DegronMD

Uniprot ID: O60494

Source protein: Cubilin

Source gene: CUBN

Class: DEG_APCC_DBOX_1

Location: 47:55

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8085

ASA_SCORE: 51.0222

COIL: 0.4552

CONS_SCORE: 0.4036

DSS_SCORE: 0.3581

HELIX: 0.0193

FCONS_SCORE: 1.0813

RIG_SCORE: 0.7895

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T46I	TCGA-A5-A0GH	UCEC	TCGA	ERGNLVFLT	DEG_APCC_DBOX_1	0.3056
p.T46I	DO43634	UCEC	ICGC	ERGNLVFLT	DEG_APCC_DBOX_1	0.3056
p.P42H	TCGA-DA-A1I1	SKCM	TCGA	ERGNLVFLT	DEG_APCC_DBOX_1	0.1944
p.P42H	DO37966	SKCM	ICGC	ERGNLVFLT	DEG_APCC_DBOX_1	0.1944
p.R64I	TCGA-DK-A6AW	BLCA	TCGA	ERGNLVFLT	DEG_APCC_DBOX_1	0.0833
p.R64I	DO48566	BLCA	ICGC	ERGNLVFLT	DEG_APCC_DBOX_1	0.0833
p.N50T	TCGA-IC-A6RE	ESCA	TCGA	ERGNLVFLT	DEG_APCC_DBOX_1	0.5944
p.N50T	DO232061	ORCA	ICGC	ERGNLVFLT	DEG_APCC_DBOX_1	0.5944
p.N38S	TCGA-VS-A9UO	CESC	TCGA	ERGNLVFLT	DEG_APCC_DBOX_1	0.0833
p.N38S	DO219736	CESC	ICGC	ERGNLVFLT	DEG_APCC_DBOX_1	0.0833
p.F53L	TCGA-ZS-A9CF	LIHC	TCGA	ERGNLVFLT	DEG_APCC_DBOX_1	0.587
p.F53L	DO49722	LIHC	ICGC	ERGNLVFLT	DEG_APCC_DBOX_1	0.587
p.T55M	DO222421	BTCA	ICGC	ERGNLVFLT	DEG_APCC_DBOX_1	0.6312
p.T55M	DO224620	COCA	ICGC	ERGNLVFLT	DEG_APCC_DBOX_1	0.6312
p.T55M	SIDM00217	Colorectal Carcinoma	GDSC	ERGNLVFLT	DEG_APCC_DBOX_1	0.6312
p.T55M	ACH-000999	Colon/Colorectal Cancer	CCLE	ERGNLVFLT	DEG_APCC_DBOX_1	0.6312
p.T55M	SNU-1040	large_intestine	COSMIC	ERGNLVFLT	DEG_APCC_DBOX_1	0.6312
p.N60S	DO222798	COCA	ICGC	ERGNLVFLT	DEG_APCC_DBOX_1	0.1944
p.E62G	DO231941	LICA	ICGC	ERGNLVFLT	DEG_APCC_DBOX_1	0.1389
p.A58D	DO229027	LICA	ICGC	ERGNLVFLT	DEG_APCC_DBOX_1	0.25
p.T65N	DO229009	LICA	ICGC	ERGNLVFLT	DEG_APCC_DBOX_1	0.0556
p.I37L	SIDM00933	Breast Carcinoma	GDSC	ERGNLVFLT	DEG_APCC_DBOX_1	0.0556
p.I37L	SIDM00773	Non-Cancerous	GDSC	ERGNLVFLT	DEG_APCC_DBOX_1	0.0556
p.I37L	SIDM00969	Ovarian Carcinoma	GDSC	ERGNLVFLT	DEG_APCC_DBOX_1	0.0556
p.I37L	SIDM00454	Rhabdomyosarcoma	GDSC	ERGNLVFLT	DEG_APCC_DBOX_1	0.0556
p.I37L	SIDM01245	T-Lymphoblastic Leukemia	GDSC	ERGNLVFLT	DEG_APCC_DBOX_1	0.0556
p.I37L	SIDM00690	Head and Neck Carcinoma	GDSC	ERGNLVFLT	DEG_APCC_DBOX_1	0.0556
p.I37L	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	ERGNLVFLT	DEG_APCC_DBOX_1	0.0556
p.I37L	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	ERGNLVFLT	DEG_APCC_DBOX_1	0.0556
p.I37L	SIDM00254	Neuroblastoma	GDSC	ERGNLVFLT	DEG_APCC_DBOX_1	0.0556
p.I37L	SIDM00875	Breast Carcinoma	GDSC	ERGNLVFLT	DEG_APCC_DBOX_1	0.0556
p.I37L	SIDM00907	Burkitt's Lymphoma	GDSC	ERGNLVFLT	DEG_APCC_DBOX_1	0.0556
p.I37L	SIDM00882	Breast Carcinoma	GDSC	ERGNLVFLT	DEG_APCC_DBOX_1	0.0556
p.I37L	SIDM00068	Colorectal Carcinoma	GDSC	ERGNLVFLT	DEG_APCC_DBOX_1	0.0556
p.I37L	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	ERGNLVFLT	DEG_APCC_DBOX_1	0.0556
p.I37L	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	ERGNLVFLT	DEG_APCC_DBOX_1	0.0556
p.I37L	SIDM00774	Breast Carcinoma	GDSC	ERGNLVFLT	DEG_APCC_DBOX_1	0.0556
p.I37L	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	ERGNLVFLT	DEG_APCC_DBOX_1	0.0556
p.I37L	SIDM00991	T-Lymphoblastic Leukemia	GDSC	ERGNLVFLT	DEG_APCC_DBOX_1	0.0556
p.I37L	SIDM01525	Acute Myeloid Leukemia	GDSC	ERGNLVFLT	DEG_APCC_DBOX_1	0.0556
p.R43Q	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	ERGNLVFLT	DEG_APCC_DBOX_1	0.2222
p.R43L	SIDM00344	Non-Small Cell Lung Carcinoma	GDSC	ERGNLVFLT	DEG_APCC_DBOX_1	0.2222
p.R43L	ACH-000596	Lung Cancer	CCLE	ERGNLVFLT	DEG_APCC_DBOX_1	0.2222
p.R43L	LCLC-97TM1	lung	COSMIC	ERGNLVFLT	DEG_APCC_DBOX_1	0.2222
p.Q59E	SIDM01170	Ovarian Carcinoma	GDSC	ERGNLVFLT	DEG_APCC_DBOX_1	0.2222
p.Q59E	ACH-000048	Ovarian Cancer	CCLE	ERGNLVFLT	DEG_APCC_DBOX_1	0.2222
p.Q59E	TOV-112D	ovary	COSMIC	ERGNLVFLT	DEG_APCC_DBOX_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ERGNLVFLT

Degron related mutations and impact score

Drug responses associated with CUBN mutations

All proteins holding degron of ERGNLVFLT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60494	Cubilin	DEG_APCC_DBOX_1	47:55	ERGNLVFLT	APC,CDC20,FZR1	0.8085	More...