DegronMD

Uniprot ID: P21675

Source protein: Transcription initiation factor TFIID subunit 1

Source gene: TAF1

Class: DEG_APCC_DBOX_1

Location: 1125:1133

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9608

ASA_SCORE: 110.3889

COIL: 0.1168

CONS_SCORE: 0.3717

DSS_SCORE: 0.6149

HELIX: 0.8859

FCONS_SCORE: 1.4023

RIG_SCORE: 0.7701

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M1128L	TCGA-23-2643	OV	TCGA	ERKELQRML	DEG_APCC_DBOX_1	0.711
p.M1128L	DO28008	OV	ICGC	ERKELQRML	DEG_APCC_DBOX_1	0.711
p.S1139L	TCGA-50-6594	LUAD	TCGA	ERKELQRML	DEG_APCC_DBOX_1	0.1667
p.S1139L	DO24275	LUAD	ICGC	ERKELQRML	DEG_APCC_DBOX_1	0.1667
p.Q1137K	TCGA-5L-AAT1	BRCA	TCGA	ERKELQRML	DEG_APCC_DBOX_1	0.2222
p.Q1137K	DO219594	BRCA	ICGC	ERKELQRML	DEG_APCC_DBOX_1	0.2222
p.K1132E	TCGA-CV-7248	HNSC	TCGA	ERKELQRML	DEG_APCC_DBOX_1	0.7022
p.K1132E	DO14806	HNSC	ICGC	ERKELQRML	DEG_APCC_DBOX_1	0.7022
p.S1135N	TCGA-EC-A24G	UCEC	TCGA	ERKELQRML	DEG_APCC_DBOX_1	0.2778
p.S1135N	DO40996	UCEC	ICGC	ERKELQRML	DEG_APCC_DBOX_1	0.2778
p.M1121I	TCGA-EE-A2M8	SKCM	TCGA	ERKELQRML	DEG_APCC_DBOX_1	0.2222
p.M1121I	DO38075	SKCM	ICGC	ERKELQRML	DEG_APCC_DBOX_1	0.2222
p.G1122R	TCGA-EO-A22R	UCEC	TCGA	ERKELQRML	DEG_APCC_DBOX_1	0.25
p.G1122R	DO42713	UCEC	ICGC	ERKELQRML	DEG_APCC_DBOX_1	0.25
p.E1126D	TCGA-EO-A22R	UCEC	TCGA	ERKELQRML	DEG_APCC_DBOX_1	0.6758
p.E1126D	DO42713	UCEC	ICGC	ERKELQRML	DEG_APCC_DBOX_1	0.6758
p.R1142L	DO229022	LICA	ICGC	ERKELQRML	DEG_APCC_DBOX_1	0.0833
p.M1128V	DO231736	LINC	ICGC	ERKELQRML	DEG_APCC_DBOX_1	0.7208
p.R1142W	DO231353	THCA	ICGC	ERKELQRML	DEG_APCC_DBOX_1	0.0833
p.M1121T	SIDM01169	Ovarian Carcinoma	GDSC	ERKELQRML	DEG_APCC_DBOX_1	0.2222
p.M1121T	ACH-000885	Ovarian Cancer	CCLE	ERKELQRML	DEG_APCC_DBOX_1	0.2222
p.M1121T	TOV-21G	ovary	COSMIC	ERKELQRML	DEG_APCC_DBOX_1	0.2222
p.E1120A	SIDM00803	Kidney Carcinoma	GDSC	ERKELQRML	DEG_APCC_DBOX_1	0.1944
p.E1120A	ACH-000411	Kidney Cancer	CCLE	ERKELQRML	DEG_APCC_DBOX_1	0.1944
p.E1120A	769-P	kidney	COSMIC	ERKELQRML	DEG_APCC_DBOX_1	0.1944
p.E1126A	SIDM01611	Endometrial Carcinoma	GDSC	ERKELQRML	DEG_APCC_DBOX_1	0.7701
p.E1126A	ACH-000996	Endometrial/Uterine Cancer	CCLE	ERKELQRML	DEG_APCC_DBOX_1	0.7701
p.A1136T	ACH-000977	lymph_node	CCLE	ERKELQRML	DEG_APCC_DBOX_1	0.25
p.A1136T	LNCaP-Clone-FGC	prostate	COSMIC	ERKELQRML	DEG_APCC_DBOX_1	0.25

