DegronMD

Uniprot ID: O60494

Source protein: Cubilin

Source gene: CUBN

Class: DEG_MDM2_SWIB_1

Location: 1956:1963

E3 ligase: MDM2

DEGRON score: 0.5402

ASA_SCORE: 22.6125

COIL: 0.0331

CONS_SCORE: 0.4978

DSS_SCORE: 0.0947

HELIX: 0.0019

FCONS_SCORE: 1.5284

RIG_SCORE: 0.9172

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1955E	TCGA-06-5416	GBM	TCGA	FLLEWFAV	DEG_MDM2_SWIB_1	0.3056
p.G1955E	DO10880	GBM	ICGC	FLLEWFAV	DEG_MDM2_SWIB_1	0.3056
p.G1955E	DO222843	MELA	ICGC	FLLEWFAV	DEG_MDM2_SWIB_1	0.3056
p.D1967N	TCGA-4Z-AA81	BLCA	TCGA	FLLEWFAV	DEG_MDM2_SWIB_1	0.2222
p.D1967N	DO51868	BLCA	ICGC	FLLEWFAV	DEG_MDM2_SWIB_1	0.2222
p.D1948N	TCGA-AX-A2HC	UCEC	TCGA	FLLEWFAV	DEG_MDM2_SWIB_1	0.1111
p.D1948N	DO41572	UCEC	ICGC	FLLEWFAV	DEG_MDM2_SWIB_1	0.1111
p.W1960L	TCGA-BF-A1PX	SKCM	TCGA	FLLEWFAV	DEG_MDM2_SWIB_1	0.7015
p.W1960L	DO51236	SKCM	ICGC	FLLEWFAV	DEG_MDM2_SWIB_1	0.7015
p.G1968D	TCGA-BR-4368	STAD	TCGA	FLLEWFAV	DEG_MDM2_SWIB_1	0.1944
p.G1968D	TCGA-ER-A193	SKCM	TCGA	FLLEWFAV	DEG_MDM2_SWIB_1	0.1944
p.G1968D	DO47368	SKCM	ICGC	FLLEWFAV	DEG_MDM2_SWIB_1	0.1944
p.G1968D	DO38715	STAD	ICGC	FLLEWFAV	DEG_MDM2_SWIB_1	0.1944
p.D1964N	TCGA-EE-A3JA	SKCM	TCGA	FLLEWFAV	DEG_MDM2_SWIB_1	0.3056
p.D1964N	DO47625	SKCM	ICGC	FLLEWFAV	DEG_MDM2_SWIB_1	0.3056
p.A1962V	TCGA-XK-AAIW	PRAD	TCGA	FLLEWFAV	DEG_MDM2_SWIB_1	0.5825
p.A1962V	DO51407	PRAD	ICGC	FLLEWFAV	DEG_MDM2_SWIB_1	0.5825
p.P1971T	DO229013	COCA	ICGC	FLLEWFAV	DEG_MDM2_SWIB_1	0.1111
p.P1971T	DO229003	COCA	ICGC	FLLEWFAV	DEG_MDM2_SWIB_1	0.1111
p.F1961C	DO228123	EOPC	ICGC	FLLEWFAV	DEG_MDM2_SWIB_1	0.5996
p.F1961L	DO232852	NACA	ICGC	FLLEWFAV	DEG_MDM2_SWIB_1	0.587
p.S1947Y	SIDM00269	Ewing's Sarcoma	GDSC	FLLEWFAV	DEG_MDM2_SWIB_1	0.0833
p.S1947Y	SIDM00387	Neuroblastoma	GDSC	FLLEWFAV	DEG_MDM2_SWIB_1	0.0833
p.E1959K	SIDM00683	Prostate Carcinoma	GDSC	FLLEWFAV	DEG_MDM2_SWIB_1	0.591
p.E1959K	ACH-000977	lymph_node	CCLE	FLLEWFAV	DEG_MDM2_SWIB_1	0.591
p.E1959K	LNCaP-Clone-FGC	prostate	COSMIC	FLLEWFAV	DEG_MDM2_SWIB_1	0.591
p.G1953E	SIDM00516	Melanoma	GDSC	FLLEWFAV	DEG_MDM2_SWIB_1	0.25
p.G1953E	ACH-002166	Skin Cancer	CCLE	FLLEWFAV	DEG_MDM2_SWIB_1	0.25
p.G1953E	MZ7-mel	skin	COSMIC	FLLEWFAV	DEG_MDM2_SWIB_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FLLEWFAV

Degron related mutations and impact score

Drug responses associated with CUBN mutations

All proteins holding degron of FLLEWFAV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60494	Cubilin	DEG_MDM2_SWIB_1	1956:1963	FLLEWFAV	MDM2	0.5402	More...