DegronMD - O60494(CUBN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G1955E	TCGA-06-5416	GBM	TCGA	FLLEWFAV	DEG_MDM2_SWIB_1	1956:1963	Mutation rewiring degron network	0.3056
p.G1955E	DO10880	GBM	ICGC	FLLEWFAV	DEG_MDM2_SWIB_1	1956:1963	Mutation rewiring degron network	0.3056
p.G1955E	DO222843	MELA	ICGC	FLLEWFAV	DEG_MDM2_SWIB_1	1956:1963	Mutation rewiring degron network	0.3056
p.D1967N	TCGA-4Z-AA81	BLCA	TCGA	FLLEWFAV	DEG_MDM2_SWIB_1	1956:1963	Mutation rewiring degron network	0.2222
p.D1967N	DO51868	BLCA	ICGC	FLLEWFAV	DEG_MDM2_SWIB_1	1956:1963	Mutation rewiring degron network	0.2222
p.T46I	TCGA-A5-A0GH	UCEC	TCGA	ERGNLVFLT	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.3056
p.T46I	DO43634	UCEC	ICGC	ERGNLVFLT	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.3056
p.D1948N	TCGA-AX-A2HC	UCEC	TCGA	FLLEWFAV	DEG_MDM2_SWIB_1	1956:1963	Mutation rewiring degron network	0.1111
p.D1948N	DO41572	UCEC	ICGC	FLLEWFAV	DEG_MDM2_SWIB_1	1956:1963	Mutation rewiring degron network	0.1111
p.W1960L	TCGA-BF-A1PX	SKCM	TCGA	FLLEWFAV	DEG_MDM2_SWIB_1	1956:1963	Mutation altering degron motif	0.7015
p.W1960L	DO51236	SKCM	ICGC	FLLEWFAV	DEG_MDM2_SWIB_1	1956:1963	Mutation altering degron motif	0.7015
p.G1968D	TCGA-BR-4368	STAD	TCGA	FLLEWFAV	DEG_MDM2_SWIB_1	1956:1963	Mutation rewiring degron network	0.1944
p.G1968D	TCGA-ER-A193	SKCM	TCGA	FLLEWFAV	DEG_MDM2_SWIB_1	1956:1963	Mutation rewiring degron network	0.1944
p.G1968D	DO47368	SKCM	ICGC	FLLEWFAV	DEG_MDM2_SWIB_1	1956:1963	Mutation rewiring degron network	0.1944
p.G1968D	DO38715	STAD	ICGC	FLLEWFAV	DEG_MDM2_SWIB_1	1956:1963	Mutation rewiring degron network	0.1944
p.P42H	TCGA-DA-A1I1	SKCM	TCGA	ERGNLVFLT	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.1944
p.P42H	DO37966	SKCM	ICGC	ERGNLVFLT	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.1944
p.R64I	TCGA-DK-A6AW	BLCA	TCGA	ERGNLVFLT	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.0833
p.R64I	DO48566	BLCA	ICGC	ERGNLVFLT	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.0833
p.D1964N	TCGA-EE-A3JA	SKCM	TCGA	FLLEWFAV	DEG_MDM2_SWIB_1	1956:1963	Mutation rewiring degron network	0.3056
p.D1964N	DO47625	SKCM	ICGC	FLLEWFAV	DEG_MDM2_SWIB_1	1956:1963	Mutation rewiring degron network	0.3056
p.N50T	TCGA-IC-A6RE	ESCA	TCGA	ERGNLVFLT	DEG_APCC_DBOX_1	47:55	Mutation altering degron motif	0.5944
p.N50T	DO232061	ORCA	ICGC	ERGNLVFLT	DEG_APCC_DBOX_1	47:55	Mutation altering degron motif	0.5944
p.N38S	TCGA-VS-A9UO	CESC	TCGA	ERGNLVFLT	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.0833
p.N38S	DO219736	CESC	ICGC	ERGNLVFLT	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.0833
p.A1962V	TCGA-XK-AAIW	PRAD	TCGA	FLLEWFAV	DEG_MDM2_SWIB_1	1956:1963	Mutation altering degron motif	0.5825
p.A1962V	DO51407	PRAD	ICGC	FLLEWFAV	DEG_MDM2_SWIB_1	1956:1963	Mutation altering degron motif	0.5825
p.F53L	TCGA-ZS-A9CF	LIHC	TCGA	ERGNLVFLT	DEG_APCC_DBOX_1	47:55	Mutation altering degron motif	0.587
p.F53L	DO49722	LIHC	ICGC	ERGNLVFLT	DEG_APCC_DBOX_1	47:55	Mutation altering degron motif	0.587
p.T55M	DO222421	BTCA	ICGC	ERGNLVFLT	DEG_APCC_DBOX_1	47:55	Mutation altering degron motif	0.6312
p.T55M	DO224620	COCA	ICGC	ERGNLVFLT	DEG_APCC_DBOX_1	47:55	Mutation altering degron motif	0.6312
p.T55M	SIDM00217	Colorectal Carcinoma	GDSC	ERGNLVFLT	DEG_APCC_DBOX_1	47:55	Mutation altering degron motif	0.6312
p.T55M	ACH-000999	Colon/Colorectal Cancer	CCLE	ERGNLVFLT	DEG_APCC_DBOX_1	47:55	Mutation altering degron motif	0.6312
p.T55M	SNU-1040	large intestine	COSMIC	ERGNLVFLT	DEG_APCC_DBOX_1	47:55	Mutation altering degron motif	0.6312
p.N60S	DO222798	COCA	ICGC	ERGNLVFLT	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.1944
p.P1971T	DO229013	COCA	ICGC	FLLEWFAV	DEG_MDM2_SWIB_1	1956:1963	Mutation rewiring degron network	0.1111
p.P1971T	DO229003	COCA	ICGC	FLLEWFAV	DEG_MDM2_SWIB_1	1956:1963	Mutation rewiring degron network	0.1111
p.F1961C	DO228123	EOPC	ICGC	FLLEWFAV	DEG_MDM2_SWIB_1	1956:1963	Mutation altering degron motif	0.5996
p.E62G	DO231941	LICA	ICGC	ERGNLVFLT	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.1389
p.A58D	DO229027	LICA	ICGC	ERGNLVFLT	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.25
p.T65N	DO229009	LICA	ICGC	ERGNLVFLT	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.0556
