DegronMD - P21675(TAF1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.C1300W	TCGA-21-5782	LUSC	TCGA	KTVIHND	LIG_APCC_ABBAyCdc20_2	1305:1311	Mutation rewiring degron network	0.1944
p.C1300W	DO27120	LUSC	ICGC	KTVIHND	LIG_APCC_ABBAyCdc20_2	1305:1311	Mutation rewiring degron network	0.1944
p.M1128L	TCGA-23-2643	OV	TCGA	ERKELQRML	DEG_APCC_DBOX_1	1125:1133	Mutation altering degron motif	0.711
p.M1128L	DO28008	OV	ICGC	ERKELQRML	DEG_APCC_DBOX_1	1125:1133	Mutation altering degron motif	0.711
p.S1139L	TCGA-50-6594	LUAD	TCGA	ERKELQRML	DEG_APCC_DBOX_1	1125:1133	Mutation rewiring degron network	0.1667
p.S1139L	DO24275	LUAD	ICGC	ERKELQRML	DEG_APCC_DBOX_1	1125:1133	Mutation rewiring degron network	0.1667
p.Q1137K	TCGA-5L-AAT1	BRCA	TCGA	ERKELQRML	DEG_APCC_DBOX_1	1125:1133	Mutation rewiring degron network	0.2222
p.Q1137K	DO219594	BRCA	ICGC	ERKELQRML	DEG_APCC_DBOX_1	1125:1133	Mutation rewiring degron network	0.2222
p.A1308V	TCGA-AX-A1CE	UCEC	TCGA	KTVIHND	LIG_APCC_ABBAyCdc20_2	1305:1311	Mutation altering degron motif	0.6936
p.A1308V	TCGA-AX-A3G8	UCEC	TCGA	KTVIHND	LIG_APCC_ABBAyCdc20_2	1305:1311	Mutation altering degron motif	0.6936
p.A1308V	DO46591	OV	ICGC	KTVIHND	LIG_APCC_ABBAyCdc20_2	1305:1311	Mutation altering degron motif	0.6936
p.A1308V	DO41014	UCEC	ICGC	KTVIHND	LIG_APCC_ABBAyCdc20_2	1305:1311	Mutation altering degron motif	0.6936
p.A1308V	DO42280	UCEC	ICGC	KTVIHND	LIG_APCC_ABBAyCdc20_2	1305:1311	Mutation altering degron motif	0.6936
p.K1132E	TCGA-CV-7248	HNSC	TCGA	ERKELQRML	DEG_APCC_DBOX_1	1125:1133	Mutation altering degron motif	0.7022
p.K1132E	DO14806	HNSC	ICGC	ERKELQRML	DEG_APCC_DBOX_1	1125:1133	Mutation altering degron motif	0.7022
p.S1135N	TCGA-EC-A24G	UCEC	TCGA	ERKELQRML	DEG_APCC_DBOX_1	1125:1133	Mutation rewiring degron network	0.2778
p.S1135N	DO40996	UCEC	ICGC	ERKELQRML	DEG_APCC_DBOX_1	1125:1133	Mutation rewiring degron network	0.2778
p.M1121I	TCGA-EE-A2M8	SKCM	TCGA	ERKELQRML	DEG_APCC_DBOX_1	1125:1133	Mutation rewiring degron network	0.2222
p.M1121I	DO38075	SKCM	ICGC	ERKELQRML	DEG_APCC_DBOX_1	1125:1133	Mutation rewiring degron network	0.2222
p.G1122R	TCGA-EO-A22R	UCEC	TCGA	ERKELQRML	DEG_APCC_DBOX_1	1125:1133	Mutation rewiring degron network	0.25
p.G1122R	DO42713	UCEC	ICGC	ERKELQRML	DEG_APCC_DBOX_1	1125:1133	Mutation rewiring degron network	0.25
p.E1126D	TCGA-EO-A22R	UCEC	TCGA	ERKELQRML	DEG_APCC_DBOX_1	1125:1133	Mutation altering degron motif	0.6758
p.E1126D	DO42713	UCEC	ICGC	ERKELQRML	DEG_APCC_DBOX_1	1125:1133	Mutation altering degron motif	0.6758
p.Y1303C	TCGA-XF-AAN7	BLCA	TCGA	KTVIHND	LIG_APCC_ABBAyCdc20_2	1305:1311	Mutation rewiring degron network	0.2778
p.Y1303C	DO51946	BLCA	ICGC	KTVIHND	LIG_APCC_ABBAyCdc20_2	1305:1311	Mutation rewiring degron network	0.2778
p.C1300R	DO225007	BRCA	ICGC	KTVIHND	LIG_APCC_ABBAyCdc20_2	1305:1311	Mutation rewiring degron network	0.1944
p.F1299L	DO228696	EOPC	ICGC	KTVIHND	LIG_APCC_ABBAyCdc20_2	1305:1311	Mutation rewiring degron network	0.1667
p.R1142L	DO229022	LICA	ICGC	ERKELQRML	DEG_APCC_DBOX_1	1125:1133	Mutation rewiring degron network	0.0833
p.M1128V	DO231736	LINC	ICGC	ERKELQRML	DEG_APCC_DBOX_1	1125:1133	Mutation altering degron motif	0.7208
p.A1308G	DO34921	PACA	ICGC	KTVIHND	LIG_APCC_ABBAyCdc20_2	1305:1311	Mutation altering degron motif	0.754
p.R1295T	DO227891	PBCA	ICGC	KTVIHND	LIG_APCC_ABBAyCdc20_2	1305:1311	Mutation rewiring degron network	0.0556
p.R1142W	DO231353	THCA	ICGC	ERKELQRML	DEG_APCC_DBOX_1	1125:1133	Mutation rewiring degron network	0.0833
p.M1121T	SIDM01169	Ovarian Carcinoma	GDSC	ERKELQRML	DEG_APCC_DBOX_1	1125:1133	Mutation rewiring degron network	0.2222
p.M1121T	ACH-000885	Ovarian Cancer	CCLE	ERKELQRML	DEG_APCC_DBOX_1	1125:1133	Mutation rewiring degron network	0.2222
p.M1121T	TOV-21G	ovary	COSMIC	ERKELQRML	DEG_APCC_DBOX_1	1125:1133	Mutation rewiring degron network	0.2222
p.E1120A	SIDM00803	Kidney Carcinoma	GDSC	ERKELQRML	DEG_APCC_DBOX_1	1125:1133	Mutation rewiring degron network	0.1944
p.E1120A	ACH-000411	Kidney Cancer	CCLE	ERKELQRML	DEG_APCC_DBOX_1	1125:1133	Mutation rewiring degron network	0.1944
p.E1120A	769-P	kidney	COSMIC	ERKELQRML	DEG_APCC_DBOX_1	1125:1133	Mutation rewiring degron network	0.1944
p.E1126A	SIDM01611	Endometrial Carcinoma	GDSC	ERKELQRML	DEG_APCC_DBOX_1	1125:1133	Mutation altering degron motif	0.7701
p.E1126A	ACH-000996	Endometrial/Uterine Cancer	CCLE	ERKELQRML	DEG_APCC_DBOX_1	1125:1133	Mutation altering degron motif	0.7701
p.Q1299H	ACH-000928	Endometrial/Uterine Cancer	CCLE	KTVIHND	LIG_APCC_ABBAyCdc20_2	1305:1311	Mutation rewiring degron network	0.1667
p.A1136T	ACH-000977	lymph node	CCLE	ERKELQRML	DEG_APCC_DBOX_1	1125:1133	Mutation rewiring degron network	0.25
p.A1136T	LNCaP-Clone-FGC	prostate	COSMIC	ERKELQRML	DEG_APCC_DBOX_1	1125:1133	Mutation rewiring degron network	0.25

Kaplan plot for TAF1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TAF1

UniProt ID: P21675

Entrez ID: 6872

Protein name: Transcription initiation factor TFIID subunit 1 (EC 2.3.1.48) (EC 2.7.11.1) (Cell cycle gene 1 protein) (TBP-associated factor 250 kDa) (p250) (Transcription initiation factor TFIID 250 kDa subunit) (TAF(II)250) (TAFII-250) (TAFII250)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for TAF1 in