Drug responses associated with TAF1 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.L81F (No)	GDSC	TAF1_5496	18.997
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.L417I (No)	GDSC	TAF1_5496	18.997
SIDM01228	SKCM\|melanoma	p.A83T (No)	GDSC	TAF1_5496	9.6844
SIDM00729	LUAD\|lung_NSCLC_adenocarcinoma	p.D1170G (No)	GDSC	TAF1_5496	103.77
SIDM00951	LAML\|acute_myeloid_leukaemia	p.P808T (No)	GDSC	TAF1_5496	15.964
SIDM00826	COREAD\|large_intestine	p.I235V (No)	GDSC	TAF1_5496	24.373
SIDM00588	HNSC\|head_and_neck	p.D330N (No)	GDSC	TAF1_5496	0.403
SIDM01086	ALL\|leukemia	p.D1168G (No)	GDSC	TAF1_5496	3.5811
SIDM00121	ALL\|lymphoblastic_leukemia	p.G4S (No)	GDSC	TAF1_5496	18.005
SIDM00683	PRAD\|prostate	p.S340P (No)	GDSC	TAF1_5496	20.308
SIDM00683	PRAD\|prostate	p.W882R (No)	GDSC	TAF1_5496	20.308
SIDM00683	PRAD\|prostate	p.M1679L (No)	GDSC	TAF1_5496	20.308
SIDM00351	HNSC\|head_and_neck	p.D1048H (No)	GDSC	TAF1_5496	54.05
SIDM01007	ALL\|lymphoblastic_leukemia	p.R1089H (No)	GDSC	TAF1_5496	7.7043
SIDM00781	COREAD\|large_intestine	p.R1018C (No)	GDSC	TAF1_5496	145.21
SIDM00781	COREAD\|large_intestine	p.R1217H (No)	GDSC	TAF1_5496	145.21
SIDM00146	BRCA\|breast	p.N767K (No)	GDSC	TAF1_5496	22.62
SIDM01174	CESC\|cervix	p.Q126H (No)	GDSC	TAF1_5496	9.7797
SIDM00686	UCEC\|endometrium	p.G680V (No)	GDSC	TAF1_5496	245.55
SIDM00251	STAD\|stomach	p.R1511H (No)	GDSC	TAF1_5496	5.7577
SIDM00214	COREAD\|large_intestine	p.C1288R (No)	GDSC	TAF1_5496	55.815
SIDM00003	SKCM\|melanoma	p.S1676F (No)	GDSC	TAF1_5496	137.28
SIDM01106	SKCM\|melanoma	p.S650F (No)	GDSC	TAF1_5496	151.51
SIDM00675	BRCA\|breast	p.R1692Q (No)	GDSC	TAF1_5496	328.79
SIDM00945	COREAD\|large_intestine	p.A1527V (No)	GDSC	TAF1_5496	63.064
SIDM01043	UNCLASSIFIED\|endometrium	p.K168N (No)	GDSC	TAF1_5496	121
SIDM01043	UNCLASSIFIED\|endometrium	p.R864Q (No)	GDSC	TAF1_5496	121
SIDM00151	OV\|ovary	p.E55fs*23 (No)	GDSC	TAF1_5496	89.27
SIDM00151	OV\|ovary	p.K667fs*4 (No)	GDSC	TAF1_5496	89.27
SIDM00618	LIHC\|liver	p.D1521Y (No)	GDSC	TAF1_5496	1.9392
SIDM01108	LUAD\|lung_NSCLC_adenocarcinoma	p.E298_V299insE (No)	GDSC	TAF1_5496	1185.3
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.T11I (No)	GDSC	TAF1_5496	93.657
SIDM01045	UCEC\|endometrium	p.Q829R (No)	GDSC	TAF1_5496	85.558
SIDM00211	ALL\|lymphoblastic_leukemia	p.R288H (No)	GDSC	TAF1_5496	10.095
SIDM00217	COREAD\|large_intestine	p.R1190H (No)	GDSC	TAF1_5496	52.812
SIDM00807	BLCA\|bladder	p.A318G (No)	GDSC	TAF1_5496	129.1
SIDM00933	BRCA\|breast	p.C326R (No)	GDSC	TAF1_5496	35.504
SIDM00933	BRCA\|breast	p.A1024T (No)	GDSC	TAF1_5496	35.504
SIDM01042	BRCA\|breast	p.E703Q (No)	GDSC	TAF1_5496	14.521
SIDM01042	BRCA\|breast	p.S1042C (No)	GDSC	TAF1_5496	14.521
SIDM00596	UCEC\|endometrium	p.E706K (No)	GDSC	TAF1_5496	7.9859
SIDM00282	COREAD\|large_intestine	p.H663Y (No)	GDSC	TAF1_5496	13.83
SIDM00282	COREAD\|large_intestine	p.K1030N (No)	GDSC	TAF1_5496	13.83
SIDM00282	COREAD\|large_intestine	p.E1735A (No)	GDSC	TAF1_5496	13.83
SIDM01176	ALL\|lymphoblastic_leukemia	p.G68D (No)	GDSC	TAF1_5496	29.131
SIDM00879	BRCA\|breast	p.T11I (No)	GDSC	TAF1_5496	6.1824
SIDM01206	NB\|neuroblastoma	p.S1740Y (No)	GDSC	TAF1_5496	16.151
SIDM00695	SKCM\|melanoma	p.M1540I (No)	GDSC	TAF1_5496	51.445
SIDM01245	ALL\|lymphoblastic_leukemia	p.N181H (No)	GDSC	TAF1_5496	49.449
SIDM00954	BRCA\|breast	p.A318G (No)	GDSC	TAF1_5496	18.289
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.A318G (No)	GDSC	TAF1_5496	24.151
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.N181D (No)	GDSC	TAF1_5496	110.67
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.K667fs*4 (No)	GDSC	TAF1_5496	87.056
SIDM01090	COREAD\|large_intestine	p.K667fs*4 (No)	GDSC	TAF1_5496	21.182
SIDM01169	OV\|ovary	p.M1121T (Yes)	GDSC	TAF1_5496	259.18
SIDM01008	DLBC\|B_cell_lymphoma	p.Y986D (No)	GDSC	TAF1_5496	24.617
SIDM00585	LIHC\|liver	p.G184V (No)	GDSC	TAF1_5496	0.944
SIDM00585	LIHC\|liver	p.G1706E (No)	GDSC	TAF1_5496	0.944
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.K667fs*4 (No)	GDSC	TAF1_5496	14.805
SIDM00803	KIRC\|kidney	p.E1120A (Yes)	GDSC	TAF1_5496	183.23
SIDM00606	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.R1018H (No)	GDSC	TAF1_5496	8.7136
SIDM01060	SKCM\|melanoma	p.P459L (No)	GDSC	TAF1_5496	59.546
SIDM00813	UNCLASSIFIED\|Hodgkin_lymphoma	p.E298_V299insE (No)	GDSC	TAF1_5496	76.301
SIDM00537	COREAD\|large_intestine	p.T355A (No)	GDSC	TAF1_5496	26.19
SIDM00537	COREAD\|large_intestine	p.Q1057* (No)	GDSC	TAF1_5496	26.19
SIDM00537	COREAD\|large_intestine	p.N1594D (No)	GDSC	TAF1_5496	26.19
SIDM01146	STAD\|stomach	p.A466V (No)	GDSC	TAF1_5496	14.896
SIDM00799	GBM\|glioma	p.P215L (No)	GDSC	TAF1_5496	130.61
SIDM00238	OV\|ovary	p.D1669V (No)	GDSC	TAF1_5496	2.9738
SIDM00571	UNCLASSIFIED\|pancreas	p.R1029H (No)	GDSC	TAF1_5496	318.34

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ERKELQRML

Degron related mutations and impact score

Drug responses associated with TAF1 mutations

All proteins holding degron of ERKELQRML

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P21675	Transcription initiation factor TFIID subunit 1	DEG_APCC_DBOX_1	1125:1133	ERKELQRML	APC,CDC20,FZR1	0.9608	More...