DegronMD

Uniprot ID: Q562E7

Source protein: WD repeat-containing protein 81

Source gene: WDR81

Class: DEG_APCC_DBOX_1

Location: 1912:1920

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6212

ASA_SCORE: 27.5444

COIL: 0.4254

CONS_SCORE: 0

DSS_SCORE: 0.2203

HELIX: 0.0072

FCONS_SCORE: 0

RIG_SCORE: 0.8001

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1913C	TCGA-2W-A8YY	CESC	TCGA	FRGTLTSLA	DEG_APCC_DBOX_1	0.8301
p.R1913C	TCGA-FI-A2D5	UCEC	TCGA	FRGTLTSLA	DEG_APCC_DBOX_1	0.8301
p.R1913C	DO223732	CESC	ICGC	FRGTLTSLA	DEG_APCC_DBOX_1	0.8301
p.R1913C	DO41331	UCEC	ICGC	FRGTLTSLA	DEG_APCC_DBOX_1	0.8301
p.R1926H	TCGA-2W-A8YY	CESC	TCGA	FRGTLTSLA	DEG_APCC_DBOX_1	0.1667
p.R1926H	DO223732	CESC	ICGC	FRGTLTSLA	DEG_APCC_DBOX_1	0.1667
p.G1914D	TCGA-BR-6452	STAD	TCGA	FRGTLTSLA	DEG_APCC_DBOX_1	0.6087
p.G1914D	DO38404	STAD	ICGC	FRGTLTSLA	DEG_APCC_DBOX_1	0.6087
p.G1914S	TCGA-DK-A3WW	BLCA	TCGA	FRGTLTSLA	DEG_APCC_DBOX_1	0.5882
p.G1914S	DO481	BLCA	ICGC	FRGTLTSLA	DEG_APCC_DBOX_1	0.5882
p.G1914S	DO47817	STAD	ICGC	FRGTLTSLA	DEG_APCC_DBOX_1	0.5882
p.R1913S	TCGA-EE-A2A1	SKCM	TCGA	FRGTLTSLA	DEG_APCC_DBOX_1	0.7427
p.R1913S	DO38045	SKCM	ICGC	FRGTLTSLA	DEG_APCC_DBOX_1	0.7427
p.A1903V	TCGA-EY-A215	UCEC	TCGA	FRGTLTSLA	DEG_APCC_DBOX_1	0.0833
p.A1903V	DO42665	UCEC	ICGC	FRGTLTSLA	DEG_APCC_DBOX_1	0.0833
p.Q1902H	DO228377	LICA	ICGC	FRGTLTSLA	DEG_APCC_DBOX_1	0.0556
p.T1915M	DO227822	PBCA	ICGC	FRGTLTSLA	DEG_APCC_DBOX_1	0.7423
p.E1910D	SIDM00683	Prostate Carcinoma	GDSC	FRGTLTSLA	DEG_APCC_DBOX_1	0.2778
p.E1910D	ACH-000977	lymph_node	CCLE	FRGTLTSLA	DEG_APCC_DBOX_1	0.2778
p.E1910D	LNCaP-Clone-FGC	prostate	COSMIC	FRGTLTSLA	DEG_APCC_DBOX_1	0.2778
p.S1909Y	SIDM00789	Colorectal Carcinoma	GDSC	FRGTLTSLA	DEG_APCC_DBOX_1	0.25
p.S1909Y	ACH-000997	Colon/Colorectal Cancer	CCLE	FRGTLTSLA	DEG_APCC_DBOX_1	0.25
p.S1909Y	ACH-001061	Colon/Colorectal Cancer	CCLE	FRGTLTSLA	DEG_APCC_DBOX_1	0.25
p.S1909Y	HCT-15	large_intestine	COSMIC	FRGTLTSLA	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q562E7	WD repeat-containing protein 81	DEG_APCC_DBOX_1	1912:1920	FRGTLTSLA	APC,CDC20,FZR1	0.6212	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons