DegronMD

Uniprot ID: Q9P2K1

Source protein: Coiled-coil and C2 domain-containing protein 2A

Source gene: CC2D2A

Class: LIG_APCC_ABBA_1

Location: 1153:1158

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5954

ASA_SCORE: 24.4

COIL: 0.1528

CONS_SCORE: 0.6532

DSS_SCORE: 0.0534

HELIX: 0.0125

FCONS_SCORE: 1.5134

RIG_SCORE: 0.9161

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1166E	TCGA-D6-6516	HNSC	TCGA	INIFDE	LIG_APCC_ABBA_1	0.1111
p.D1166E	DO15623	HNSC	ICGC	INIFDE	LIG_APCC_ABBA_1	0.1111
p.D1166G	TCGA-FI-A2D5	UCEC	TCGA	INIFDE	LIG_APCC_ABBA_1	0.1111
p.D1166G	DO41331	UCEC	ICGC	INIFDE	LIG_APCC_ABBA_1	0.1111
p.D1167Y	TCGA-HZ-7918	PAAD	TCGA	INIFDE	LIG_APCC_ABBA_1	0.0833
p.D1167Y	DO229026	LICA	ICGC	INIFDE	LIG_APCC_ABBA_1	0.0833
p.D1167Y	DO32805	PAAD	ICGC	INIFDE	LIG_APCC_ABBA_1	0.0833
p.V1150F	DO229032	LICA	ICGC	INIFDE	LIG_APCC_ABBA_1	0.25
p.V1159I	DO229053	LICA	ICGC	INIFDE	LIG_APCC_ABBA_1	0.3056
p.V1159I	ACH-001130	Lymphoma	CCLE	INIFDE	LIG_APCC_ABBA_1	0.3056
p.H1161Y	SIDM00282	Colorectal Carcinoma	GDSC	INIFDE	LIG_APCC_ABBA_1	0.25
p.H1161Y	ACH-000998	Colon/Colorectal Cancer	CCLE	INIFDE	LIG_APCC_ABBA_1	0.25
p.H1161Y	CW-2	large_intestine	COSMIC	INIFDE	LIG_APCC_ABBA_1	0.25
p.R1168S	SIDM00282	Colorectal Carcinoma	GDSC	INIFDE	LIG_APCC_ABBA_1	0.0556
p.R1168S	ACH-000998	Colon/Colorectal Cancer	CCLE	INIFDE	LIG_APCC_ABBA_1	0.0556
p.R1168S	CW-2	large_intestine	COSMIC	INIFDE	LIG_APCC_ABBA_1	0.0556
p.E1165K	ACH-001651	Endometrial/Uterine Cancer	CCLE	INIFDE	LIG_APCC_ABBA_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2K1	Coiled-coil and C2 domain-containing protein 2A	LIG_APCC_ABBA_1	1153:1158	INIFDE	APC,CDC20,FZR1	0.5954	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons