degron network	0.2222
p.R589C	VA-ES-BJ	bone	COSMIC	LAPEPPLIPKLLV	DEG_ODPH_VHL_1	598:610	Mutation rewiring degron network	0.0833

Kaplan plot for WDR81 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

WDR81

UniProt ID: Q562E7

Entrez ID: 124997

Protein name: WD repeat-containing protein 81

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for WDR81 in