DegronMD

Uniprot ID: P59923

Source protein: Zinc finger protein 445

Source gene: ZNF445

Class: DEG_APCC_DBOX_1

Location: 19:27

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8505

ASA_SCORE: 100.6444

COIL: 0.5887

CONS_SCORE: 0.5551

DSS_SCORE: 0.6949

HELIX: 0.3486

FCONS_SCORE: 1.2367

RIG_SCORE: 0.6586

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y35C	TCGA-05-4405	LUAD	TCGA	ERGRLQTVK	DEG_APCC_DBOX_1	0.1111
p.Y35C	DO24656	LUAD	ICGC	ERGRLQTVK	DEG_APCC_DBOX_1	0.1111
p.Q15K	TCGA-37-3789	LUSC	TCGA	ERGRLQTVK	DEG_APCC_DBOX_1	0.2222
p.Q15K	DO26743	LUSC	ICGC	ERGRLQTVK	DEG_APCC_DBOX_1	0.2222
p.G21V	TCGA-49-6767	LUAD	TCGA	ERGRLQTVK	DEG_APCC_DBOX_1	0.6421
p.G21V	DO23586	LUAD	ICGC	ERGRLQTVK	DEG_APCC_DBOX_1	0.6421
p.S17L	TCGA-B5-A1MR	UCEC	TCGA	ERGRLQTVK	DEG_APCC_DBOX_1	0.2778
p.S17L	TCGA-EO-A3AV	UCEC	TCGA	ERGRLQTVK	DEG_APCC_DBOX_1	0.2778
p.S17L	TCGA-EY-A1G8	UCEC	TCGA	ERGRLQTVK	DEG_APCC_DBOX_1	0.2778
p.S17L	TCGA-F5-6814	READ	TCGA	ERGRLQTVK	DEG_APCC_DBOX_1	0.2778
p.S17L	DO36556	READ	ICGC	ERGRLQTVK	DEG_APCC_DBOX_1	0.2778
p.S17L	DO43578	UCEC	ICGC	ERGRLQTVK	DEG_APCC_DBOX_1	0.2778
p.S17L	DO52412	UCEC	ICGC	ERGRLQTVK	DEG_APCC_DBOX_1	0.2778
p.S17L	DO41758	UCEC	ICGC	ERGRLQTVK	DEG_APCC_DBOX_1	0.2778
p.S17L	SIDM02015	Colorectal Carcinoma	GDSC	ERGRLQTVK	DEG_APCC_DBOX_1	0.2778
p.A12T	TCGA-DF-A2KU	UCEC	TCGA	ERGRLQTVK	DEG_APCC_DBOX_1	0.1389
p.A12T	DO223286	UCEC	ICGC	ERGRLQTVK	DEG_APCC_DBOX_1	0.1389
p.Q13E	TCGA-FD-A3SO	BLCA	TCGA	ERGRLQTVK	DEG_APCC_DBOX_1	0.1667
p.Q13E	DO569	BLCA	ICGC	ERGRLQTVK	DEG_APCC_DBOX_1	0.1667
p.G21E	SIDM00917	Acute Myeloid Leukemia	GDSC	ERGRLQTVK	DEG_APCC_DBOX_1	0.6087
p.G21E	ACH-002218	Leukemia	CCLE	ERGRLQTVK	DEG_APCC_DBOX_1	0.6087
p.G21E	CESS	haematopoietic_and_lymphoid_tissue	COSMIC	ERGRLQTVK	DEG_APCC_DBOX_1	0.6087
p.R22Q	SIDM00999	Bladder Carcinoma	GDSC	ERGRLQTVK	DEG_APCC_DBOX_1	0.6218

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P59923	Zinc finger protein 445	DEG_APCC_DBOX_1	19:27	ERGRLQTVK	APC,CDC20,FZR1	0.8505	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons