DegronMD

Uniprot ID: P21675

Source protein: Transcription initiation factor TFIID subunit 1

Source gene: TAF1

Class: LIG_APCC_ABBAyCdc20_2

Location: 1305:1311

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5137

ASA_SCORE: 85.1

COIL: 0.5681

CONS_SCORE: 0.2355

DSS_SCORE: 0.4899

HELIX: 0.3754

FCONS_SCORE: 0.7977

RIG_SCORE: 0.79

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C1300W	TCGA-21-5782	LUSC	TCGA	KTVIHND	LIG_APCC_ABBAyCdc20_2	0.1944
p.C1300W	DO27120	LUSC	ICGC	KTVIHND	LIG_APCC_ABBAyCdc20_2	0.1944
p.A1308V	TCGA-AX-A1CE	UCEC	TCGA	KTVIHND	LIG_APCC_ABBAyCdc20_2	0.6936
p.A1308V	TCGA-AX-A3G8	UCEC	TCGA	KTVIHND	LIG_APCC_ABBAyCdc20_2	0.6936
p.A1308V	DO46591	OV	ICGC	KTVIHND	LIG_APCC_ABBAyCdc20_2	0.6936
p.A1308V	DO41014	UCEC	ICGC	KTVIHND	LIG_APCC_ABBAyCdc20_2	0.6936
p.A1308V	DO42280	UCEC	ICGC	KTVIHND	LIG_APCC_ABBAyCdc20_2	0.6936
p.Y1303C	TCGA-XF-AAN7	BLCA	TCGA	KTVIHND	LIG_APCC_ABBAyCdc20_2	0.2778
p.Y1303C	DO51946	BLCA	ICGC	KTVIHND	LIG_APCC_ABBAyCdc20_2	0.2778
p.C1300R	DO225007	BRCA	ICGC	KTVIHND	LIG_APCC_ABBAyCdc20_2	0.1944
p.F1299L	DO228696	EOPC	ICGC	KTVIHND	LIG_APCC_ABBAyCdc20_2	0.1667
p.A1308G	DO34921	PACA	ICGC	KTVIHND	LIG_APCC_ABBAyCdc20_2	0.754
p.R1295T	DO227891	PBCA	ICGC	KTVIHND	LIG_APCC_ABBAyCdc20_2	0.0556
p.Q1299H	ACH-000928	Endometrial/Uterine Cancer	CCLE	KTVIHND	LIG_APCC_ABBAyCdc20_2	0.1667

Drug responses associated with TAF1 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.L81F (No)	GDSC	TAF1_5496	18.997
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.L417I (No)	GDSC	TAF1_5496	18.997
SIDM01228	SKCM\|melanoma	p.A83T (No)	GDSC	TAF1_5496	9.6844
SIDM00729	LUAD\|lung_NSCLC_adenocarcinoma	p.D1170G (No)	GDSC	TAF1_5496	103.77
SIDM00951	LAML\|acute_myeloid_leukaemia	p.P808T (No)	GDSC	TAF1_5496	15.964
SIDM00826	COREAD\|large_intestine	p.I235V (No)	GDSC	TAF1_5496	24.373
SIDM00588	HNSC\|head_and_neck	p.D330N (No)	GDSC	TAF1_5496	0.403
SIDM01086	ALL\|leukemia	p.D1168G (No)	GDSC	TAF1_5496	3.5811
SIDM00121	ALL\|lymphoblastic_leukemia	p.G4S (No)	GDSC	TAF1_5496	18.005
SIDM00683	PRAD\|prostate	p.S340P (No)	GDSC	TAF1_5496	20.308
SIDM00683	PRAD\|prostate	p.W882R (No)	GDSC	TAF1_5496	20.308
SIDM00683	PRAD\|prostate	p.M1679L (No)	GDSC	TAF1_5496	20.308
SIDM00351	HNSC\|head_and_neck	p.D1048H (No)	GDSC	TAF1_5496	54.05
SIDM01007	ALL\|lymphoblastic_leukemia	p.R1089H (No)	GDSC	TAF1_5496	7.7043
SIDM00781	COREAD\|large_intestine	p.R1018C (No)	GDSC	TAF1_5496	145.21
SIDM00781	COREAD\|large_intestine	p.R1217H (No)	GDSC	TAF1_5496	145.21
SIDM00146	BRCA\|breast	p.N767K (No)	GDSC	TAF1_5496	22.62
SIDM01174	CESC\|cervix	p.Q126H (No)	GDSC	TAF1_5496	9.7797
SIDM00686	UCEC\|endometrium	p.G680V (No)	GDSC	TAF1_5496	245.55
SIDM00251	STAD\|stomach	p.R1511H (No)	GDSC	TAF1_5496	5.7577
SIDM00214	COREAD\|large_intestine	p.C1288R (No)	GDSC	TAF1_5496	55.815
SIDM00003	SKCM\|melanoma	p.S1676F (No)	GDSC	TAF1_5496	137.28
SIDM01106	SKCM\|melanoma	p.S650F (No)	GDSC	TAF1_5496	151.51
SIDM00675	BRCA\|breast	p.R1692Q (No)	GDSC	TAF1_5496	328.79
SIDM00945	COREAD\|large_intestine	p.A1527V (No)	GDSC	TAF1_5496	63.064
SIDM01043	UNCLASSIFIED\|endometrium	p.K168N (No)	GDSC	TAF1_5496	121
SIDM01043	UNCLASSIFIED\|endometrium	p.R864Q (No)	GDSC	TAF1_5496	121
SIDM00151	OV\|ovary	p.E55fs*23 (No)	GDSC	TAF1_5496	89.27
SIDM00151	OV\|ovary	p.K667fs*4 (No)	GDSC	TAF1_5496	89.27
SIDM00618	LIHC\|liver	p.D1521Y (No)	GDSC	TAF1_5496	1.9392
SIDM01108	LUAD\|lung_NSCLC_adenocarcinoma	p.E298_V299insE (No)	GDSC	TAF1_5496	1185.3
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.T11I (No)	GDSC	TAF1_5496	93.657
SIDM01045	UCEC\|endometrium	p.Q829R (No)	GDSC	TAF1_5496	85.558
SIDM00211	ALL\|lymphoblastic_leukemia	p.R288H (No)	GDSC	TAF1_5496	10.095
SIDM00217	COREAD\|large_intestine	p.R1190H (No)	GDSC	TAF1_5496	52.812
SIDM00807	BLCA\|bladder	p.A318G (No)	GDSC	TAF1_5496	129.1
SIDM00933	BRCA\|breast	p.C326R (No)	GDSC	TAF1_5496	35.504
SIDM00933	BRCA\|breast	p.A1024T (No)	GDSC	TAF1_5496	35.504
SIDM01042	BRCA\|breast	p.E703Q (No)	GDSC	TAF1_5496	14.521
SIDM01042	BRCA\|breast	p.S1042C (No)	GDSC	TAF1_5496	14.521
SIDM00596	UCEC\|endometrium	p.E706K (No)	GDSC	TAF1_5496	7.9859
SIDM00282	COREAD\|large_intestine	p.H663Y (No)	GDSC	TAF1_5496	13.83
SIDM00282	COREAD\|large_intestine	p.K1030N (No)	GDSC	TAF1_5496	13.83
SIDM00282	COREAD\|large_intestine	p.E1735A (No)	GDSC	TAF1_5496	13.83
SIDM01176	ALL\|lymphoblastic_leukemia	p.G68D (No)	GDSC	TAF1_5496	29.131
SIDM00879	BRCA\|breast	p.T11I (No)	GDSC	TAF1_5496	6.1824
SIDM01206	NB\|neuroblastoma	p.S1740Y (No)	GDSC	TAF1_5496	16.151
SIDM00695	SKCM\|melanoma	p.M1540I (No)	GDSC	TAF1_5496	51.445
SIDM01245	ALL\|lymphoblastic_leukemia	p.N181H (No)	GDSC	TAF1_5496	49.449
SIDM00954	BRCA\|breast	p.A318G (No)	GDSC	TAF1_5496	18.289
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.A318G (No)	GDSC	TAF1_5496	24.151
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.N181D (No)	GDSC	TAF1_5496	110.67
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.K667fs*4 (No)	GDSC	TAF1_5496	87.056
SIDM01090	COREAD\|large_intestine	p.K667fs*4 (No)	GDSC	TAF1_5496	21.182
SIDM01169	OV\|ovary	p.M1121T (No)	GDSC	TAF1_5496	259.18
SIDM01008	DLBC\|B_cell_lymphoma	p.Y986D (No)	GDSC	TAF1_5496	24.617
SIDM00585	LIHC\|liver	p.G184V (No)	GDSC	TAF1_5496	0.944
SIDM00585	LIHC\|liver	p.G1706E (No)	GDSC	TAF1_5496	0.944
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.K667fs*4 (No)	GDSC	TAF1_5496	14.805
SIDM00803	KIRC\|kidney	p.E1120A (No)	GDSC	TAF1_5496	183.23
SIDM00606	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.R1018H (No)	GDSC	TAF1_5496	8.7136
SIDM01060	SKCM\|melanoma	p.P459L (No)	GDSC	TAF1_5496	59.546
SIDM00813	UNCLASSIFIED\|Hodgkin_lymphoma	p.E298_V299insE (No)	GDSC	TAF1_5496	76.301
SIDM00537	COREAD\|large_intestine	p.T355A (No)	GDSC	TAF1_5496	26.19
SIDM00537	COREAD\|large_intestine	p.Q1057* (No)	GDSC	TAF1_5496	26.19
SIDM00537	COREAD\|large_intestine	p.N1594D (No)	GDSC	TAF1_5496	26.19
SIDM01146	STAD\|stomach	p.A466V (No)	GDSC	TAF1_5496	14.896
SIDM00799	GBM\|glioma	p.P215L (No)	GDSC	TAF1_5496	130.61
SIDM00238	OV\|ovary	p.D1669V (No)	GDSC	TAF1_5496	2.9738
SIDM00571	UNCLASSIFIED\|pancreas	p.R1029H (No)	GDSC	TAF1_5496	318.34

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KTVIHND

Degron related mutations and impact score

Drug responses associated with TAF1 mutations

All proteins holding degron of KTVIHND

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P21675	Transcription initiation factor TFIID subunit 1	LIG_APCC_ABBAyCdc20_2	1305:1311	KTVIHND	APC,CDC20,FZR1	0.5137	More...