DegronMD

Uniprot ID: O94989

Source protein: Rho guanine nucleotide exchange factor 15

Source gene: ARHGEF15

Class: DEG_APCC_DBOX_1

Location: 271:279

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9387

ASA_SCORE: 110.7

COIL: 0.6747

CONS_SCORE: 0.4835

DSS_SCORE: 0.5601

HELIX: 0.3187

FCONS_SCORE: 1.1102

RIG_SCORE: 0.7527

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R272C	TCGA-06-5416	GBM	TCGA	ERKLLPLLK	DEG_APCC_DBOX_1	0.8301
p.R272C	DO10880	GBM	ICGC	ERKLLPLLK	DEG_APCC_DBOX_1	0.8301
p.R267H	TCGA-AA-A00N	COAD	TCGA	ERKLLPLLK	DEG_APCC_DBOX_1	0.2222
p.R267H	DO9876	COAD	ICGC	ERKLLPLLK	DEG_APCC_DBOX_1	0.2222
p.R272H	TCGA-E6-A1LX	UCEC	TCGA	ERKLLPLLK	DEG_APCC_DBOX_1	0.8244
p.R272H	DO222884	COCA	ICGC	ERKLLPLLK	DEG_APCC_DBOX_1	0.8244
p.R272H	DO41020	UCEC	ICGC	ERKLLPLLK	DEG_APCC_DBOX_1	0.8244
p.R285C	TCGA-VS-A8EC	CESC	TCGA	ERKLLPLLK	DEG_APCC_DBOX_1	0.1667
p.R285C	DO51618	CESC	ICGC	ERKLLPLLK	DEG_APCC_DBOX_1	0.1667
p.L277P	DO227999	COCA	ICGC	ERKLLPLLK	DEG_APCC_DBOX_1	0.6471
p.L277P	DO229010	COCA	ICGC	ERKLLPLLK	DEG_APCC_DBOX_1	0.6471
p.L277P	DO229013	COCA	ICGC	ERKLLPLLK	DEG_APCC_DBOX_1	0.6471
p.L277P	DO229016	COCA	ICGC	ERKLLPLLK	DEG_APCC_DBOX_1	0.6471
p.L277P	DO229003	COCA	ICGC	ERKLLPLLK	DEG_APCC_DBOX_1	0.6471
p.L277P	DO229005	COCA	ICGC	ERKLLPLLK	DEG_APCC_DBOX_1	0.6471
p.L277P	DO229473	LAML	ICGC	ERKLLPLLK	DEG_APCC_DBOX_1	0.6471
p.R285H	DO50447	ESAD	ICGC	ERKLLPLLK	DEG_APCC_DBOX_1	0.1667
p.V261I	DO45299	LIRI	ICGC	ERKLLPLLK	DEG_APCC_DBOX_1	0.0556
p.P281S	DO222875	MELA	ICGC	ERKLLPLLK	DEG_APCC_DBOX_1	0.2778
p.L274P	DO219881	SKCA	ICGC	ERKLLPLLK	DEG_APCC_DBOX_1	0.6471
p.L274P	DO218904	SKCA	ICGC	ERKLLPLLK	DEG_APCC_DBOX_1	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94989	Rho guanine nucleotide exchange factor 15	DEG_APCC_DBOX_1	271:279	ERKLLPLLK	APC,CDC20,FZR1	0.9387	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons