DegronMD - Q8IZX4(TAF1L)

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GO - Molecular function (MF): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A191G	TCGA-21-5784	LUSC	TCGA	IAPSFLASEKVDF	DEG_ODPH_VHL_1	190:202	Mutation altering degron motif	0.754
p.A191G	DO27271	LUSC	ICGC	IAPSFLASEKVDF	DEG_ODPH_VHL_1	190:202	Mutation altering degron motif	0.754
p.R1145W	TCGA-22-1012	LUSC	TCGA	ERKELRRML	DEG_APCC_DBOX_1	1144:1152	Mutation altering degron motif	0.8634
p.R1145W	DO233216	GACA	ICGC	ERKELRRML	DEG_APCC_DBOX_1	1144:1152	Mutation altering degron motif	0.8634
p.R1145W	DO27302	LUSC	ICGC	ERKELRRML	DEG_APCC_DBOX_1	1144:1152	Mutation altering degron motif	0.8634
p.Q1135E	TCGA-22-5473	LUSC	TCGA	ERKELRRML	DEG_APCC_DBOX_1	1144:1152	Mutation rewiring degron network	0.0833
p.Q1135E	TCGA-A1-A0SI	BRCA	TCGA	ERKELRRML	DEG_APCC_DBOX_1	1144:1152	Mutation rewiring degron network	0.0833
p.Q1135E	TCGA-UC-A7PF	CESC	TCGA	ERKELRRML	DEG_APCC_DBOX_1	1144:1152	Mutation rewiring degron network	0.0833
p.Q1135E	DO1774	BRCA	ICGC	ERKELRRML	DEG_APCC_DBOX_1	1144:1152	Mutation rewiring degron network	0.0833
p.Q1135E	DO49987	CESC	ICGC	ERKELRRML	DEG_APCC_DBOX_1	1144:1152	Mutation rewiring degron network	0.0833
p.Q1135E	DO26467	LUSC	ICGC	ERKELRRML	DEG_APCC_DBOX_1	1144:1152	Mutation rewiring degron network	0.0833
p.L1148V	TCGA-24-1846	OV	TCGA	ERKELRRML	DEG_APCC_DBOX_1	1144:1152	Mutation altering degron motif	0.6765
p.L1148V	DO32718	OV	ICGC	ERKELRRML	DEG_APCC_DBOX_1	1144:1152	Mutation altering degron motif	0.6765
p.S1157L	TCGA-4E-A92E	UCEC	TCGA	ERKELRRML	DEG_APCC_DBOX_1	1144:1152	Mutation rewiring degron network	0.1944
p.S1157L	DO223277	UCEC	ICGC	ERKELRRML	DEG_APCC_DBOX_1	1144:1152	Mutation rewiring degron network	0.1944
p.V200G	TCGA-55-8204	LUAD	TCGA	IAPSFLASEKVDF	DEG_ODPH_VHL_1	190:202	Mutation altering degron motif	0.7532
p.V200G	DO45322	LUAD	ICGC	IAPSFLASEKVDF	DEG_ODPH_VHL_1	190:202	Mutation altering degron motif	0.7532
p.R1138C	TCGA-AN-A046	BRCA	TCGA	ERKELRRML	DEG_APCC_DBOX_1	1144:1152	Mutation rewiring degron network	0.1667
p.R1138C	DO1285	BRCA	ICGC	ERKELRRML	DEG_APCC_DBOX_1	1144:1152	Mutation rewiring degron network	0.1667
p.L195F	TCGA-BP-5199	KIRC	TCGA	IAPSFLASEKVDF	DEG_ODPH_VHL_1	190:202	Mutation altering degron motif	0.587
p.L195F	DO19813	KIRC	ICGC	IAPSFLASEKVDF	DEG_ODPH_VHL_1	190:202	Mutation altering degron motif	0.587
p.S193F	TCGA-FS-A1ZZ	SKCM	TCGA	IAPSFLASEKVDF	DEG_ODPH_VHL_1	190:202	Mutation altering degron motif	0.6871
p.S193F	DO37412	SKCM	ICGC	IAPSFLASEKVDF	DEG_ODPH_VHL_1	190:202	Mutation altering degron motif	0.6871
p.G1161R	TCGA-HC-A48F	PRAD	TCGA	ERKELRRML	DEG_APCC_DBOX_1	1144:1152	Mutation rewiring degron network	0.0833
p.G1161R	DO46800	PRAD	ICGC	ERKELRRML	DEG_APCC_DBOX_1	1144:1152	Mutation rewiring degron network	0.0833
p.D183Y	TCGA-L9-A444	LUAD	TCGA	IAPSFLASEKVDF	DEG_ODPH_VHL_1	190:202	Mutation rewiring degron network	0.1389
p.D183Y	DO26015	LUAD	ICGC	IAPSFLASEKVDF	DEG_ODPH_VHL_1	190:202	Mutation rewiring degron network	0.1389
p.R1149Q	TCGA-MN-A4N4	LUAD	TCGA	ERKELRRML	DEG_APCC_DBOX_1	1144:1152	Mutation altering degron motif	0.6218
p.R1149Q	DO26250	LUAD	ICGC	ERKELRRML	DEG_APCC_DBOX_1	1144:1152	Mutation altering degron motif	0.6218
p.L1136M	DO222765	COCA	ICGC	ERKELRRML	DEG_APCC_DBOX_1	1144:1152	Mutation rewiring degron network	0.1111
p.S204N	DO234389	ESAD	ICGC	IAPSFLASEKVDF	DEG_ODPH_VHL_1	190:202	Mutation rewiring degron network	0.2778
p.W1140R	DO229512	LAML	ICGC	ERKELRRML	DEG_APCC_DBOX_1	1144:1152	Mutation rewiring degron network	0.2222
p.R1145Q	DO35614	PBCA	ICGC	ERKELRRML	DEG_APCC_DBOX_1	1144:1152	Mutation altering degron motif	0.7329
p.R1149W	DO232761	PBCA	ICGC	ERKELRRML	DEG_APCC_DBOX_1	1144:1152	Mutation altering degron motif	0.7523
p.S203N	SIDM01006	Plasma Cell Myeloma	GDSC	IAPSFLASEKVDF	DEG_ODPH_VHL_1	190:202	Mutation rewiring degron network	0.3056
p.S203N	ACH-000193	Myeloma	CCLE	IAPSFLASEKVDF	DEG_ODPH_VHL_1	190:202	Mutation rewiring degron network	0.3056
p.S203N	KARPAS-620	haematopoietic and lymphoid tissue	COSMIC	IAPSFLASEKVDF	DEG_ODPH_VHL_1	190:202	Mutation rewiring degron network	0.3056
p.P187T	SIDM01156	Small Cell Lung Carcinoma	GDSC	IAPSFLASEKVDF	DEG_ODPH_VHL_1	190:202	Mutation rewiring degron network	0.25
p.P187T	ACH-000890	Lung Cancer	CCLE	IAPSFLASEKVDF	DEG_ODPH_VHL_1	190:202	Mutation rewiring degron network	0.25
p.P187T	SW1271	lung	COSMIC	IAPSFLASEKVDF	DEG_ODPH_VHL_1	190:202	Mutation rewiring degron network	0.25
p.S193Y	SIDM00122	Breast Carcinoma	GDSC	IAPSFLASEKVDF	DEG_ODPH_VHL_1	190:202	Mutation altering degron motif	0.6009
p.S193Y	ACH-000288	Breast Cancer	CCLE	IAPSFLASEKVDF	DEG_ODPH_VHL_1	190:202	Mutation altering degron motif	0.6009
p.S193Y	BT-549	breast	COSMIC	IAPSFLASEKVDF	DEG_ODPH_VHL_1	190:202	Mutation altering degron motif	0.6009
p.R1138S	SIDM00562	Breast Carcinoma	GDSC	ERKELRRML	DEG_APCC_DBOX_1	1144:1152	Mutation rewiring degron network	0.1667
p.R1138S	ACH-002065	Sarcoma	CCLE	ERKELRRML	DEG_APCC_DBOX_1	1144:1152	Mutation rewiring degron network	0.1667
p.R1138S	ACH-002163	Breast Cancer	CCLE	ERKELRRML	DEG_APCC_DBOX_1	1144:1152	Mutation rewiring degron network	0.1667
p.R1138S	MRK-nu-1	breast	COSMIC	ERKELRRML	DEG_APCC_DBOX_1	1144:1152	Mutation rewiring degron network	0.1667
p.G1156D	SIDM00365	Small Cell Lung Carcinoma	GDSC	ERKELRRML	DEG_APCC_DBOX_1	1144:1152	Mutation rewiring degron network	0.2222
p.G1156D	ACH-002196	Lung Cancer	CCLE	ERKELRRML	DEG_APCC_DBOX_1	1144:1152	Mutation rewiring degron network	0.2222
p.G1156D	SBC-1	lung	COSMIC	ERKELRRML	DEG_APCC_DBOX_1	1144:1152	Mutation rewiring degron network	0.2222
p.L186F	ACH-000695	Lung Cancer	CCLE	IAPSFLASEKVDF	DEG_ODPH_VHL_1	190:202	Mutation rewiring degron network	0.2222
p.I189V	ACH-000923	Lymphoma	CCLE	IAPSFLASEKVDF	DEG_ODPH_VHL_1	190:202	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TAF1L

UniProt ID: Q8IZX4

Entrez ID: 138474

Protein name: Transcription initiation factor TFIID subunit 1-like (TAF(II)210) (TBP-associated factor 1-like) (TBP-associated factor 210 kDa) (Transcription initiation factor TFIID 210 kDa subunit)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TAF1L in