DegronMD

Uniprot ID: Q9P2K1

Source protein: Coiled-coil and C2 domain-containing protein 2A

Source gene: CC2D2A

Class: DEG_APCC_DBOX_1

Location: 1179:1187

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7025

ASA_SCORE: 55.3889

COIL: 0.166

CONS_SCORE: 0.5966

DSS_SCORE: 0.0924

HELIX: 0.0093

FCONS_SCORE: 1.3557

RIG_SCORE: 0.8797

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I1178V	TCGA-BR-8361	STAD	TCGA	ERHWLGCVK	DEG_APCC_DBOX_1	0.3056
p.I1178V	DO48032	STAD	ICGC	ERHWLGCVK	DEG_APCC_DBOX_1	0.3056
p.F1195C	TCGA-EO-A22X	UCEC	TCGA	ERHWLGCVK	DEG_APCC_DBOX_1	0.1111
p.F1195C	DO43907	UCEC	ICGC	ERHWLGCVK	DEG_APCC_DBOX_1	0.1111
p.I1193T	DO231518	LINC	ICGC	ERHWLGCVK	DEG_APCC_DBOX_1	0.1667
p.Q1177R	DO52682	MALY	ICGC	ERHWLGCVK	DEG_APCC_DBOX_1	0.2778
p.T1192A	SIDM00789	Colorectal Carcinoma	GDSC	ERHWLGCVK	DEG_APCC_DBOX_1	0.1944
p.T1192A	ACH-000997	Colon/Colorectal Cancer	CCLE	ERHWLGCVK	DEG_APCC_DBOX_1	0.1944
p.T1192A	HCT-15	large_intestine	COSMIC	ERHWLGCVK	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2K1	Coiled-coil and C2 domain-containing protein 2A	DEG_APCC_DBOX_1	1179:1187	ERHWLGCVK	APC,CDC20,FZR1	0.7025	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons