DegronMD

Uniprot ID: Q8IZX4

Source protein: Transcription initiation factor TFIID subunit 1-like

Source gene: TAF1L

Class: DEG_ODPH_VHL_1

Location: 190:202

E3 ligase: VHL

DEGRON score: 0.7098

ASA_SCORE: 76.9615

COIL: 0.7015

CONS_SCORE: 0.2368

DSS_SCORE: 0.3547

HELIX: 0.252

FCONS_SCORE: 0.9554

RIG_SCORE: 0.7677

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A191G	TCGA-21-5784	LUSC	TCGA	IAPSFLASEKVDF	DEG_ODPH_VHL_1	0.754
p.A191G	DO27271	LUSC	ICGC	IAPSFLASEKVDF	DEG_ODPH_VHL_1	0.754
p.V200G	TCGA-55-8204	LUAD	TCGA	IAPSFLASEKVDF	DEG_ODPH_VHL_1	0.7532
p.V200G	DO45322	LUAD	ICGC	IAPSFLASEKVDF	DEG_ODPH_VHL_1	0.7532
p.L195F	TCGA-BP-5199	KIRC	TCGA	IAPSFLASEKVDF	DEG_ODPH_VHL_1	0.587
p.L195F	DO19813	KIRC	ICGC	IAPSFLASEKVDF	DEG_ODPH_VHL_1	0.587
p.S193F	TCGA-FS-A1ZZ	SKCM	TCGA	IAPSFLASEKVDF	DEG_ODPH_VHL_1	0.6871
p.S193F	DO37412	SKCM	ICGC	IAPSFLASEKVDF	DEG_ODPH_VHL_1	0.6871
p.D183Y	TCGA-L9-A444	LUAD	TCGA	IAPSFLASEKVDF	DEG_ODPH_VHL_1	0.1389
p.D183Y	DO26015	LUAD	ICGC	IAPSFLASEKVDF	DEG_ODPH_VHL_1	0.1389
p.S204N	DO234389	ESAD	ICGC	IAPSFLASEKVDF	DEG_ODPH_VHL_1	0.2778
p.S203N	SIDM01006	Plasma Cell Myeloma	GDSC	IAPSFLASEKVDF	DEG_ODPH_VHL_1	0.3056
p.S203N	ACH-000193	Myeloma	CCLE	IAPSFLASEKVDF	DEG_ODPH_VHL_1	0.3056
p.S203N	KARPAS-620	haematopoietic_and_lymphoid_tissue	COSMIC	IAPSFLASEKVDF	DEG_ODPH_VHL_1	0.3056
p.P187T	SIDM01156	Small Cell Lung Carcinoma	GDSC	IAPSFLASEKVDF	DEG_ODPH_VHL_1	0.25
p.P187T	ACH-000890	Lung Cancer	CCLE	IAPSFLASEKVDF	DEG_ODPH_VHL_1	0.25
p.P187T	SW1271	lung	COSMIC	IAPSFLASEKVDF	DEG_ODPH_VHL_1	0.25
p.S193Y	SIDM00122	Breast Carcinoma	GDSC	IAPSFLASEKVDF	DEG_ODPH_VHL_1	0.6009
p.S193Y	ACH-000288	Breast Cancer	CCLE	IAPSFLASEKVDF	DEG_ODPH_VHL_1	0.6009
p.S193Y	BT-549	breast	COSMIC	IAPSFLASEKVDF	DEG_ODPH_VHL_1	0.6009
p.L186F	ACH-000695	Lung Cancer	CCLE	IAPSFLASEKVDF	DEG_ODPH_VHL_1	0.2222
p.I189V	ACH-000923	Lymphoma	CCLE	IAPSFLASEKVDF	DEG_ODPH_VHL_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZX4	Transcription initiation factor TFIID subunit 1-like	DEG_ODPH_VHL_1	190:202	IAPSFLASEKVDF	VHL	0.7098	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons