DegronMD - P59923(ZNF445)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y35C	TCGA-05-4405	LUAD	TCGA	ERGRLQTVK	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.1111
p.Y35C	DO24656	LUAD	ICGC	ERGRLQTVK	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.1111
p.Q15K	TCGA-37-3789	LUSC	TCGA	ERGRLQTVK	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.2222
p.Q15K	DO26743	LUSC	ICGC	ERGRLQTVK	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.2222
p.G21V	TCGA-49-6767	LUAD	TCGA	ERGRLQTVK	DEG_APCC_DBOX_1	19:27	Mutation altering degron motif	0.6421
p.G21V	DO23586	LUAD	ICGC	ERGRLQTVK	DEG_APCC_DBOX_1	19:27	Mutation altering degron motif	0.6421
p.S17L	TCGA-B5-A1MR	UCEC	TCGA	ERGRLQTVK	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.2778
p.S17L	TCGA-EO-A3AV	UCEC	TCGA	ERGRLQTVK	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.2778
p.S17L	TCGA-EY-A1G8	UCEC	TCGA	ERGRLQTVK	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.2778
p.S17L	TCGA-F5-6814	READ	TCGA	ERGRLQTVK	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.2778
p.S17L	DO36556	READ	ICGC	ERGRLQTVK	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.2778
p.S17L	DO43578	UCEC	ICGC	ERGRLQTVK	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.2778
p.S17L	DO52412	UCEC	ICGC	ERGRLQTVK	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.2778
p.S17L	DO41758	UCEC	ICGC	ERGRLQTVK	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.2778
p.S17L	SIDM02015	Colorectal Carcinoma	GDSC	ERGRLQTVK	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.2778
p.T233I	TCGA-B5-A3FA	UCEC	TCGA	VTPTRS	DEG_SCF_FBW7_1	220:225	Mutation rewiring degron network	0.1111
p.T233I	DO52402	UCEC	ICGC	VTPTRS	DEG_SCF_FBW7_1	220:225	Mutation rewiring degron network	0.1111
p.A12T	TCGA-DF-A2KU	UCEC	TCGA	ERGRLQTVK	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.1389
p.A12T	DO223286	UCEC	ICGC	ERGRLQTVK	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.1389
p.Q13E	TCGA-FD-A3SO	BLCA	TCGA	ERGRLQTVK	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.1667
p.Q13E	DO569	BLCA	ICGC	ERGRLQTVK	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.1667
p.D218N	TCGA-J2-8192	LUAD	TCGA	VTPTRS	DEG_SCF_FBW7_1	220:225	Mutation rewiring degron network	0.2778
p.D218N	DO23806	LUAD	ICGC	VTPTRS	DEG_SCF_FBW7_1	220:225	Mutation rewiring degron network	0.2778
p.G217E	TCGA-K7-A5RG	LIHC	TCGA	VTPTRS	DEG_SCF_FBW7_1	220:225	Mutation rewiring degron network	0.25
p.G217E	DO52304	LIHC	ICGC	VTPTRS	DEG_SCF_FBW7_1	220:225	Mutation rewiring degron network	0.25
p.E232V	DO233709	GACA	ICGC	VTPTRS	DEG_SCF_FBW7_1	220:225	Mutation rewiring degron network	0.1389
p.Q219R	DO229248	THCA	ICGC	VTPTRS	DEG_SCF_FBW7_1	220:225	Mutation rewiring degron network	0.3056
p.M234T	SIDM01242	Melanoma	GDSC	VTPTRS	DEG_SCF_FBW7_1	220:225	Mutation rewiring degron network	0.0833
p.M234T	SIDM01471	Chronic Myelogenous Leukemia	GDSC	VTPTRS	DEG_SCF_FBW7_1	220:225	Mutation rewiring degron network	0.0833
p.M234T	SIDM00784	Glioma	GDSC	VTPTRS	DEG_SCF_FBW7_1	220:225	Mutation rewiring degron network	0.0833
p.M234T	SIDM01446	Glioblastoma	GDSC	VTPTRS	DEG_SCF_FBW7_1	220:225	Mutation rewiring degron network	0.0833
p.M234T	MMAC-SF	skin	COSMIC	VTPTRS	DEG_SCF_FBW7_1	220:225	Mutation rewiring degron network	0.0833
p.G21E	SIDM00917	Acute Myeloid Leukemia	GDSC	ERGRLQTVK	DEG_APCC_DBOX_1	19:27	Mutation altering degron motif	0.6087
p.G21E	ACH-002218	Leukemia	CCLE	ERGRLQTVK	DEG_APCC_DBOX_1	19:27	Mutation altering degron motif	0.6087
p.G21E	CESS	haematopoietic and lymphoid tissue	COSMIC	ERGRLQTVK	DEG_APCC_DBOX_1	19:27	Mutation altering degron motif	0.6087
p.R22Q	SIDM00999	Bladder Carcinoma	GDSC	ERGRLQTVK	DEG_APCC_DBOX_1	19:27	Mutation altering degron motif	0.6218
p.T235N	ACH-001134	Lymphoma	CCLE	VTPTRS	DEG_SCF_FBW7_1	220:225	Mutation rewiring degron network	0.0556
p.L226M	ACH-001786	Colon/Colorectal Cancer	CCLE	VTPTRS	DEG_SCF_FBW7_1	220:225	Mutation rewiring degron network	0.3056
p.M232T	MMAC-SF	skin	COSMIC	VTPTRS	DEG_SCF_FBW7_1	220:225	Mutation rewiring degron network	0.1389

Kaplan plot for ZNF445 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF445

UniProt ID: P59923

Entrez ID: 353274

Protein name: Zinc finger protein 445 (ZFP445) (Zinc finger protein 168) (Zinc finger protein with KRAB and SCAN domains 15)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF445 in