DegronMD - Q9P2K1(CC2D2A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I1178V	TCGA-BR-8361	STAD	TCGA	ERHWLGCVK	DEG_APCC_DBOX_1	1179:1187	Mutation rewiring degron network	0.3056
p.I1178V	DO48032	STAD	ICGC	ERHWLGCVK	DEG_APCC_DBOX_1	1179:1187	Mutation rewiring degron network	0.3056
p.D1166E	TCGA-D6-6516	HNSC	TCGA	INIFDE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.1111
p.D1166E	DO15623	HNSC	ICGC	INIFDE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.1111
p.F1195C	TCGA-EO-A22X	UCEC	TCGA	ERHWLGCVK	DEG_APCC_DBOX_1	1179:1187	Mutation rewiring degron network	0.1111
p.F1195C	DO43907	UCEC	ICGC	ERHWLGCVK	DEG_APCC_DBOX_1	1179:1187	Mutation rewiring degron network	0.1111
p.D1166G	TCGA-FI-A2D5	UCEC	TCGA	INIFDE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.1111
p.D1166G	DO41331	UCEC	ICGC	INIFDE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.1111
p.D1167Y	TCGA-HZ-7918	PAAD	TCGA	INIFDE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.0833
p.D1167Y	DO229026	LICA	ICGC	INIFDE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.0833
p.D1167Y	DO32805	PAAD	ICGC	INIFDE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.0833
p.V1150F	DO229032	LICA	ICGC	INIFDE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.25
p.V1159I	DO229053	LICA	ICGC	INIFDE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.3056
p.V1159I	ACH-001130	Lymphoma	CCLE	INIFDE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.3056
p.I1193T	DO231518	LINC	ICGC	ERHWLGCVK	DEG_APCC_DBOX_1	1179:1187	Mutation rewiring degron network	0.1667
p.Q1177R	DO52682	MALY	ICGC	ERHWLGCVK	DEG_APCC_DBOX_1	1179:1187	Mutation rewiring degron network	0.2778
p.T1192A	SIDM00789	Colorectal Carcinoma	GDSC	ERHWLGCVK	DEG_APCC_DBOX_1	1179:1187	Mutation rewiring degron network	0.1944
p.T1192A	ACH-000997	Colon/Colorectal Cancer	CCLE	ERHWLGCVK	DEG_APCC_DBOX_1	1179:1187	Mutation rewiring degron network	0.1944
p.T1192A	HCT-15	large intestine	COSMIC	ERHWLGCVK	DEG_APCC_DBOX_1	1179:1187	Mutation rewiring degron network	0.1944
p.H1161Y	SIDM00282	Colorectal Carcinoma	GDSC	INIFDE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.25
p.H1161Y	ACH-000998	Colon/Colorectal Cancer	CCLE	INIFDE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.25
p.H1161Y	CW-2	large intestine	COSMIC	INIFDE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.25
p.R1168S	SIDM00282	Colorectal Carcinoma	GDSC	INIFDE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.0556
p.R1168S	ACH-000998	Colon/Colorectal Cancer	CCLE	INIFDE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.0556
p.R1168S	CW-2	large intestine	COSMIC	INIFDE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.0556
p.E1165K	ACH-001651	Endometrial/Uterine Cancer	CCLE	INIFDE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.1389

Kaplan plot for CC2D2A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CC2D2A

UniProt ID: Q9P2K1

Entrez ID: 57545

Protein name: Coiled-coil and C2 domain-containing protein 2A

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CC2D2A in