p.F1961L	DO232852	NACA	ICGC	FLLEWFAV	DEG_MDM2_SWIB_1	1956:1963	Mutation altering degron motif	0.587
p.I37L	SIDM00933	Breast Carcinoma	GDSC	ERGNLVFLT	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.0556
p.I37L	SIDM00773	Non-Cancerous	GDSC	ERGNLVFLT	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.0556
p.I37L	SIDM00969	Ovarian Carcinoma	GDSC	ERGNLVFLT	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.0556
p.I37L	SIDM00454	Rhabdomyosarcoma	GDSC	ERGNLVFLT	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.0556
p.I37L	SIDM01245	T-Lymphoblastic Leukemia	GDSC	ERGNLVFLT	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.0556
p.I37L	SIDM00690	Head and Neck Carcinoma	GDSC	ERGNLVFLT	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.0556
p.I37L	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	ERGNLVFLT	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.0556
p.I37L	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	ERGNLVFLT	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.0556
p.I37L	SIDM00254	Neuroblastoma	GDSC	ERGNLVFLT	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.0556
p.I37L	SIDM00875	Breast Carcinoma	GDSC	ERGNLVFLT	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.0556
p.I37L	SIDM00907	Burkitt's Lymphoma	GDSC	ERGNLVFLT	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.0556
p.I37L	SIDM00882	Breast Carcinoma	GDSC	ERGNLVFLT	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.0556
p.I37L	SIDM00068	Colorectal Carcinoma	GDSC	ERGNLVFLT	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.0556
p.I37L	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	ERGNLVFLT	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.0556
p.I37L	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	ERGNLVFLT	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.0556
p.I37L	SIDM00774	Breast Carcinoma	GDSC	ERGNLVFLT	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.0556
p.I37L	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	ERGNLVFLT	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.0556
p.I37L	SIDM00991	T-Lymphoblastic Leukemia	GDSC	ERGNLVFLT	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.0556
p.I37L	SIDM01525	Acute Myeloid Leukemia	GDSC	ERGNLVFLT	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.0556
p.S1947Y	SIDM00269	Ewing's Sarcoma	GDSC	FLLEWFAV	DEG_MDM2_SWIB_1	1956:1963	Mutation rewiring degron network	0.0833
p.S1947Y	SIDM00387	Neuroblastoma	GDSC	FLLEWFAV	DEG_MDM2_SWIB_1	1956:1963	Mutation rewiring degron network	0.0833
p.E1959K	SIDM00683	Prostate Carcinoma	GDSC	FLLEWFAV	DEG_MDM2_SWIB_1	1956:1963	Mutation altering degron motif	0.591
p.E1959K	ACH-000977	lymph node	CCLE	FLLEWFAV	DEG_MDM2_SWIB_1	1956:1963	Mutation altering degron motif	0.591
p.E1959K	LNCaP-Clone-FGC	prostate	COSMIC	FLLEWFAV	DEG_MDM2_SWIB_1	1956:1963	Mutation altering degron motif	0.591
p.R43Q	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	ERGNLVFLT	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.2222
p.G1953E	SIDM00516	Melanoma	GDSC	FLLEWFAV	DEG_MDM2_SWIB_1	1956:1963	Mutation rewiring degron network	0.25
p.G1953E	ACH-002166	Skin Cancer	CCLE	FLLEWFAV	DEG_MDM2_SWIB_1	1956:1963	Mutation rewiring degron network	0.25
p.G1953E	MZ7-mel	skin	COSMIC	FLLEWFAV	DEG_MDM2_SWIB_1	1956:1963	Mutation rewiring degron network	0.25
p.R43L	SIDM00344	Non-Small Cell Lung Carcinoma	GDSC	ERGNLVFLT	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.2222
p.R43L	ACH-000596	Lung Cancer	CCLE	ERGNLVFLT	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.2222
p.R43L	LCLC-97TM1	lung	COSMIC	ERGNLVFLT	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.2222
p.Q59E	SIDM01170	Ovarian Carcinoma	GDSC	ERGNLVFLT	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.2222
p.Q59E	ACH-000048	Ovarian Cancer	CCLE	ERGNLVFLT	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.2222
p.Q59E	TOV-112D	ovary	COSMIC	ERGNLVFLT	DEG_APCC_DBOX_1	47:55	Mutation rewiring degron network	0.2222

Kaplan plot for CUBN in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CUBN

UniProt ID: O60494

Entrez ID: 8029

Protein name: Cubilin (460 kDa receptor) (Intestinal intrinsic factor receptor) (Intrinsic factor-cobalamin receptor) (Intrinsic factor-vitamin B12 receptor)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CUBN in