DegronMD

Uniprot ID: Q562E7

Source protein: WD repeat-containing protein 81

Source gene: WDR81

Class: DEG_ODPH_VHL_1

Location: 598:610

E3 ligase: VHL

DEGRON score: 0.5749

ASA_SCORE: 68.0385

COIL: 0.7054

CONS_SCORE: 0.402

DSS_SCORE: 0.4755

HELIX: 0.2437

FCONS_SCORE: 0.8594

RIG_SCORE: 0.7479

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P600L	TCGA-B1-A47N	KIRP	TCGA	LAPEPPLIPKLLV	DEG_ODPH_VHL_1	0.7582
p.P600L	DO49738	KIRP	ICGC	LAPEPPLIPKLLV	DEG_ODPH_VHL_1	0.7582
p.E620D	TCGA-D5-6530	COAD	TCGA	LAPEPPLIPKLLV	DEG_ODPH_VHL_1	0.0556
p.E620D	DO8312	COAD	ICGC	LAPEPPLIPKLLV	DEG_ODPH_VHL_1	0.0556
p.G618S	DO222816	COCA	ICGC	LAPEPPLIPKLLV	DEG_ODPH_VHL_1	0.1111
p.A595S	DO23508	LIRI	ICGC	LAPEPPLIPKLLV	DEG_ODPH_VHL_1	0.25
p.R591C	SIDM02019	Colorectal Carcinoma	GDSC	LAPEPPLIPKLLV	DEG_ODPH_VHL_1	0.1389
p.R619Q	SIDM00449	B-Lymphoblastic Leukemia	GDSC	LAPEPPLIPKLLV	DEG_ODPH_VHL_1	0.0833
p.R619Q	ACH-000922	Leukemia	CCLE	LAPEPPLIPKLLV	DEG_ODPH_VHL_1	0.0833
p.R619Q	RCH-ACV	haematopoietic_and_lymphoid_tissue	COSMIC	LAPEPPLIPKLLV	DEG_ODPH_VHL_1	0.0833
p.R619W	SIDM00596	Endometrial Carcinoma	GDSC	LAPEPPLIPKLLV	DEG_ODPH_VHL_1	0.0833
p.R619W	ACH-000941	Endometrial/Uterine Cancer	CCLE	LAPEPPLIPKLLV	DEG_ODPH_VHL_1	0.0833
p.R619W	ACH-000954	Endometrial/Uterine Cancer	CCLE	LAPEPPLIPKLLV	DEG_ODPH_VHL_1	0.0833
p.R619W	ACH-001517	Endometrial/Uterine Cancer	CCLE	LAPEPPLIPKLLV	DEG_ODPH_VHL_1	0.0833
p.R619W	HEC-1	endometrium	COSMIC	LAPEPPLIPKLLV	DEG_ODPH_VHL_1	0.0833
p.V603M	SCC-25	upper_aerodigestive_tract	COSMIC	LAPEPPLIPKLLV	DEG_ODPH_VHL_1	0.7208
p.S613N	KM12	large_intestine	COSMIC	LAPEPPLIPKLLV	DEG_ODPH_VHL_1	0.25
p.T590I	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	LAPEPPLIPKLLV	DEG_ODPH_VHL_1	0.1111
p.A599T	JHH-7	liver	COSMIC	LAPEPPLIPKLLV	DEG_ODPH_VHL_1	0.7139
p.R619C	MZ7-mel	skin	COSMIC	LAPEPPLIPKLLV	DEG_ODPH_VHL_1	0.0833
p.R619H	SNU-283	large_intestine	COSMIC	LAPEPPLIPKLLV	DEG_ODPH_VHL_1	0.0833
p.T614I	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	LAPEPPLIPKLLV	DEG_ODPH_VHL_1	0.2222
p.R589C	VA-ES-BJ	bone	COSMIC	LAPEPPLIPKLLV	DEG_ODPH_VHL_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPEPPLIPKLLV

Degron related mutations and impact score

Drug responses associated with WDR81 mutations

All proteins holding degron of LAPEPPLIPKLLV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q562E7	WD repeat-containing protein 81	DEG_ODPH_VHL_1	598:610	LAPEPPLIPKLLV	VHL	0.5749	More...