DegronMD

Uniprot ID: Q8IZX4

Source protein: Transcription initiation factor TFIID subunit 1-like

Source gene: TAF1L

Class: DEG_APCC_DBOX_1

Location: 1144:1152

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6815

ASA_SCORE: 101.7111

COIL: 0.1179

CONS_SCORE: 0.4144

DSS_SCORE: 0.4484

HELIX: 0.8829

FCONS_SCORE: 1.3538

RIG_SCORE: 0.8162

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1145W	TCGA-22-1012	LUSC	TCGA	ERKELRRML	DEG_APCC_DBOX_1	0.8634
p.R1145W	DO233216	GACA	ICGC	ERKELRRML	DEG_APCC_DBOX_1	0.8634
p.R1145W	DO27302	LUSC	ICGC	ERKELRRML	DEG_APCC_DBOX_1	0.8634
p.Q1135E	TCGA-22-5473	LUSC	TCGA	ERKELRRML	DEG_APCC_DBOX_1	0.0833
p.Q1135E	TCGA-A1-A0SI	BRCA	TCGA	ERKELRRML	DEG_APCC_DBOX_1	0.0833
p.Q1135E	TCGA-UC-A7PF	CESC	TCGA	ERKELRRML	DEG_APCC_DBOX_1	0.0833
p.Q1135E	DO1774	BRCA	ICGC	ERKELRRML	DEG_APCC_DBOX_1	0.0833
p.Q1135E	DO49987	CESC	ICGC	ERKELRRML	DEG_APCC_DBOX_1	0.0833
p.Q1135E	DO26467	LUSC	ICGC	ERKELRRML	DEG_APCC_DBOX_1	0.0833
p.L1148V	TCGA-24-1846	OV	TCGA	ERKELRRML	DEG_APCC_DBOX_1	0.6765
p.L1148V	DO32718	OV	ICGC	ERKELRRML	DEG_APCC_DBOX_1	0.6765
p.S1157L	TCGA-4E-A92E	UCEC	TCGA	ERKELRRML	DEG_APCC_DBOX_1	0.1944
p.S1157L	DO223277	UCEC	ICGC	ERKELRRML	DEG_APCC_DBOX_1	0.1944
p.R1138C	TCGA-AN-A046	BRCA	TCGA	ERKELRRML	DEG_APCC_DBOX_1	0.1667
p.R1138C	DO1285	BRCA	ICGC	ERKELRRML	DEG_APCC_DBOX_1	0.1667
p.G1161R	TCGA-HC-A48F	PRAD	TCGA	ERKELRRML	DEG_APCC_DBOX_1	0.0833
p.G1161R	DO46800	PRAD	ICGC	ERKELRRML	DEG_APCC_DBOX_1	0.0833
p.R1149Q	TCGA-MN-A4N4	LUAD	TCGA	ERKELRRML	DEG_APCC_DBOX_1	0.6218
p.R1149Q	DO26250	LUAD	ICGC	ERKELRRML	DEG_APCC_DBOX_1	0.6218
p.L1136M	DO222765	COCA	ICGC	ERKELRRML	DEG_APCC_DBOX_1	0.1111
p.W1140R	DO229512	LAML	ICGC	ERKELRRML	DEG_APCC_DBOX_1	0.2222
p.R1145Q	DO35614	PBCA	ICGC	ERKELRRML	DEG_APCC_DBOX_1	0.7329
p.R1149W	DO232761	PBCA	ICGC	ERKELRRML	DEG_APCC_DBOX_1	0.7523
p.R1138S	SIDM00562	Breast Carcinoma	GDSC	ERKELRRML	DEG_APCC_DBOX_1	0.1667
p.R1138S	ACH-002065	Sarcoma	CCLE	ERKELRRML	DEG_APCC_DBOX_1	0.1667
p.R1138S	ACH-002163	Breast Cancer	CCLE	ERKELRRML	DEG_APCC_DBOX_1	0.1667
p.R1138S	MRK-nu-1	breast	COSMIC	ERKELRRML	DEG_APCC_DBOX_1	0.1667
p.G1156D	SIDM00365	Small Cell Lung Carcinoma	GDSC	ERKELRRML	DEG_APCC_DBOX_1	0.2222
p.G1156D	ACH-002196	Lung Cancer	CCLE	ERKELRRML	DEG_APCC_DBOX_1	0.2222
p.G1156D	SBC-1	lung	COSMIC	ERKELRRML	DEG_APCC_DBOX_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ERKELRRML

Degron related mutations and impact score

Drug responses associated with TAF1L mutations

All proteins holding degron of ERKELRRML

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZX4	Transcription initiation factor TFIID subunit 1-like	DEG_APCC_DBOX_1	1144:1152	ERKELRRML	APC,CDC20,FZR1	0.6815	More...