DegronMD

Uniprot ID: P59923

Source protein: Zinc finger protein 445

Source gene: ZNF445

Class: DEG_SCF_FBW7_1

Location: 220:225

E3 ligase: FBXW7

DEGRON score: 0.949

ASA_SCORE: 87.5667

COIL: 0.8113

CONS_SCORE: 0.1601

DSS_SCORE: 0.5668

HELIX: 0.0633

FCONS_SCORE: 0.4099

RIG_SCORE: 0.7411

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T233I	TCGA-B5-A3FA	UCEC	TCGA	VTPTRS	DEG_SCF_FBW7_1	0.1111
p.T233I	DO52402	UCEC	ICGC	VTPTRS	DEG_SCF_FBW7_1	0.1111
p.D218N	TCGA-J2-8192	LUAD	TCGA	VTPTRS	DEG_SCF_FBW7_1	0.2778
p.D218N	DO23806	LUAD	ICGC	VTPTRS	DEG_SCF_FBW7_1	0.2778
p.G217E	TCGA-K7-A5RG	LIHC	TCGA	VTPTRS	DEG_SCF_FBW7_1	0.25
p.G217E	DO52304	LIHC	ICGC	VTPTRS	DEG_SCF_FBW7_1	0.25
p.E232V	DO233709	GACA	ICGC	VTPTRS	DEG_SCF_FBW7_1	0.1389
p.Q219R	DO229248	THCA	ICGC	VTPTRS	DEG_SCF_FBW7_1	0.3056
p.M234T	SIDM01242	Melanoma	GDSC	VTPTRS	DEG_SCF_FBW7_1	0.0833
p.M234T	SIDM01471	Chronic Myelogenous Leukemia	GDSC	VTPTRS	DEG_SCF_FBW7_1	0.0833
p.M234T	SIDM00784	Glioma	GDSC	VTPTRS	DEG_SCF_FBW7_1	0.0833
p.M234T	SIDM01446	Glioblastoma	GDSC	VTPTRS	DEG_SCF_FBW7_1	0.0833
p.M234T	MMAC-SF	skin	COSMIC	VTPTRS	DEG_SCF_FBW7_1	0.0833
p.T235N	ACH-001134	Lymphoma	CCLE	VTPTRS	DEG_SCF_FBW7_1	0.0556
p.L226M	ACH-001786	Colon/Colorectal Cancer	CCLE	VTPTRS	DEG_SCF_FBW7_1	0.3056
p.M232T	MMAC-SF	skin	COSMIC	VTPTRS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P59923	Zinc finger protein 445	DEG_SCF_FBW7_1	220:225	VTPTRS	FBXW7	0.949	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons